BRAIN CONTROL\GASTRIC SECRETION & STRESS-INDUCED LESIONS
BRAIN CONTROL\GASTRIC SECRETION & STRESS-INDUCED LESIONS
批准号:
3075837
负责人:
YVETTE FRANCE TACHE
金额:
$6.13万
依托单位国家:
美国
项目类别:
财政年份:
1988
资助国家:
美国
项目状态:
已结题
起止时间:
1988-07-01 至 1993-06-30
关键词:
autonomic nervous system bombesin brain mapping central nervous system central neural pathway /tract corticotropin releasing factor dorsal motor nucleus gastric juice gastrointestinal circulation histamine laboratory rat microinjections neuroendocrine system neuropeptides peptic ulcer serotonin spinal cord mapping stomach stomach emptying stomach motility /pressure stress thyrotropin releasing hormone
中文摘要
以前,我们获得的证据表明,特定的神经肽,
例如蛙皮素样肽,促甲状腺素释放因子,
促肾上腺皮质激素释放因子、生长抑素、阿片肽和
降钙素基因相关肽,作用于大脑,
胃分泌、收缩性和排空以及致溃疡性
对压力的反应。 这些调查结果和其他报告
研究者们描绘了一个与大脑有关的新概念
胃功能的肽能调节。
该研究计划的目标将是进一步发展
这样的调查领域,以达到更好地了解
胃分泌和运动功能的脑调节。 的
具体目标将是:1)定位大脑活动部位,
蛙皮素、TRH和CRF对胃功能和应激的影响
在特定脑中使用肽的微量注射的溃疡形成
含有神经终末纤维和/或受体的核,
这些肽2)阐明神经体液途径
将信息从大脑传递到胃部,
外科、药理学和电生理学技术,3)
为了使用选择性的方法评估这些肽的生理作用,
拮抗剂和被动免疫。
这些研究将产生关于大脑结构的重要信息,
参与大脑调节的神经通路和神经递质
胃功能,并有相关的影响,
了解应激性溃疡的发病机制与饮食
与胃排空改变有关的疾病。
英文摘要
Previously, we obtained evidence that specific neuropeptides,
such as bombesin-like peptides, thyrotropin-releasing factor,
corticotropin-releasing factor, somatostatin, opioid peptides and
calcitonin gene-related peptide, act within the brain to influence
gastric secretion, contractility and emptying and the ulcerogenic
response to stress. These findings and reports by other
investigators have delineated a new concept related to brain
peptidergic regulation of gastric function.
The objectives of the research program will be to develop further
such field of investigation to reach a better understanding of
brain regulation of gastric secretory and motor function. The
specific aims will be 1) to localize brain sites of action of
bombesin, TRH, and CRF to influence gastric function and stress
ulceration using microinjection of peptides in specific brain
nucleus containing nerve terminal fibers and/or receptors for
these peptides 2) to elucidate the neurohumoral pathways
mediating the information from brain sites to the stomach using
surgical, pharmacological and electrophysiological techniques, 3)
to assess the physiologic role of these peptides using selective
antagonists and passive immunization.
Such studies will yield important information on brain structures,
pathways and neurotransmitters involved in brain regulation of
gastric function and have relevant implications in the
understanding of the pathogenesis of stress ulcer and eating
disorders associated with alteration of gastric emptying.
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专著(0)
科研奖励(0)
会议论文
Mechanisms and therapeutic interventions of postoperative gastric ileus
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批准号:10383642
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项目类别:
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资助金额:$0.0万
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财政年份:2017
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负责人:YVETTE FRANCE TACHE
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依托单位:
Comprehensive Structural and Functional Mapping of Mammalian Colonic Nervous System
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批准号:9776992
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项目类别:
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资助金额:$247.51万
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财政年份:2017
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负责人:YVETTE FRANCE TACHE
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依托单位:
Comprehensive Structural and Functional Mapping of Mammalian Colonic Nervous System
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批准号:10008153
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项目类别:
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资助金额:$262.71万
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财政年份:2017
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负责人:YVETTE FRANCE TACHE
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依托单位:
Mechanisms of Postoperative Ileus
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批准号:7688268
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项目类别:
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资助金额:$0.0万
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财政年份:2009
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负责人:YVETTE FRANCE TACHE
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依托单位:
Mechanisms of Postoperative Ileus
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批准号:8195940
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项目类别:
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资助金额:$0.0万
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财政年份:2009
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负责人:YVETTE FRANCE TACHE
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依托单位:
Mechanisms of Postoperative Ileus
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批准号:8258634
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项目类别:
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资助金额:$0.0万
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财政年份:2009
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负责人:YVETTE FRANCE TACHE
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依托单位:
Mechanisms of Postoperative Ileus
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批准号:7784483
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项目类别:
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资助金额:$0.0万
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财政年份:2009
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负责人:YVETTE FRANCE TACHE
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依托单位:
Stress-Induced Activition of Colonic Motor Function
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批准号:7898181
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项目类别:
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资助金额:$2.72万
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财政年份:2009
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负责人:YVETTE FRANCE TACHE
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依托单位:
C0RE--ANIMAL MODELS
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批准号:7415061
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项目类别:
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资助金额:$7.45万
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财政年份:2006
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负责人:YVETTE FRANCE TACHE
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依托单位:
CORE--ANIMAL MODELS
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批准号:6825451
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项目类别:
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资助金额:$7.67万
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财政年份:2004
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负责人:YVETTE FRANCE TACHE
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依托单位:
CORE--ANIMAL MODELS
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批准号:6564256
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项目类别:
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资助金额:$14.67万
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财政年份:2001
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负责人:YVETTE FRANCE TACHE
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依托单位:
STRESS-INDUCED ACTIVATION OF COLONIC MOTOR FUNCTION
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批准号:6524591
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项目类别:
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资助金额:$18.52万
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财政年份:2000
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负责人:YVETTE FRANCE TACHE
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依托单位:
STRESS-INDUCED ACTIVATION OF COLONIC MOTOR FUNCTION
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批准号:6615688
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项目类别:
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资助金额:$18.52万
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财政年份:2000
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负责人:YVETTE FRANCE TACHE
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依托单位:
Stress-Induced Activation of Colonic Motor Function
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批准号:8577075
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项目类别:
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资助金额:$25.2万
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财政年份:2000
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负责人:YVETTE FRANCE TACHE
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依托单位:
Stress-Induced Activition of Colonic Motor Function
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批准号:7903389
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项目类别:
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资助金额:$24.33万
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财政年份:2000
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负责人:YVETTE FRANCE TACHE
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依托单位:
STRESS-INDUCED ACTIVATION OF COLONIC MOTOR FUNCTION
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项目类别:
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资助金额:$12.42万
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财政年份:2000
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负责人:YVETTE FRANCE TACHE
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依托单位:
STRESS-INDUCED ACTIVATION OF COLONIC MOTOR FUNCTION
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批准号:6381745
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项目类别:
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资助金额:$18.52万
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财政年份:2000
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负责人:YVETTE FRANCE TACHE
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依托单位:
STRESS-INDUCED ACTIVATION OF COLONIC MOTOR FUNCTION
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批准号:6493208
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项目类别:
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资助金额:$11.12万
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财政年份:2000
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负责人:YVETTE FRANCE TACHE
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依托单位:
STRESS-INDUCED ACTIVATION OF COLONIC MOTOR FUNCTION
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批准号:6792008
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项目类别:
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资助金额:$18.52万
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财政年份:2000
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负责人:YVETTE FRANCE TACHE
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依托单位:
STRESS-INDUCED ACTIVATION OF COLONIC MOTOR FUNCTION
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批准号:6197002
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项目类别:
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资助金额:$18.42万
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财政年份:2000
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负责人:YVETTE FRANCE TACHE
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依托单位:
国内基金
海外基金
Bombesin修饰的纳米粒肿瘤靶向性及靶向递药效果研究
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批准号:81603018
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项目类别:青年科学基金项目
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资助金额:17.3万元
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批准年份:2016
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负责人:刘珊
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依托单位:
Bombesin导向的肿瘤细胞选择性促凋亡分子优化设计及PEG定点修饰
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批准号:81072566
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批准年份:2010
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负责人:卢晓风
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依托单位: