DEAFFERATION AND TRIGEMINAL AFFERENT PROJECTIONS

我们已经完成了对成人的影响的检查 眶下横断术对三叉神经生理学的影响 神经节细胞。458个神经节细胞 至少用玻璃或钨微电极记录在60 IO神经切断后数天。我们发现这一次受伤 结果是1)伤害性单位的数量增加，2)a 对无害药物敏感的细胞相对百分比的变化 刺激，3)多个感受野异常的细胞和4) 上颌骨分区内地形的显著改变。 总IO触觉单位的百分比从正常下降 值从77%增加到28%，而守卫头发单位从12%增加到28% 在正常动物中为36%。同时，该百分比 IO伤害性单位的百分比从正常值6%增加到 20%我们还遇到了15个由IO驱动的单元 刺激电极，但没有外周感受野(无 我们的正常单位都表现出了这一特征)。 除了伤害性和卫士数量的增加 毛发单位，成人IO神经横断也导致了一些 感受野异常的三叉神经节细胞。这些 不寻常的单位包括5个细胞具有不连续的感受性 场(两个响应挠度大于振动的场)，a 对触觉和周围护卫的移动敏感的单位 毛发和八个细胞只对深部压力有反应 IO孔区域。

We have completed an examination of the effects of adult infraorbital (IO) transection on the physiology of trigeminal ganglion cells. Four hundred fifty-eight ganglion cells were recorded with glass or tungsten microelectrodes at least at 60 days after IO nerve transection. We have found that this injury results in 1) an increase in the number of nociceptive units, 2) a shift in the relative percentages of cells sensitive to innocuous stimuli, 3) a number of cells with abnormal receptive fields and 4) a significant alteration of maxillary intradivisional topography. The percentage of total IO vibrissa units decreased from a normal value 77% to 28%, while the guard hair units increased from 12% in the normal animals to 36%. At the same time, the percentage of IO nociceptive units increased from the normal value of 6% to 20%. We also encountered 15 units which were driven by the IO stimulating electrode but had not peripheral receptive field (none of our normal units exhibited this characteristic). In addition to an increase in the number of nociceptive and guard hair units, adult IO nerve transection also resulted in a number of trigeminal ganglion cells with abnormal receptive fields. These unusual units included five cells with discontinuous receptive fields (two responding to deflection of more than on vibrissa), a unit sensitive to movement of a vibrissa and surrounding guard hairs and eight cells that responded only to deep pressure in the region of the IO foramen.