HYPOTHALAMIC-PITUITARY-ADRENAL AXIS REVISITED

这是一项资金申请，以支持一项关于 下丘脑-垂体-肾上腺轴。十年前，一个 促肾上腺皮质激素及相关肽多学科会议： 结构、规则和行动在纽约举行。这个 会议纪要，由《纽约时报》赞助 约克科学院于1977年出版并吸引了 相当多的关注。在接下来的十年里，该领域已经 以戏剧性的方式前进。多萝西·T·克里奇和威廉 F·加农是1976年会议的组织者，他当时正致力于 克里格医生去世时的后续会议。加农博士和他的 合伙人玛丽·F·达尔曼和詹姆斯·L·罗伯茨现在提议 召开第二届纽约科学院会议 作为对克里奇博士的纪念品。 会议的题目将是下丘脑-垂体- 肾上腺轴重现，将于4月6-8日在纽约举行， 1987年。我们计划邀请36位演讲者。此外，还将有 是一次海报会议，让大量的额外 调查人员可以在场。像它的前身一样，这次会议 将拥有广泛的跨学科基础，并将把 系统各方面的专家，从分子到 临床上的。它将提供对进展的详细分析，新的 发展，以及该领域的新层面。在那个时候 上一次会议，促肾上腺皮质激素释放的结构 激素(CRH、CRF)尚不清楚。今天它已经被孤立了， 其结构已被阐明，CRH基因已被克隆 克隆的。另一项重要发现是演示 说明多种不同的物质都具有CRH活性。这个 ACTH可能存在一个大的前体分子 在10年前很受欢迎，但现在有了亲- 阿片黑素皮质素(POMC)已被克隆并分布于 身体已经被映射了。在以下方面取得了更多进展 临床领域，以及对神经通路的理解 参与CRH分泌的调节，阐明其途径 ACTH作用于肾上腺皮质，并探讨两者之间的关系 下丘脑-垂体-肾上腺系统对免疫的影响 系统。因此，召开会议似乎特别合适。 另一次多学科会议，以审查进展和 促进科学交流。

This is a request for funds to support a conference on the hypothalamic-pituitary-adrenal axis. Ten years ago, a multidisciplinary conference on ACTH and Related Peptides: Structure, Regulation and Action was held in New York. The proceedings of that conference, which was sponsored by the New York Academy of Sciences, were published in 1977 and attracted considerable attention. In the succeeding decade, the field has moved ahead in dramatic fashion. Dorothy T. Kreiger and William F. Ganong, who organized the 1976 conference, were working on a follow up conference when Dr. Kreiger died. Dr. Ganong and his associates, Mary F. Dallman and James L. Roberts now propose to convene the second New York Academy of Sciences conference on the subject as a memorial to Dr. Kreiger. The title of the conference will be The Hypothalamic-Pituitary- Adrenal Axis Revisited, and it will be held in New York, April 6-8, 1987. We plan to have 36 invited speakers. In addition, there will be a poster session so that a large number of additional investigators can be present. Like its predecesor, the conference will have a broad interdisciplinary base and will bring together experts on all aspects of the system from the molecular to the clinical. It will provide a detailed analysis of progress, new developments, and new dimensions in the field. At the time of the last conference, the structure of corticotropin releasing hormone (CRH, CRF) was unknown. Today it has been isolated, its structure has been elucidated, and the gene for CRH has been cloned. Another important discovery has been the demonstration that a variety of different substances have CRH activity. The probable existence of a large precursor molecule for ACTH was appreciated 10 years ago, but now the gene for pro- opiomelanocortin (POMC) has been cloned and its distribution in the body has been mapped. Additional progress has been made in the clinical area, and in understanding the neural pathways involved in the regulation of CRH secretion, elucidating the way ACTH acts on the adrenal cortex, and exploring the relationship of the hypothalamic-pituitary-adrenal system to the immune system. Therefore, it seem particularly appropriate to convene another multidisciplinary conference to review progress and foster scientific interchange.