课题基金 / 基金详情

BRAIN CONTROL\GASTRIC SECRETION & STRESS-INDUCED LESIONS

BRAIN CONTROL\GASTRIC SECRETION & STRESS-INDUCED LESIONS
大脑控制胃分泌
批准号:
3075837
负责人:
YVETTE FRANCE TACHE
金额:
$6.13万
依托单位国家:
美国
项目类别:
财政年份:
1988
资助国家:
美国
项目状态:
已结题
起止时间:
1988-07-01 至 1993-06-30

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项目成果

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中文摘要
翻译
之前,我们获得了特定神经肽的证据,
英文摘要
Previously, we obtained evidence that specific neuropeptides, such as bombesin-like peptides, thyrotropin-releasing factor, corticotropin-releasing factor, somatostatin, opioid peptides and calcitonin gene-related peptide, act within the brain to influence gastric secretion, contractility and emptying and the ulcerogenic response to stress. These findings and reports by other investigators have delineated a new concept related to brain peptidergic regulation of gastric function. The objectives of the research program will be to develop further such field of investigation to reach a better understanding of brain regulation of gastric secretory and motor function. The specific aims will be 1) to localize brain sites of action of bombesin, TRH, and CRF to influence gastric function and stress ulceration using microinjection of peptides in specific brain nucleus containing nerve terminal fibers and/or receptors for these peptides 2) to elucidate the neurohumoral pathways mediating the information from brain sites to the stomach using surgical, pharmacological and electrophysiological techniques, 3) to assess the physiologic role of these peptides using selective antagonists and passive immunization. Such studies will yield important information on brain structures, pathways and neurotransmitters involved in brain regulation of gastric function and have relevant implications in the understanding of the pathogenesis of stress ulcer and eating disorders associated with alteration of gastric emptying.
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会议论文
Mechanisms and therapeutic interventions of postoperative gastric ileus
Comprehensive Structural and Functional Mapping of Mammalian Colonic Nervous System
Comprehensive Structural and Functional Mapping of Mammalian Colonic Nervous System
Mechanisms of Postoperative Ileus
国内基金
海外基金
Bombesin修饰的纳米粒肿瘤靶向性及靶向递药效果研究
  • 批准号:
    81603018
  • 项目类别:
    青年科学基金项目
  • 资助金额:
    17.3万元
  • 批准年份:
    2016
  • 负责人:
    刘珊
  • 依托单位:
Bombesin导向的肿瘤细胞选择性促凋亡分子优化设计及PEG定点修饰
  • 批准号:
    81072566
  • 项目类别:
    面上项目
  • 资助金额:
    36.0万元
  • 批准年份:
    2010
  • 负责人:
    卢晓风
  • 依托单位: