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SICKLE CELL ANEMIA AND OTHER HEMOGLOBINOPATHIES

SICKLE CELL ANEMIA AND OTHER HEMOGLOBINOPATHIES
镰状细胞性贫血和其他血红蛋白病
批准号：
3097799
负责人：
Ronald L Nagel
金额：
$139.83万
依托单位：
ALBERT EINSTEIN COLLEGE OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
1982
资助国家：
美国
项目状态：
已结题
起止时间：
1982-06-01 至 1992-05-31
来源：
https://reporter.nih.gov/project-details/3097799
关键词：
hemoglobin Ss hemoglobinopathy molecular pathology sickle cell anemia sickling inhibitor

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中文摘要
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英文摘要
The present project intends to advance the understanding of the molecular basis of the polymerization of Hb S. We intend to investigate the pregelling events, the role of non-Hb S molecules, and the supramolecular structure of the polymer. We intend to pursue the kinetics of sickling, the ligand kinetics of Hb S containing red cells and the basis of the changes in the oxygen equilibrium curve in these cells. We will continue the development of nitrogen mustards and alkylureas as antisickling agents. We will also inquire into the basis of the stimulation of the synthesis of Hb F in some pathological states, with the hope of understanding its operative control.
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SICKLE CELL
SICKLE CELL
SICKLE CELL ANEMIA
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