PET STUDY OF BIOCHEMISTRY AND METABOLISM OF THE CNS

一台正电子发射断层扫描(PET)设备已在 密歇根大学开发一种新的非侵入性方法 利用发射新陈代谢的正电子进行人脑研究 药理探头。专用TCC CS-30型医用回旋加速器 放化/放射性药物PCT-4600A断层扫描仪 设施和一个小型图像处理计算机设施将用于 正电子发射计算机断层扫描研究的表现和对现有核医学的补充 设施。 建议的研究涉及使用正电子发射探头15-0-C0， 15-0-H20、15-0-02、18-F-2-脱氧葡萄糖、11-C-BCNU、68-Ga-EDTA和 11-C-东莨菪碱研究脑血容量、血流量和脑分区 系数，氧气利用，葡萄糖利用，肿瘤摄取， 血脑屏障完整性和M受体。 亨廷顿病、癫痫、脑肿瘤、低张症患者 以及与中风、肌张力障碍相关的高渗性麻痹阶段， 橄榄桥小脑萎缩和老化在人脑中也会 学习。使用几种试剂对正常大脑的研究将继续进行。 将合成新的发射正电子的放射性药物和新的 将对标签技术进行调查。11-C-东方碱将是 可用于体内高比活性受体研究和 将开发用于氨基的11-C-胺环戊烷碳酸(ACPC) 酸摄取研究。 新的生理建模技术将被应用于地图绘制 受体位置。参数估计技术将发展到 从FDG代谢的动态PET研究中确定速率常数。

A Positron Emission Tomography (PET) Facility has been established at the University of Michigan for the development of a new, non-invasive approach to human brain research utilizing positron emitting metabolic and pharmacologic probes. A dedicated TCC CS-30 medical cyclotron, a TCC PCT-4600A tomographic scanner, the radiochemical/radiopharmaceutical facilities and a small image processing computer facility will be used in the performance of PET studies and complement the existing Nuclear Medicine facilities. Proposed studies involve the use of positron emitting probes 15-0-C0, 15-0-H20, 15-0-02, 18-F-2-deoxyglucose, 11-C-BCNU, 68-Ga-EDTA and 11-C-Scopolamine to study cerebral blood volume, blood flow and partition coefficients, oxygen utilization, glucose utilization, tumor uptake, blood-brain barrier integrity and muscarinic receptors respectively. Patients with Huntington's disease, epilepsy, brain tumors, the hypotonic and hypertonic phases of paralysis associated with stroke, dystonia, olivopontocerebellar atrophy and aging in the human brain will also be studied. Studies of the normal brain with several agents will continue. New positron-emitting radiopharmaceuticals will be synthesized and new labeling techniques will be investigated. 11-C-Scopolamine will be available for high specific activity in vivo receptor studies and 11-C-amine cyclopentane carbocylic acid (ACPC) will be developed for amino acid uptake studies. New physiological modeling techniques will be instituted for mapping receptor sites. Parameter estimation techniques will be developed to determine rate constants from dynamic PET studies of FDG metabolism.