HORMONE RHYTHMS--METABOLIC SIGNIFICANCE IN PSYCHIATRY

激素节律——精神病学中的代谢意义

• 批准号: 3076127
• 负责人: Robert T. Rubin
• 金额: $ 10.69万
• 依托单位: LOS ANGELES COUNTY HARBOR-UCLA MED CTR
• 依托单位国家: 美国
• 财政年份: 1982
• 资助国家: 美国
• 起止时间: 1982-07-02 至 1992-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3076127
• 关键词: REM sleep; adrenocorticotropic hormone; antiadrenergic agents; anticholinergic agent; blood chemistry; circadian rhythms; clinical depression; cortisol; electroencephalography; electrophysiology; hormone regulation /control mechanism; human subject; laboratory rabbit; luteinizing hormone; melatonin; neural information processing; neuroendocrine system; neurotransmitters; peptide hormone metabolism; psychobiology; psychopharmacology; radioimmunoassay; saliva; sex hormones; sleep; steroid hormone metabolism; thyrotropin; thyrotropin releasing hormone; urinalysis

This is a request for a continuation of my ADAMHA Research Scientist Award. Receiving this continuation will permit me to further my research programs in psychoneuroendocrinology, which have grown and developed over the past 20 years. My studies focus on the neuroendocrinology of depressive disorders, with particular reference to (1) assessing the utility of endocrine testing and sleep electrophysiology as aids in the diagnosis of endogenous depression and (2) determining the underlying mechanisms of neuroendocrine disturbances in depression. There are several objectives for the next five years. The first is to finish the data analyses and reports of our major study of a long- form neuroendocrine protocol (nocturnal blood sampling, TRH and LHRH stimulation tests, dexamethasone suppression test (DST) conducted on 40 definite endogenous depressed patients and 40 matched normal control subjects. Additional hormones planned for analysis include metabolically free serum fractions of steroid hormones and melatonin. Based on this work, we have developed a new, sensitive, and specific short-form sleep-endocrine protocol, which combines sleep electrophysiology, a 0.5 mg 8-hr DST, and a TRH stimulation test. The second objective of this research is to validate the clinical utility of this protocol by applying it to several diagnostic categories of depressed patients, including endogenous and nonendogenous depressives, dysthymics, and other comparison groups. A third objective is to continue my collaboration with Dr. Russell Poland for the study of more fundamental neuroendocrine aspects of depression, including the relationship of bioactive to immunoactive ACTH secretion. Finally, I plan to continue gaining experience with a new experimental paradigm, the use of fetal neuron transplants to introduce neurotransmitters into different areas of the brain involved in neuroendocrine regulation, to attempt to elucidate the roles in neuroendocrine function of different neurotransmitters at specific neuroanatomical sites.

这是一个请求继续我的阿达姆哈研究 科学家奖。 收到这份续篇将允许我 进一步推动我在心理神经内分泌学方面的研究计划， 在过去的20年里成长和发展。 我的学业 专注于抑郁症的神经内分泌学， 特别提到（1）评估内分泌的效用 测试和睡眠电生理学作为诊断的辅助手段 内源性抑郁症和（2）确定潜在的 抑郁症的神经内分泌紊乱机制。 那里 是未来五年的几个目标。 一是 完成我们长期以来的主要研究的数据分析和报告， 形成神经内分泌方案（夜间采血，TRH和 LHRH刺激试验，地塞米松抑制试验（DST） 对40例确定的内源性抑郁症患者和40例 匹配的正常对照组。 计划增加激素 包括类固醇的代谢游离血清级分 荷尔蒙和褪黑素 基于这项工作，我们开发了一种新的，敏感的， 具体的短期睡眠内分泌协议，它结合了 睡眠电生理学、0.5 mg 8小时DST和TRH 刺激试验 本研究的第二个目的是 通过将本方案应用于 抑郁症患者的几种诊断类别，包括 内源性和非内源性抑郁症、精神障碍和其他 比较组。 第三个目标是继续与罗素博士合作 波兰，研究更基本的神经内分泌方面 抑郁症，包括生物活性与 免疫活性ACTH分泌。 最后，我计划继续获得 经验与一个新的实验范式，使用胎儿 神经元移植将神经递质引入不同的 参与神经内分泌调节的大脑区域， 试图阐明神经内分泌功能的作用， 不同的神经递质在特定的神经解剖部位。