CLINICAL EVALUATION OF THE VESTIBULO-OCULASR REFLEX

前庭眼反射的临床评估

• 批准号: 3083574
• 负责人: Timothy C Hain
• 金额: $ 7.08万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-07-01 至 1990-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3083574
• 关键词: body movement; ear disorder diagnosis; electrooculography; eye movements; head movements; human subject; labyrinth disorder; magnetic field; neurophysiology; nystagmus; stimulus /response; vertigo; vestibular apparatus; vestibuloocular reflex; vision disorders

The long term objective of our research is to better understand the mechanisms underlying both normal and abnormal vestibulo-ocular function. The aim of the present proposal is to develop new ways of testing and analyzing the vestibulo-ocular reflex (VOR). The research strategy is to make quantitative measurements of vestibulo-ocular function in humans using paradigms suggested by the results of both recent neurophysiological studies as well as mathematical analyses of VOR function. In particular, we will choose rotational vestibular and optokinetic stimuli that exceed the capabilities of or circumvent the compensatory mechanisms which normally make vestibular diagnosis so difficult. We will begin by applying the new methodology to the detection of unilateral peripheral vestibular disease (UPVD)--first in patients with complete loss, then those with partial loss--with the ultimate plan to extend our results to patients with central vestibular disorders. We plan to 1) use brief, high-velocity head-on-body movements to expose UPVD, 2) determine (with the magnetic field search coil technique) if inappropriately directed slow phase eye movements during high-velocity vertical or horizontal head rotations are a reliable index to UPVD, 3) develop a new test to measure vertical semicircular canal function by using their contribution to the horizontal (eye in head) VOR, 4) use the initial slow phase velocity profile (plateau effect), in response to a constant velocity head rotation, to detect UPVD and 5) examine the usefulness of optokinetic afternystagmus (OKAN) in assessment of UPVD. Our results will provide new information useful in the assessment of the large number of patients with nystagmus, visual blurring and oscillopsia, and vertigo and dizziness.

我们研究的长期目标是更好地了解 正常和异常前庭眼功能的潜在机制。 本提案的目的是开发新的测试方法， 前庭眼反射（vestibulo-ocular reflex，VOR） 研究策略是 使用以下方法对人类前庭眼功能进行定量测量： 最近的神经生理学结果表明， 研究以及VOR函数的数学分析。 特别是， 我们将选择旋转前庭和视动刺激， 或规避补偿机制的能力， 通常会让前庭诊断变得很困难 我们将开始申请 单侧外周前庭神经病变的新检测方法 疾病（UPVD）-首先是完全丧失的患者，然后是 部分损失-最终计划将我们的结果扩展到患者， 中枢性前庭障碍 我们计划1）使用简短，高速 头对身体的运动，以暴露UPVD，2）确定（与磁 场搜索线圈技术），如果不适当地指向慢相位眼 在高速垂直或水平头部旋转期间的运动是 建立了一种新的测量垂直方向的方法， 半规管的功能，通过使用他们的贡献，水平 (eye 4）使用初始慢相速度分布（平台 效应），以检测UPVD 和5）检查视动性后眼震（OKAN）在 评估UPVD。 我们的研究结果将提供新的信息， 评估大量患者的眼球震颤、视物模糊 以及眩晕和晕眩。