HYPOTHALAMIC-PITUITARY-ADRENAL AXIS REVISITED

重新审视下丘脑-垂体-肾上腺轴

• 批准号: 3434545
• 负责人: WILLIAM F GANONG
• 金额: $ 1万
• 依托单位: NEW YORK ACADEMY OF SCIENCES
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-04-01 至 1988-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3434545
• 关键词: health science research potential; hypothalamus; meeting /conference /symposium; pituitary adrenal axis

This is a request for funds to support a conference on the hypothalamic-pituitary-adrenal axis. Ten years ago, a multidisciplinary conference on ACTH and Related Peptides: Structure, Regulation and Action was held in New York. The proceedings of that conference, which was sponsored by the New York Academy of Sciences, were published in 1977 and attracted considerable attention. In the succeeding decade, the field has moved ahead in dramatic fashion. Dorothy T. Kreiger and William F. Ganong, who organized the 1976 conference, were working on a follow up conference when Dr. Kreiger died. Dr. Ganong and his associates, Mary F. Dallman and James L. Roberts now propose to convene the second New York Academy of Sciences conference on the subject as a memorial to Dr. Kreiger. The title of the conference will be The Hypothalamic-Pituitary- Adrenal Axis Revisited, and it will be held in New York, April 6-8, 1987. We plan to have 36 invited speakers. In addition, there will be a poster session so that a large number of additional investigators can be present. Like its predecesor, the conference will have a broad interdisciplinary base and will bring together experts on all aspects of the system from the molecular to the clinical. It will provide a detailed analysis of progress, new developments, and new dimensions in the field. At the time of the last conference, the structure of corticotropin releasing hormone (CRH, CRF) was unknown. Today it has been isolated, its structure has been elucidated, and the gene for CRH has been cloned. Another important discovery has been the demonstration that a variety of different substances have CRH activity. The probable existence of a large precursor molecule for ACTH was appreciated 10 years ago, but now the gene for pro- opiomelanocortin (POMC) has been cloned and its distribution in the body has been mapped. Additional progress has been made in the clinical area, and in understanding the neural pathways involved in the regulation of CRH secretion, elucidating the way ACTH acts on the adrenal cortex, and exploring the relationship of the hypothalamic-pituitary-adrenal system to the immune system. Therefore, it seem particularly appropriate to convene another multidisciplinary conference to review progress and foster scientific interchange.

这是一项资助会议的请求 下丘脑-垂体-肾上腺轴。 十年前，一个 ACTH 和相关肽多学科会议： 结构、监管和行动在纽约举行。 这 该会议的会议记录由新 约克科学院于 1977 年发表并吸引了 相当的关注。 在接下来的十年里，该领域已经 以戏剧性的方式向前推进。 多萝西·T·克雷格和威廉 1976 年会议的组织者 F. Ganong 正在研究一项 克雷格博士去世后的后续会议。 加农博士和他的 玛丽·F·达尔曼 (Mary F. Dallman) 和詹姆斯·L·罗伯茨 (James L. Roberts) 的合伙人现在提议 召开第二届纽约科学院会议 这个主题是为了纪念克赖格博士。 会议的标题是下丘脑-垂体- Adrenal Axis Revisited，将于 4 月 6 日至 8 日在纽约举行， 1987年。我们计划邀请36位演讲者。 此外，还将有 举办海报会议，以便大量额外的 调查人员可以在场。 与其前身一样，这次会议 将拥有广泛的跨学科基础并将汇集 从分子到系统各个方面的专家 临床。 它将提供详细的进展分析、新的 领域的发展和新维度。 当时 上次会议，促肾上腺皮质激素释放结构 激素（CRH、CRF）未知。 今天已经被隔离了 其结构已被阐明，CRH基因已被确定 克隆的。 另一个重要发现是演示 表明多种不同物质都具有CRH活性。 这 ACTH 的大前体分子的可能存在是 10年前就受到赞赏，但现在亲基因 阿片黑皮素 (POMC) 已被克隆并分布在 身体已被映射。 已取得额外进展 临床领域，以及了解神经通路 参与 CRH 分泌的调节，阐明其途径 ACTH作用于肾上腺皮质，并探讨其关系 下丘脑-垂体-肾上腺系统对免疫系统的影响 系统。 因此，召开这次会议似乎特别合适。 另一次多学科会议审查进展情况并 促进科学交流。