INNER EAR FLUID DYNAMICS IN HEALTH AND DISEASE
INNER EAR FLUID DYNAMICS IN HEALTH AND DISEASE
批准号:
3094865
负责人:
RUEDIGER R THALMANN
金额:
$43.87万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1986
资助国家:
美国
项目状态:
已结题
起止时间:
1986-12-01 至 1991-11-30
中文摘要
这个项目的主要主题在我们的标题中表达了出来。
我们的最终目标是为理性的
门杰尔氏病及其他疾病的治疗探讨
内耳积液紊乱。为了实现这一目标,
内部流体动力学的基本机制
必须首先加以澄清。这项研究包括五个部分
子项目,范围从内部的基本离子传输机制
耳上皮细胞与临床相关的适应性研究
半圆形对流体动力学干扰的响应
运河。项目1涉及使用一种新的示踪剂技术来
直接测量不同年龄组内淋巴的流量和体积
内耳的一部分。项目#2通过以下方式补充项目#1
检查导致产生的化学因素
积水与甘油的暂时有益作用
脱水。在项目3中,最基本的蜂窝
钾的分泌和钾的产生的机制
内淋巴潜伏期将在黑质细胞区域进行研究。
椭圆体。项目4旨在阐明
覆盖膜的化学性质及其类似物
前庭系统的上层建筑。除了严格的
盖层中胶原类型(S)的表征
膜及相关构筑物的数量和分布
糖胺多聚糖和糖蛋白将通过
定量分析和特殊常规组织学
覆盖膜的制备。
英文摘要
The major theme of this program project is expressed in our title.
Our ultimate goal is to provide a basic foundation for a rational
approach to the management of Menjere's disease and other
disorders of inner ear fluids. In order to achieve this goal, the
fundamental mechanisms underlying fluid dynamics in the inner
must first be elucidated. This research, covered in five
subprojects, ranges from basic ion transport mechanisms in inner
ear epithelia to clinically relevant studies of the adaptive
response to interferences with fluid dynamics of the semicircular
canals. Project #1 involves the use of a novel tracer technique to
measure directly the flow and volume of endolymph in different
parts of the inner ear. Project #2 complements project #1 by
examining the chemical factors responsible for generation of
hydrops and the temporary beneficial effects of glycerol
dehydration. In project #3, the most fundamental cellular
mechanisms involved in secretion of K and generation of the
endolymphatic potential will be studied in the dark cell region of
the utricle. Project #4 is aimed at the elucidation of the
chemical nature of the tectorial membrane and analogous
superstructures of the vestibular system. In addition to a rigorous
characterization of the type(s) of collagen in the tectorial
membrane and related structures, the amount and distribution of
glycosaminoglycans and glycoproteins will be studied by
quantitative analytical and special conventional histological
preparations of the tectorial membrane.
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会议论文
Molecular Characterization of Key Proteins Directing Otoconial Mineralization
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批准号:8460865
-
项目类别:
-
资助金额:$36.7万
-
财政年份:2011
-
负责人:RUEDIGER R THALMANN
-
依托单位:
Molecular Characterization of Key Proteins Directing Otoconial Mineralization
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批准号:8263376
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项目类别:
-
资助金额:$39.54万
-
财政年份:2011
-
负责人:RUEDIGER R THALMANN
-
依托单位:
Molecular Characterization of Key Proteins Directing Otoconial Mineralization
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批准号:8086834
-
项目类别:
-
资助金额:$40.88万
-
财政年份:2011
-
负责人:RUEDIGER R THALMANN
-
依托单位:
INTERPLAY OF BIOLOGICAL AND PHYSICAL PROCESSES IN OTOCONIAL MORPHOGENESIS
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批准号:7640829
-
项目类别:
-
资助金额:$19.0万
-
财政年份:2008
-
负责人:RUEDIGER R THALMANN
-
依托单位:
INTERPLAY OF BIOLOGICAL AND PHYSICAL PROCESSES IN OTOCONIAL MORPHOGENESIS
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批准号:7532713
-
项目类别:
-
资助金额:$22.8万
-
财政年份:2008
-
负责人:RUEDIGER R THALMANN
-
依托单位:
PROTEINS OF ORGAN OF CORTI AND SURROUNDING FLUIDS
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批准号:2126490
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项目类别:
-
资助金额:$33.64万
-
财政年份:1992
-
负责人:RUEDIGER R THALMANN
-
依托单位:
PROTEINS OF ORGAN OF CORTI AND SURROUNDING FLUIDS
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批准号:3218093
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项目类别:
-
资助金额:$29.83万
-
财政年份:1992
-
负责人:RUEDIGER R THALMANN
-
依托单位:
PROTEINS OF ORGAN OF CORTI AND SURROUNDING FLUIDS
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批准号:3218094
-
项目类别:
-
资助金额:$0.52万
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财政年份:1992
-
负责人:RUEDIGER R THALMANN
-
依托单位:
PROTEINS OF ORGAN OF CORTI AND SURROUNDING FLUIDS
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批准号:3218095
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项目类别:
-
资助金额:$32.34万
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财政年份:1992
-
负责人:RUEDIGER R THALMANN
-
依托单位:
INNER EAR FLUID DYNAMICS IN HEALTH AND DISEASE
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批准号:3100136
-
项目类别:
-
资助金额:$58.49万
-
财政年份:1986
-
负责人:RUEDIGER R THALMANN
-
依托单位:
INNER EAR FLUID DYNAMICS IN HEALTH AND DISEASE
-
批准号:3100137
-
项目类别:
-
资助金额:$50.35万
-
财政年份:1986
-
负责人:RUEDIGER R THALMANN
-
依托单位:
INNER EAR FLUID DYNAMICS IN HEALTH AND DISEASE
-
批准号:3094867
-
项目类别:
-
资助金额:$48.87万
-
财政年份:1986
-
负责人:RUEDIGER R THALMANN
-
依托单位:
INNER EAR FLUID DYNAMICS IN HEALTH AND DISEASE
-
批准号:3094866
-
项目类别:
-
资助金额:$51.2万
-
财政年份:1986
-
负责人:RUEDIGER R THALMANN
-
依托单位:
METABOLIC PROCESSES OF THE INNER EAR
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批准号:3393484
-
项目类别:
-
资助金额:$26.29万
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财政年份:1975
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负责人:RUEDIGER R THALMANN
-
依托单位:
METABOLIC PROCESSES OF THE INNER EAR
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批准号:3393483
-
项目类别:
-
资助金额:$23.91万
-
财政年份:1975
-
负责人:RUEDIGER R THALMANN
-
依托单位:
国内基金
海外基金
细胞转录因子Ovol2对小鼠胎盘Labyrinth发育的功能研究
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批准号:31301195
-
项目类别:青年科学基金项目
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资助金额:21.0万元
-
批准年份:2013
-
负责人:祝冬梅
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依托单位: