COBRE: LOUISVILLE RES FOUND INC: P1: GLYCOLYSIS AND NEOPLASTIC GROWTH

点击翻译按钮获取中文摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. During the past 12 months, we have examined the metabolic and neoplastic requirements of PFKFB3 for ras transformation using a combination of siRNA and heterozygote genomic deletion technologies. We find that PFKFB3 expression is selectively necessary for the control of glycolytic flux in cells transformed with ras and propose that pharmacologic inhibition of PFKFB3 may affect the survival and growth of neoplastic cells (see Subproject Progress in this report).