课题基金 / 基金详情

DIAPHRAGM ADAPTATIONS TO RESPIRATORY TRAINING

DIAPHRAGM ADAPTATIONS TO RESPIRATORY TRAINING
隔膜对呼吸训练的适应
批准号:
3082550
负责人:
DAVID J PREZANT
金额:
$7.77万
依托单位国家:
美国
项目类别:
财政年份:
1988
资助国家:
美国
项目状态:
已结题
起止时间:
1988-09-01 至 1993-08-31

项目摘要

项目成果

DAVID J PREZANT的其他基金

相似基金

相关文献

中文摘要
翻译
呼吸肌疲劳和机械呼吸机依赖
英文摘要
Respiratory muscle fatigue and mechanical ventilator dependency contribute significantly to the morbidity and mortality of patients suffereing from chronic pulmonary disease. The diaphragm is the principal muscle of inspiration and the only skeletal muscle considered to be a vital organ. Yet, the adaptive capability of the diaphragm to varying amounts of respiratory work has received little investigative attention. The aim of this project will be to define the biochemical characteristics and mechanisms by which the rat diaphragm adapts to overuse and disuse; to determine if the adaptation to disuse is preventable or reversible and to gain new insight into the biochemical limitations responsible for respiratory muscle fatigue and failure. This will be accomplished employing experimental models already in use by this applicant. Specifically, surgically implanted tracheal resistors are used to study the diaphragm's response to endurance training and prolonged mechanical ventilation is used to study the diaphragm's response to disuse. The adaptive response of the diaphragm will be analyzed using measurements of fiber type, contractility and endurance as well as functional biochemical indices of whole muscle and mitochondria oxidative capacity, Preliminary data indicates that rat diaphragm muscle does adapt to resistance training with hypertrophy and adapts to mechanical ventilation with atrophy.
期刊论文(10)
专著(0)
科研奖励(0)
会议论文
Gender-specific effects of dexamethasone treatment on rat diaphragm structure and function.
地塞米松治疗对大鼠膈肌结构和功能的性别特异性影响。
DOI: 10.1152/jappl.1997.82.1.125
发表时间: 1997
期刊: Journal of applied physiology (Bethesda, Md. : 1985)
影响因子: --
作者: [Prezant,DJ, Karwa,ML, Richner,B, Maggiore,D, Gentry,EI, Cahill,J]
通讯作者: Cahill,J
Short- and long-term effects of testosterone on diaphragm in castrated and normal male rats.
睾酮对去势雄性大鼠和正常雄性大鼠膈肌的短期和长期影响。
DOI: 10.1152/jappl.1997.82.1.134
发表时间: 1997
期刊: Journal of applied physiology (Bethesda, Md. : 1985)
影响因子: --
作者: [Prezant,DJ, Karwa,ML, Kim,HH, Maggiore,D, Chung,V, Valentine,DE]
通讯作者: Valentine,DE
Effects of short-term and long-term androgen treatment on the diaphragm in male and female rats.
短期和长期雄激素治疗对雄性和雌性大鼠膈肌的影响。
DOI: 10.1152/jappl.1993.75.3.1140
发表时间: 1993
期刊: Journal of applied physiology (Bethesda, Md. : 1985)
影响因子: --
作者: [Prezant,DJ, Valentine,DE, Gentry,EI, Richner,B, Cahill,J, Freeman,K]
通讯作者: Freeman,K
Effect of long-term undernutrition on male and female rat diaphragm contractility, fatigue, and fiber types.
长期营养不良对雄性和雌性大鼠膈肌收缩力、疲劳和纤维类型的影响。
DOI: 10.1152/jappl.1994.76.4.1540
发表时间: 1994
期刊: Journal of applied physiology (Bethesda, Md. : 1985)
影响因子: --
作者: [Prezant,DJ, Richner,B, Aldrich,TK, Valentine,DE, Gentry,EI, Cahill,J]
通讯作者: Cahill,J
7
    EARLY DETECTION OF CLONAL HEMATOPOIESIS AND LEUKEMIA ASSOCIATED MUTATIONS IN WTC EXPOSED FIREFIGHTERS AFTER THE 9/11 ATTACKS
    EARLY DETECTION OF CLONAL HEMATOPOIESIS AND LEUKEMIA ASSOCIATED MUTATIONS IN WTC EXPOSED FIREFIGHTERS AFTER THE 9/11 ATTACKS
    EARLY DETECTION OF CLONAL HEMATOPOIESIS AND LEUKEMIA ASSOCIATED MUTATIONS IN WTC EXPOSED FIREFIGHTERS AFTER THE 9/11 ATTACKS
    NYC Fire Dept. Data Coordinating Ctr for WTC Medicals
    • 批准号:
      6900218
    • 项目类别:
    • 资助金额:
      $113.39万
    • 财政年份:
      2004
    • 负责人:
      DAVID J PREZANT
    • 依托单位:
    海外基金