HORMONE RHYTHMS--METABOLIC SIGNIFICANCE IN PSYCHIATRY

这是继续我的ADAMHA研究的请求 科学家奖。收到这份续集将使我能够 进一步我在心理神经内分泌学方面的研究计划 在过去的20年里成长和发展。我的学习 关注抑郁症的神经内分泌学，与 特别参考(1)评估内分泌的效用 检测和睡眠电生理学有助于诊断 内源性抑郁和(2)确定潜在的 抑郁症神经内分泌紊乱的机制。那里 是未来五年的几个目标。第一个是 完成了我们长期的重大研究的数据分析和报告- 形成神经内分泌方案(夜间采血、TRH和 LHRH刺激试验、地塞米松抑制试验(DST) 对40例确诊内源性抑郁症患者和40例内源性抑郁症患者进行调查 匹配的正常对照组受试者。计划增加荷尔蒙 用于分析包括代谢自由的类固醇血清部分 荷尔蒙和褪黑素。 在这项工作的基础上，我们开发了一种新的、敏感的和 特定的短时睡眠-内分泌方案，它结合了 睡眠电生理学，0.5毫克8小时DST和TRH 刺激试验。这项研究的第二个目标是 通过将该方案应用于 抑郁症患者的几种诊断类别，包括 内源性和非内源性抑郁症、心境恶劣和其他 比较组。 第三个目标是继续我与罗素博士的合作 波兰对更基本的神经内分泌方面的研究 包括生物活性与抑郁症的关系 免疫活性ACTH分泌。最后，我计划继续获得 体验一种新的实验范式，使用胎儿 神经元移植将神经递质引入不同的 参与神经内分泌调节的大脑区域，以 试图阐明其在神经内分泌功能中的作用 特定神经解剖部位的不同神经递质。

This is a request for a continuation of my ADAMHA Research Scientist Award. Receiving this continuation will permit me to further my research programs in psychoneuroendocrinology, which have grown and developed over the past 20 years. My studies focus on the neuroendocrinology of depressive disorders, with particular reference to (1) assessing the utility of endocrine testing and sleep electrophysiology as aids in the diagnosis of endogenous depression and (2) determining the underlying mechanisms of neuroendocrine disturbances in depression. There are several objectives for the next five years. The first is to finish the data analyses and reports of our major study of a long- form neuroendocrine protocol (nocturnal blood sampling, TRH and LHRH stimulation tests, dexamethasone suppression test (DST) conducted on 40 definite endogenous depressed patients and 40 matched normal control subjects. Additional hormones planned for analysis include metabolically free serum fractions of steroid hormones and melatonin. Based on this work, we have developed a new, sensitive, and specific short-form sleep-endocrine protocol, which combines sleep electrophysiology, a 0.5 mg 8-hr DST, and a TRH stimulation test. The second objective of this research is to validate the clinical utility of this protocol by applying it to several diagnostic categories of depressed patients, including endogenous and nonendogenous depressives, dysthymics, and other comparison groups. A third objective is to continue my collaboration with Dr. Russell Poland for the study of more fundamental neuroendocrine aspects of depression, including the relationship of bioactive to immunoactive ACTH secretion. Finally, I plan to continue gaining experience with a new experimental paradigm, the use of fetal neuron transplants to introduce neurotransmitters into different areas of the brain involved in neuroendocrine regulation, to attempt to elucidate the roles in neuroendocrine function of different neurotransmitters at specific neuroanatomical sites.