CLINICAL EVALUATION OF THE VESTIBULO-OCULAR REFLEX

前庭眼反射的临床评估

• 批准号: 3260646
• 负责人: Timothy C Hain
• 金额: $ 4.43万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-07-01 至 1991-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3260646
• 关键词: computer assisted diagnosis; diagnosis design /evaluation; ear disorder diagnosis; eye movements; head movements; heat stimulus; human subject; labyrinth disorder; mathematical model; neurologic manifestations; neurophysiology; nystagmus; otocyst /otolith; reflex; stimulus /response; vertigo; vestibular apparatus; vestibuloocular reflex

The long term objective of our research is to better understand the mechanisms underlying both normal and abnormal vestibular function. The focus of this proposal is to develop and refine methodology for detection of lesions of the semicircular canals and of the otoliths. The research strategy is to make quantitative measurements of vestibulo-ocular and vestibulo-spinal function in humans using paradigms suggested by the results of neuro- physiological studies and mathematical models of vestibular function. We will study normal human subjects and compare their response to those of patients with known vestibular lesions. The first project aims to detect lesions of the vertical semicircular canals. We will detect unilateral lesions through caloric irrigation with the head pitched to make the lateral canals horizontal. We will measure the vestibulo-ocular response to the caloric irrigation using the scleral eye coil and the vestibulo- spinal response using posturography. We will detect bilateral lesions and/or central lesions through measurement of the entire vector of the VOR, that is, horizontal, vertical and torsional eye movement, as elicited by rotational stimuli that excite the vertical canals. Our second project aims to refine methods of detecting lesions of the lateral canals. To detect unilateral lesions we will quantify head-shaking nystagmus in patients with peripheral or central vestibular lesions. We will also investigate a new form of head- shaking that excites the vertical canals, circular head shaking. Our third project aims to detect lesions of the otoliths. We will investigate the effects of eccentric rotation with one ear lateral to the axis of rotation to selectively stimulate a single otolith organ. We will use eccentric rotation with both ears anterior to the axis of rotation to stimulate both otoliths. We will measure the modulation gain and time constant of the VOR. Our results will provide new information useful in the assessment of patients with nystagmus, visual blurring and oscillopsia, vertigo dizziness, and disequilibrium.

我们研究的长期目标是更好地理解 正常前庭和异常前庭的机制 功能。这项建议的重点是开发和完善 半规管病变的检测方法 还有耳石。研究策略是数量化 老年人前庭眼球和前庭脊髓功能的测量 人类使用神经学结果所提出的范例-- 前庭的生理研究和数学模型 功能。我们将研究正常的人类对象并比较他们的 对已知前庭病变的患者的反应。 第一个项目旨在检测垂直方向的病变 半规管。我们将通过以下方式检测单侧病变 头部倾斜以形成侧向根管的热量灌溉 水平方向。我们将测量前庭-眼睛对 使用巩膜眼圈和前庭进行热量冲洗- 使用姿势描记术的脊柱反应。我们将检测到双边 病变和/或中心性病变通过测量整个 VOR的矢量，即水平、垂直和扭转的眼睛 运动，如由刺激运动的旋转刺激引起的运动 垂直运河。 我们的第二个项目旨在改进检测病变的方法 侧向的运河。为了检测单侧病变，我们将量化 周围型或中枢型患者的摇头性眼球震颤 前庭病变。我们还将研究一种新的头部形式-- 摇晃会刺激垂直的沟渠，圆头摇晃。 我们的第三个项目旨在检测耳石的损伤。我们会 单耳侧向偏心旋转的效果观察 到旋转轴以选择性地刺激单个耳石 管风琴。我们将使用偏心旋转，双耳朝前 刺激两个耳石的旋转轴。我们将衡量 VOR的调制增益和时间常数。 我们的结果将为评估提供新的有用信息 有眼球震颤、视力模糊和视振荡、眩晕的患者 头晕，身体不平衡。