How inhibition shapes human brain oscillations and working memory capacity

抑制如何塑造人脑振荡和工作记忆能力

• 批准号: DP170100738
• 负责人: Dr Nigel Rogasch
• 金额: $ 27.47万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-09 至 2021-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP170100738
• 关键词: How; inhibition; shapes; human; brain

This project aims to investigate the link between inhibitory mechanisms, gamma oscillations and working memory in humans. Retaining information in short-term ‘working’ memory is crucial for cognition, influencing our personality and intelligence. However, the brain mechanisms underlying this process are unclear. Evidence from animal/computational research indicates that brain oscillations in high frequency ‘gamma’ bands, which depend on neural inhibition, are critical for working memory. Mapping a path from molecules to cognition will detail how neural mechanisms shape human behavioural performance and guide efforts to enhance memory and cognitive function.

该项目旨在研究人类的抑制机制、伽马振荡和工作记忆之间的联系。在短期“工作”记忆中保留信息对认知至关重要，影响我们的个性和智力。然而，这一过程背后的大脑机制尚不清楚。来自动物/计算研究的证据表明，依赖于神经抑制的高频“伽马”波段的脑振荡对工作记忆至关重要。绘制从分子到认知的路径将详细说明神经机制如何塑造人类行为表现，并指导增强记忆和认知功能的努力。