INNER EAR FLUID DYNAMICS IN HEALTH AND DISEASE

健康和疾病中的内耳流体动力学

• 批准号: 3094865
• 负责人: RUEDIGER R THALMANN
• 金额: $ 43.87万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-12-01 至 1991-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3094865
• 关键词: fluidity; labyrinth

The major theme of this program project is expressed in our title. Our ultimate goal is to provide a basic foundation for a rational approach to the management of Menjere's disease and other disorders of inner ear fluids. In order to achieve this goal, the fundamental mechanisms underlying fluid dynamics in the inner must first be elucidated. This research, covered in five subprojects, ranges from basic ion transport mechanisms in inner ear epithelia to clinically relevant studies of the adaptive response to interferences with fluid dynamics of the semicircular canals. Project #1 involves the use of a novel tracer technique to measure directly the flow and volume of endolymph in different parts of the inner ear. Project #2 complements project #1 by examining the chemical factors responsible for generation of hydrops and the temporary beneficial effects of glycerol dehydration. In project #3, the most fundamental cellular mechanisms involved in secretion of K and generation of the endolymphatic potential will be studied in the dark cell region of the utricle. Project #4 is aimed at the elucidation of the chemical nature of the tectorial membrane and analogous superstructures of the vestibular system. In addition to a rigorous characterization of the type(s) of collagen in the tectorial membrane and related structures, the amount and distribution of glycosaminoglycans and glycoproteins will be studied by quantitative analytical and special conventional histological preparations of the tectorial membrane.

这个项目的主要主题在我们的标题中表达了出来。 我们的最终目标是为理性的 门杰尔氏病及其他疾病的治疗探讨 内耳积液紊乱。为了实现这一目标， 内部流体动力学的基本机制 必须首先加以澄清。这项研究包括五个部分 子项目，范围从内部的基本离子传输机制 耳上皮细胞与临床相关的适应性研究 半圆形对流体动力学干扰的响应 运河。项目1涉及使用一种新的示踪剂技术来 直接测量不同年龄组内淋巴的流量和体积 内耳的一部分。项目#2通过以下方式补充项目#1 检查导致产生的化学因素 积水与甘油的暂时有益作用 脱水。在项目3中，最基本的蜂窝 钾的分泌和钾的产生的机制 内淋巴潜伏期将在黑质细胞区域进行研究。 椭圆体。项目4旨在阐明 覆盖膜的化学性质及其类似物 前庭系统的上层建筑。除了严格的 盖层中胶原类型(S)的表征 膜及相关构筑物的数量和分布 糖胺多聚糖和糖蛋白将通过 定量分析和特殊常规组织学 覆盖膜的制备。