NEURAL AND HUMORAL CONTROL OF ENDOCRINE FUNCTION

这是一份继续支持研究项目的申请 自1962年以来一直由项目资助。 的 对内分泌功能的神经和体液调节的研究 现在开始关注体内的肾素-血管紧张素系统， 与之相关的荷尔蒙。 本申请带来了 科学家们在动物生理学、细胞 生物学和分子遗传学， 由一个行政核心、一个实验室服务部门 核心和细胞培养核心。 项目1（项目编号：W.F.甘农）是 研究大脑在调节 循环血管紧张素II，特别强调 下丘脑对肾素分泌和神经内分泌控制 血管紧张素原的分泌。 第二个项目（P.I.：I.A.里德） 主要涉及加压素和 肾素分泌，包括交感神经系统 神经系统和心钠素参与了 相互作用，并与有趣的发现， 肾神经传入增加加压素分泌。 的 第三个项目（P.I.：C.F. Deschepper）是一项更广泛研究的一部分 对组织肾素-血管紧张素系统的影响，并应用免疫细胞化学， 分子和细胞培养技术来分析 脑血管紧张素系统的组成部分， 血管紧张素II在中枢神经系统中产生。 的 第四个项目（P.I.：M.K. Steele）关注的是 大脑中产生的血管紧张素II发挥其 影响，并采用神经内分泌模型来检验假设 大脑血管紧张素II在局部起作用， 去甲肾上腺素多巴胺和其他脑胺 它还 探讨了脑血管紧张素系统的功能， 调节垂体前叶的分泌。 的 第五保护（P.I.：朗格Eudelhuber）探讨了 肾素基因和血管紧张素原基因， 这种调节作用是对影响血管紧张素原和血管紧张素原的因素的调节， 分泌物 第六保护（P.I.：丹吉加德纳）探索了 心房钠尿肽基因在脑内的调节 与水电解质代谢的脑调节的关系 和心血管功能。 所要求的支助是 基础研究，但所有的项目都或多或少 与高血压、心力衰竭、糖尿病直接相关 尿崩症和各种其他心血管和内分泌疾病。

This is an application for continued support of a research program that has been supported by program project grants since 1962. The studies on neural and humoral regulation of endocrine function have now come to focus on the renin-angiotensin systems in the body and the hormones related to them. The present application brings together scientists with expertise in whole animal physiology, cell biology, and molecular genetics to work on six interrelated projects supported by an administrative core, a laboratory service core, and a cell culture core. Project 1 (P.l.: W.F. Ganong) is concerned with the role of the brain in the regulation of circulating angiotensin II, with particular emphasis on hypothalamic control of renin secretion and neuroendocrine control of angiotensinogen secretion. The second project (P.I.: I.A. Reid) is concerned primarily with the interaction between vasopressin and renin secretion, including the possibility that the sympathetic nervous system and atrial natriuretic peptide are involved in the interaction, and with the interesting discovery that stimulation of afferent renal nerves increases vasopressin secretion. The third project (P.I.: C.F. Deschepper) is part of a broader study on tissue renin-angiotensin systems and applies immunocytochemical, molecular, and cell culture techniques to an analysis of the components of the brain renin-angiotensin system and the way angiotensin II is generated in the central nervous system. The fourth project (P.I.: M.K. Steele) is concerned with the mechanism by which the angiotensin II produced in the brain exerts its effects, and employs neuroendocrine models to test the hypothesis that brain angiotensin II acts locally to facilitate the release of norepinephrine, dopamine, and other brain amines. It also explores the function of the brain renin-angiotensin system in the regulation of the secretion of the anterior pituitary gland. The fifth protect (P.I.: T.L. Reudelhuber) explores the regulation of the renin gene and the angiotensinogen gene in the rat and relates this regulation to the factors affecting renin and angiotensinogen secretion. The sixth protect (P.I.: D.G. Gardner) explores the regulation of the atrial natriuretic peptide gene in the brain in relation to brain regulation of fluid and electrolyte metabolism and cardiovascular function. The support requested is for fundamental research, but all the projects are more or less directly related to hypertension, heart failure, diabetes insipidus, and various other cardiovascular and endocrine diseases.