MOLECULAR GENETICS TRAINING: RIBOSOMAL GENE EXPRESSION

提出了一个建议，在分子遗传学的医生的培训。 该提案将使申请人成为一个富有成效的，独立的 人类遗传学分子方面的研究员。 的手段 在一个支持性的，刺激性的环境中发展为研究人员， 宾夕法尼亚大学人类遗传学系的建议。 本提案中进行的研究将针对 理解基因表达的转录控制， 研究人类核糖体基因的转录。 的 核糖体基因的表达是细胞生长的组成部分， 发展，并在各种生理和病理改变 条件 了解核糖体基因的转录将 提供了一个基础，了解基因表达的变化， 癌症、衰老、生长和分化。 申请人是儿科遗传学家，将有机会 在分子指导下的基础科学培训 遗传学家 申请人的进展将被审查，并指导 由人类遗传学系委员会提供。 委员会将审查 申请人的培训，建议进一步培训，并判断 完成项目的第一阶段。 根据判断， 由委员会，将启动第二阶段和独立的生物 实验 委员会将定期审查这项工作， 完成并与申请人进行正式和非正式的会面。

A proposal is made for the training of a physician in molecular genetics. This proposal will prepare the applicant as a productive, independent researcher in the molecular aspects of human genetics. The means for the development as a researcher in a supportive, stimulating environment at the University of Pennsylvania in the Department of Human Genetics is proposed. The research undertaken in this proposal will be directed towards the understanding of transcriptional control of gene expression by investigating the transcription of the human ribosomal genes. The expression of the ribosomal genes is integral to cell growth and development, and is altered in a wide variety of physiologic and pathologic conditions. Understanding the transcription of the ribosomal genes will provide a basis in understanding the alterations in gene expression in cancer, senescence, growth and differentiation. The applicant is a pediatric geneticist who will have the opportunity for training in the basic sciences under the guidance of a molecular geneticist. The applicant's progress will be reviewed, and guidance provided by a Human Genetics Faculty Committee. The committee will review the applicant's training, recommend further training, and judge the completion of Phase I of the proposal. Completion of that phase, as judged by the committee, will initiate Phase II and independent biological experiments. The committee will regularly review that work to its completion and meet with the applicant on a formal and informal level.