CLINICAL EVALUATION OF THE VESTIBULO-OCULAR REFLEX

前庭眼反射的临床评估

• 批准号: 3260643
• 负责人: Timothy C Hain
• 金额: $ 6.24万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-07-01 至 1991-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3260643
• 关键词: computer assisted diagnosis; diagnosis design /evaluation; ear disorder diagnosis; eye movements; head movements; heat stimulus; human subject; labyrinth disorder; mathematical model; neurologic manifestations; neurophysiology; nystagmus; otocyst /otolith; reflex; stimulus /response; vertigo; vestibular apparatus; vestibuloocular reflex

The long term objective of our research is to better understand the mechanisms underlying both normal and abnormal vestibular function. The focus of this proposal is to develop and refine methodology for detection of lesions of the semicircular canals and of the otoliths. The research strategy is to make quantitative measurements of vestibulo-ocular and vestibulo-spinal function in humans using paradigms suggested by the results of neuro- physiological studies and mathematical models of vestibular function. We will study normal human subjects and compare their response to those of patients with known vestibular lesions. The first project aims to detect lesions of the vertical semicircular canals. We will detect unilateral lesions through caloric irrigation with the head pitched to make the lateral canals horizontal. We will measure the vestibulo-ocular response to the caloric irrigation using the scleral eye coil and the vestibulo- spinal response using posturography. We will detect bilateral lesions and/or central lesions through measurement of the entire vector of the VOR, that is, horizontal, vertical and torsional eye movement, as elicited by rotational stimuli that excite the vertical canals. Our second project aims to refine methods of detecting lesions of the lateral canals. To detect unilateral lesions we will quantify head-shaking nystagmus in patients with peripheral or central vestibular lesions. We will also investigate a new form of head- shaking that excites the vertical canals, circular head shaking. Our third project aims to detect lesions of the otoliths. We will investigate the effects of eccentric rotation with one ear lateral to the axis of rotation to selectively stimulate a single otolith organ. We will use eccentric rotation with both ears anterior to the axis of rotation to stimulate both otoliths. We will measure the modulation gain and time constant of the VOR. Our results will provide new information useful in the assessment of patients with nystagmus, visual blurring and oscillopsia, vertigo dizziness, and disequilibrium.

我们研究的长期目标是更好地了解 正常和异常前庭的机制 功能 这一建议的重点是发展和完善 半规管病变的检测方法 和耳石的痕迹 研究策略是使定量 前庭-眼和前庭-脊髓功能的测量 人类使用的范式所建议的结果，神经， 前庭的生理研究和数学模型 功能 我们将研究正常的人类受试者， 已知前庭病变患者的反应。 第一个项目的目的是检测病变的垂直 半规管 我们将检测单侧病变， 头部倾斜进行热灌注，以形成侧管 水平的。 我们将测量前庭眼反应， 使用巩膜眼线圈和前庭进行热量冲洗， 用姿势描记法测量脊髓反应。 我们会发现 病变和/或中央病变，通过测量整个 VOR矢量，即水平、垂直和扭转眼 运动，如由旋转刺激引起的， 垂直运河 我们的第二个项目旨在改进检测 侧运河。 为了检测单侧病变，我们将量化 周围性或中枢性震颤患者的摇头性眼球震颤 前庭病变 我们还将研究一种新的头部- 震动激发了垂直的管道，圆形的头部晃动。 我们的第三个项目旨在检测耳石的病变。 我们将 探讨偏心旋转与一侧耳朵的影响 以选择性地刺激单个耳石 器官. 我们将使用偏心旋转与两耳前， 旋转轴刺激两个耳石。 我们将测量 VOR的调制增益和时间常数。 我们的研究结果将为评估提供有用的新信息 眼震、视物模糊、视物模糊、眩晕 头晕和失衡