INNER EAR FLUID DYNAMICS IN HEALTH AND DISEASE
INNER EAR FLUID DYNAMICS IN HEALTH AND DISEASE
批准号:
3094865
负责人:
RUEDIGER R THALMANN
金额:
$43.87万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1986
资助国家:
美国
项目状态:
已结题
起止时间:
1986-12-01 至 1991-11-30
中文摘要
这个项目的主要主题在我们的标题中表达出来。
我们的最终目标是提供一个基本的基础,
治疗门杰尔病和其他疾病的方法
内耳液体紊乱。 为了实现这一目标,
内部流体动力学的基本机制
必须首先阐明。 这项研究,涵盖在五个
子项目,范围从基本的离子传输机制,在内部
耳上皮细胞的临床相关研究的适应性
对半圆形流体动力学干扰的响应
运河 项目#1涉及使用一种新的示踪技术,
直接测量不同部位内淋巴流量和体积,
内耳的一部分。 项目2通过以下方式补充项目1
检查化学因素负责产生的
水肿和甘油的暂时有益作用
脱水 在项目#3中,最基本的细胞
参与K分泌和产生的机制,
内淋巴电位将在暗细胞区域进行研究,
胞果 项目#4旨在阐明
覆膜和类似物的化学性质
前庭系统的上层结构。 除了严格的
顶盖中胶原类型的表征
膜和相关结构,
糖胺聚糖和糖蛋白的研究将通过
定量分析和特殊常规组织学
覆膜的制备。
英文摘要
The major theme of this program project is expressed in our title.
Our ultimate goal is to provide a basic foundation for a rational
approach to the management of Menjere's disease and other
disorders of inner ear fluids. In order to achieve this goal, the
fundamental mechanisms underlying fluid dynamics in the inner
must first be elucidated. This research, covered in five
subprojects, ranges from basic ion transport mechanisms in inner
ear epithelia to clinically relevant studies of the adaptive
response to interferences with fluid dynamics of the semicircular
canals. Project #1 involves the use of a novel tracer technique to
measure directly the flow and volume of endolymph in different
parts of the inner ear. Project #2 complements project #1 by
examining the chemical factors responsible for generation of
hydrops and the temporary beneficial effects of glycerol
dehydration. In project #3, the most fundamental cellular
mechanisms involved in secretion of K and generation of the
endolymphatic potential will be studied in the dark cell region of
the utricle. Project #4 is aimed at the elucidation of the
chemical nature of the tectorial membrane and analogous
superstructures of the vestibular system. In addition to a rigorous
characterization of the type(s) of collagen in the tectorial
membrane and related structures, the amount and distribution of
glycosaminoglycans and glycoproteins will be studied by
quantitative analytical and special conventional histological
preparations of the tectorial membrane.
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会议论文
Molecular Characterization of Key Proteins Directing Otoconial Mineralization
-
批准号:8460865
-
项目类别:
-
资助金额:$36.7万
-
财政年份:2011
-
负责人:RUEDIGER R THALMANN
-
依托单位:
Molecular Characterization of Key Proteins Directing Otoconial Mineralization
-
批准号:8263376
-
项目类别:
-
资助金额:$39.54万
-
财政年份:2011
-
负责人:RUEDIGER R THALMANN
-
依托单位:
Molecular Characterization of Key Proteins Directing Otoconial Mineralization
-
批准号:8086834
-
项目类别:
-
资助金额:$40.88万
-
财政年份:2011
-
负责人:RUEDIGER R THALMANN
-
依托单位:
INTERPLAY OF BIOLOGICAL AND PHYSICAL PROCESSES IN OTOCONIAL MORPHOGENESIS
-
批准号:7640829
-
项目类别:
-
资助金额:$19.0万
-
财政年份:2008
-
负责人:RUEDIGER R THALMANN
-
依托单位:
INTERPLAY OF BIOLOGICAL AND PHYSICAL PROCESSES IN OTOCONIAL MORPHOGENESIS
-
批准号:7532713
-
项目类别:
-
资助金额:$22.8万
-
财政年份:2008
-
负责人:RUEDIGER R THALMANN
-
依托单位:
PROTEINS OF ORGAN OF CORTI AND SURROUNDING FLUIDS
-
批准号:2126490
-
项目类别:
-
资助金额:$33.64万
-
财政年份:1992
-
负责人:RUEDIGER R THALMANN
-
依托单位:
PROTEINS OF ORGAN OF CORTI AND SURROUNDING FLUIDS
-
批准号:3218093
-
项目类别:
-
资助金额:$29.83万
-
财政年份:1992
-
负责人:RUEDIGER R THALMANN
-
依托单位:
PROTEINS OF ORGAN OF CORTI AND SURROUNDING FLUIDS
-
批准号:3218094
-
项目类别:
-
资助金额:$0.52万
-
财政年份:1992
-
负责人:RUEDIGER R THALMANN
-
依托单位:
PROTEINS OF ORGAN OF CORTI AND SURROUNDING FLUIDS
-
批准号:3218095
-
项目类别:
-
资助金额:$32.34万
-
财政年份:1992
-
负责人:RUEDIGER R THALMANN
-
依托单位:
INNER EAR FLUID DYNAMICS IN HEALTH AND DISEASE
-
批准号:3100136
-
项目类别:
-
资助金额:$58.49万
-
财政年份:1986
-
负责人:RUEDIGER R THALMANN
-
依托单位:
INNER EAR FLUID DYNAMICS IN HEALTH AND DISEASE
-
批准号:3100137
-
项目类别:
-
资助金额:$50.35万
-
财政年份:1986
-
负责人:RUEDIGER R THALMANN
-
依托单位:
INNER EAR FLUID DYNAMICS IN HEALTH AND DISEASE
-
批准号:3094867
-
项目类别:
-
资助金额:$48.87万
-
财政年份:1986
-
负责人:RUEDIGER R THALMANN
-
依托单位:
INNER EAR FLUID DYNAMICS IN HEALTH AND DISEASE
-
批准号:3094866
-
项目类别:
-
资助金额:$51.2万
-
财政年份:1986
-
负责人:RUEDIGER R THALMANN
-
依托单位:
METABOLIC PROCESSES OF THE INNER EAR
-
批准号:3393484
-
项目类别:
-
资助金额:$26.29万
-
财政年份:1975
-
负责人:RUEDIGER R THALMANN
-
依托单位:
METABOLIC PROCESSES OF THE INNER EAR
-
批准号:3393483
-
项目类别:
-
资助金额:$23.91万
-
财政年份:1975
-
负责人:RUEDIGER R THALMANN
-
依托单位:
国内基金
海外基金
细胞转录因子Ovol2对小鼠胎盘Labyrinth发育的功能研究
-
批准号:31301195
-
项目类别:青年科学基金项目
-
资助金额:21.0万元
-
批准年份:2013
-
负责人:祝冬梅
-
依托单位: