NEURAL AND HUMORAL CONTROL OF ENDOCRINE FUNCTION

这是一份持续支持研究计划的申请 自 1962 年以来一直由计划项目赠款支持。 内分泌功能的神经和体液调节研究 现在重点关注体内的肾素-血管紧张素系统 与它们相关的荷尔蒙。 本申请带来 汇集了在整个动物生理学、细胞学方面具有专业知识的科学家 生物学和分子遗传学致力于六个相互关联的领域 由行政核心、实验室服务支持的项目 核心和细胞培养核心。 项目 1（公众号：W.F. Ganong）是 关注大脑在调节中的作用 循环血管紧张素 II，特别强调 下丘脑对肾素分泌的控制和神经内分泌的控制 血管紧张素原的分泌。 第二个项目（PI：I.A. Reid） 主要涉及加压素和加压素之间的相互作用 肾素分泌，包括交感神经的可能性 神经系统和心房钠尿肽参与 互动，并有一个有趣的发现，即刺激 传入肾神经的作用增加加压素的分泌。 的 第三个项目（主要负责人：C.F. Deschepper）是更广泛研究的一部分 组织肾素-血管紧张素系统并应用免疫细胞化学， 分子和细胞培养技术来分析 脑肾素-血管紧张素系统的组成及途径 血管紧张素 II 在中枢神经系统中产生。 的 第四个项目（主要负责人：M.K. Steele）涉及该机制 大脑中产生的血管紧张素II通过它发挥作用 效应，并采用神经内分泌模型来检验假设 大脑血管紧张素 II 局部作用以促进释放 去甲肾上腺素、多巴胺和其他脑胺。 它还 探讨大脑肾素-血管紧张素系统的功能 调节垂体前叶的分泌。 的 第五种保护（P.I.：T.L. Reudelhuber）探索了 大鼠肾素基因和血管紧张素原基因及其相关性 这种对影响肾素和血管紧张素原的因素的调节 分泌。 第六保护（P.I.：D.G. Gardner）探索 大脑中心房钠尿肽基因的调节 与脑部液体和电解质代谢调节的关系 和心血管功能。 请求的支持是为了 基础研究，但所有项目都或多或少 与高血压、心力衰竭、糖尿病直接相关 尿崩症以及各种其他心血管和内分泌疾病。

This is an application for continued support of a research program that has been supported by program project grants since 1962. The studies on neural and humoral regulation of endocrine function have now come to focus on the renin-angiotensin systems in the body and the hormones related to them. The present application brings together scientists with expertise in whole animal physiology, cell biology, and molecular genetics to work on six interrelated projects supported by an administrative core, a laboratory service core, and a cell culture core. Project 1 (P.l.: W.F. Ganong) is concerned with the role of the brain in the regulation of circulating angiotensin II, with particular emphasis on hypothalamic control of renin secretion and neuroendocrine control of angiotensinogen secretion. The second project (P.I.: I.A. Reid) is concerned primarily with the interaction between vasopressin and renin secretion, including the possibility that the sympathetic nervous system and atrial natriuretic peptide are involved in the interaction, and with the interesting discovery that stimulation of afferent renal nerves increases vasopressin secretion. The third project (P.I.: C.F. Deschepper) is part of a broader study on tissue renin-angiotensin systems and applies immunocytochemical, molecular, and cell culture techniques to an analysis of the components of the brain renin-angiotensin system and the way angiotensin II is generated in the central nervous system. The fourth project (P.I.: M.K. Steele) is concerned with the mechanism by which the angiotensin II produced in the brain exerts its effects, and employs neuroendocrine models to test the hypothesis that brain angiotensin II acts locally to facilitate the release of norepinephrine, dopamine, and other brain amines. It also explores the function of the brain renin-angiotensin system in the regulation of the secretion of the anterior pituitary gland. The fifth protect (P.I.: T.L. Reudelhuber) explores the regulation of the renin gene and the angiotensinogen gene in the rat and relates this regulation to the factors affecting renin and angiotensinogen secretion. The sixth protect (P.I.: D.G. Gardner) explores the regulation of the atrial natriuretic peptide gene in the brain in relation to brain regulation of fluid and electrolyte metabolism and cardiovascular function. The support requested is for fundamental research, but all the projects are more or less directly related to hypertension, heart failure, diabetes insipidus, and various other cardiovascular and endocrine diseases.