Understanding working memory: from cells to brain stimulation

了解工作记忆：从细胞到大脑刺激

• 批准号: FT210100694
• 负责人: Dr Nigel Rogasch
• 金额: $ 68.75万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-01-04 至 2026-07-26
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT210100694
• 关键词: Understanding; working; memory; cells; brain

This project aims to understand the neural mechanisms of working memory, a fundamental cognitive function in humans, using a novel framework which combines non-invasive brain stimulation, neuroimaging, pharmacological and experimental manipulations, and biological modelling. Expected outcomes include a critical understanding of the cellular mechanisms underlying both neural activity and working memory ability in healthy individuals and a detailed knowledge of how to non-invasively interact with these mechanisms using brain stimulation. This will provide significant benefits such as the development of individually optimised brain stimulation protocols, enabling tailored approaches to reliably alter brain function and cognition.

本项目旨在了解工作记忆的神经机制，这是人类基本的认知功能，采用一种结合非侵入性脑刺激、神经成像、药理和实验操作以及生物建模的新框架。预期的结果包括对健康个体神经活动和工作记忆能力背后的细胞机制的批判性理解，以及如何使用脑刺激与这些机制非侵入性相互作用的详细知识。这将提供显著的好处，如开发单独优化的脑刺激方案，使量身定制的方法能够可靠地改变大脑功能和认知。