DIAPHRAGM ADAPTATIONS TO RESPIRATORY TRAINING
DIAPHRAGM ADAPTATIONS TO RESPIRATORY TRAINING
批准号:
3082550
负责人:
DAVID J PREZANT
金额:
$7.77万
依托单位国家:
美国
项目类别:
财政年份:
1988
资助国家:
美国
项目状态:
已结题
起止时间:
1988-09-01 至 1993-08-31
中文摘要
呼吸肌疲劳与机械呼吸机依赖
极大地增加了患者的发病率和死亡率
患有慢性肺部疾病。横隔膜是指
主要的吸气肌和唯一的骨骼肌
被认为是重要的器官。然而,网络的适应能力
隔膜到不同量的呼吸功已收到
很少有调查关注。该项目的目标将是
定义生物化学特征和生物化学机制
大鼠横隔膜适应过度使用和停用;以确定
对废用的适应是可以预防或可逆的,并可获得
对生物化学局限性的新见解
呼吸肌疲劳和衰竭。这将会实现的
采用本申请者已在使用的实验模型。
具体地说,手术植入的气管电阻器被用来
研究横隔膜对耐力训练的反应
采用长时间机械通气法研究横隔膜
对废弃的反应。隔膜的自适应响应将
通过测量纤维类型、伸缩性和
耐力与整体机能生化指标
肌肉和线粒体氧化能力,初步数据
表明大鼠横隔肌确实适应了阻力
肥大训练适应机械通气
伴有萎缩。
英文摘要
Respiratory muscle fatigue and mechanical ventilator dependency
contribute significantly to the morbidity and mortality of patients
suffereing from chronic pulmonary disease. The diaphragm is the
principal muscle of inspiration and the only skeletal muscle
considered to be a vital organ. Yet, the adaptive capability of the
diaphragm to varying amounts of respiratory work has received
little investigative attention. The aim of this project will be to
define the biochemical characteristics and mechanisms by which
the rat diaphragm adapts to overuse and disuse; to determine if
the adaptation to disuse is preventable or reversible and to gain
new insight into the biochemical limitations responsible for
respiratory muscle fatigue and failure. This will be accomplished
employing experimental models already in use by this applicant.
Specifically, surgically implanted tracheal resistors are used to
study the diaphragm's response to endurance training and
prolonged mechanical ventilation is used to study the diaphragm's
response to disuse. The adaptive response of the diaphragm will
be analyzed using measurements of fiber type, contractility and
endurance as well as functional biochemical indices of whole
muscle and mitochondria oxidative capacity, Preliminary data
indicates that rat diaphragm muscle does adapt to resistance
training with hypertrophy and adapts to mechanical ventilation
with atrophy.
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Gender-specific effects of dexamethasone treatment on rat diaphragm structure and function.
地塞米松治疗对大鼠膈肌结构和功能的性别特异性影响。
DOI:
10.1152/jappl.1997.82.1.125
发表时间:
1997
期刊:
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子:
--
作者:
[Prezant,DJ, Karwa,ML, Richner,B, Maggiore,D, Gentry,EI, Cahill,J]
通讯作者:
Cahill,J
Short- and long-term effects of testosterone on diaphragm in castrated and normal male rats.
睾酮对去势雄性大鼠和正常雄性大鼠膈肌的短期和长期影响。
DOI:
10.1152/jappl.1997.82.1.134
发表时间:
1997
期刊:
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子:
--
作者:
[Prezant,DJ, Karwa,ML, Kim,HH, Maggiore,D, Chung,V, Valentine,DE]
通讯作者:
Valentine,DE
Effects of short-term and long-term androgen treatment on the diaphragm in male and female rats.
短期和长期雄激素治疗对雄性和雌性大鼠膈肌的影响。
DOI:
10.1152/jappl.1993.75.3.1140
发表时间:
1993
期刊:
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子:
--
作者:
[Prezant,DJ, Valentine,DE, Gentry,EI, Richner,B, Cahill,J, Freeman,K]
通讯作者:
Freeman,K
Effect of long-term undernutrition on male and female rat diaphragm contractility, fatigue, and fiber types.
长期营养不良对雄性和雌性大鼠膈肌收缩力、疲劳和纤维类型的影响。
DOI:
10.1152/jappl.1994.76.4.1540
发表时间:
1994
期刊:
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子:
--
作者:
[Prezant,DJ, Richner,B, Aldrich,TK, Valentine,DE, Gentry,EI, Cahill,J]
通讯作者:
Cahill,J
Effects of starvation and refeeding on adult male rat diaphragm contractility, fatigue, and fiber types.
饥饿和再喂养对成年雄性大鼠膈肌收缩力、疲劳和纤维类型的影响。
DOI:
10.1152/jappl.1993.74.2.742
发表时间:
1993
期刊:
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子:
--
作者:
[Prezant,DJ, Valentine,DE, Kim,HH, Gentry,EI]
通讯作者:
Gentry,EI
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DIAPHRAGM ADAPTATIONS TO RESPIRATORY TRAINING
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项目类别:
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资助金额:$7.77万
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负责人:DAVID J PREZANT
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依托单位:
海外基金