BRAIN CONTROL\GASTRIC SECRETION & STRESS-INDUCED LESIONS

以前，我们获得的证据表明，特定的神经肽， 例如蛙皮素样肽，促甲状腺素释放因子， 促肾上腺皮质激素释放因子、生长抑素、阿片肽和 降钙素基因相关肽，作用于大脑， 胃分泌、收缩性和排空以及致溃疡性 对压力的反应。 这些调查结果和其他报告 研究者们描绘了一个与大脑有关的新概念 胃功能的肽能调节。 该研究计划的目标将是进一步发展 这样的调查领域，以达到更好地了解 胃分泌和运动功能的脑调节。 的 具体目标将是：1）定位大脑活动部位， 蛙皮素、TRH和CRF对胃功能和应激的影响 在特定脑中使用肽的微量注射的溃疡形成 含有神经终末纤维和/或受体的核， 这些肽2）阐明神经体液途径 将信息从大脑传递到胃部， 外科、药理学和电生理学技术，3） 为了使用选择性的方法评估这些肽的生理作用， 拮抗剂和被动免疫。 这些研究将产生关于大脑结构的重要信息， 参与大脑调节的神经通路和神经递质 胃功能，并有相关的影响， 了解应激性溃疡的发病机制与饮食 与胃排空改变有关的疾病。

Previously, we obtained evidence that specific neuropeptides, such as bombesin-like peptides, thyrotropin-releasing factor, corticotropin-releasing factor, somatostatin, opioid peptides and calcitonin gene-related peptide, act within the brain to influence gastric secretion, contractility and emptying and the ulcerogenic response to stress. These findings and reports by other investigators have delineated a new concept related to brain peptidergic regulation of gastric function. The objectives of the research program will be to develop further such field of investigation to reach a better understanding of brain regulation of gastric secretory and motor function. The specific aims will be 1) to localize brain sites of action of bombesin, TRH, and CRF to influence gastric function and stress ulceration using microinjection of peptides in specific brain nucleus containing nerve terminal fibers and/or receptors for these peptides 2) to elucidate the neurohumoral pathways mediating the information from brain sites to the stomach using surgical, pharmacological and electrophysiological techniques, 3) to assess the physiologic role of these peptides using selective antagonists and passive immunization. Such studies will yield important information on brain structures, pathways and neurotransmitters involved in brain regulation of gastric function and have relevant implications in the understanding of the pathogenesis of stress ulcer and eating disorders associated with alteration of gastric emptying.