HYPOTHALAMIC-PITUITARY-ADRENAL AXIS REVISITED

这是一项关于资助召开一次 下丘脑垂体肾上腺轴 十年前，A ACTH和相关肽的多学科会议： 结构、管理和行动会议在纽约举行。 的 该会议由联合国新闻部主办， 约克科学院，发表于1977年，吸引了 相当注意。 在接下来的十年里，该领域 以戏剧性的方式前进。 多萝西·T克里奇和威廉 F.甘农组织了1976年的会议， 克里奇博士去世后的后续会议 加农博士和他的 同事，玛丽F。作者声明：James L.罗伯茨现在提议， 召开第二届纽约科学院会议， 作为对克里奇博士的纪念 会议的标题将是下丘脑-垂体-肾上腺素， 肾上腺轴再访，它将在纽约，4月6日至8日， 1987. 我们计划邀请36位演讲者。 此外还将 是一个海报会议，使大量的额外的 调查人员可以在场。 就像它的创始人一样， 将有一个广泛的跨学科基础，并将汇集 专家对系统的各个方面，从分子到 临床。 报告将详细分析进展情况， 发展，以及该领域的新领域。 发生时 上一次会议，促肾上腺皮质激素释放的结构， 激素（CRH、CRF）不详。 今天它已经被隔离， 它的结构已经被阐明，CRH的基因已经被 克隆的 另一个重要的发现是 许多不同的物质都有CRH活性 的 可能存在一个大的促肾上腺皮质激素前体分子， 10年前，人们对基因的理解是正确的，但现在， 阿黑皮素（POMC）已被克隆，其分布在 尸体已经被定位了 在以下方面取得了进一步进展： 在临床领域，在理解神经通路 参与调节CRH分泌，阐明了 促肾上腺皮质激素作用于肾上腺皮质，并探讨 下丘脑-垂体-肾上腺系统对免疫系统的影响 系统 因此，召开一次会议似乎特别合适， 另一次多学科会议，审查进展情况， 促进科学交流。

This is a request for funds to support a conference on the hypothalamic-pituitary-adrenal axis. Ten years ago, a multidisciplinary conference on ACTH and Related Peptides: Structure, Regulation and Action was held in New York. The proceedings of that conference, which was sponsored by the New York Academy of Sciences, were published in 1977 and attracted considerable attention. In the succeeding decade, the field has moved ahead in dramatic fashion. Dorothy T. Kreiger and William F. Ganong, who organized the 1976 conference, were working on a follow up conference when Dr. Kreiger died. Dr. Ganong and his associates, Mary F. Dallman and James L. Roberts now propose to convene the second New York Academy of Sciences conference on the subject as a memorial to Dr. Kreiger. The title of the conference will be The Hypothalamic-Pituitary- Adrenal Axis Revisited, and it will be held in New York, April 6-8, 1987. We plan to have 36 invited speakers. In addition, there will be a poster session so that a large number of additional investigators can be present. Like its predecesor, the conference will have a broad interdisciplinary base and will bring together experts on all aspects of the system from the molecular to the clinical. It will provide a detailed analysis of progress, new developments, and new dimensions in the field. At the time of the last conference, the structure of corticotropin releasing hormone (CRH, CRF) was unknown. Today it has been isolated, its structure has been elucidated, and the gene for CRH has been cloned. Another important discovery has been the demonstration that a variety of different substances have CRH activity. The probable existence of a large precursor molecule for ACTH was appreciated 10 years ago, but now the gene for pro- opiomelanocortin (POMC) has been cloned and its distribution in the body has been mapped. Additional progress has been made in the clinical area, and in understanding the neural pathways involved in the regulation of CRH secretion, elucidating the way ACTH acts on the adrenal cortex, and exploring the relationship of the hypothalamic-pituitary-adrenal system to the immune system. Therefore, it seem particularly appropriate to convene another multidisciplinary conference to review progress and foster scientific interchange.