CORE GRANT FOR VISION RESEARCH

43名视觉科学家申请资助5个研究模块 促进和加强视觉科学家之间的互动， 眼科研究所的各个学科。 模块 将通过提供个人研究计划的努力， 为研究人员无法参与的项目提供合作机会 专业知识、资金或技术能力。 .模块包括：形态学、组织培养/单克隆抗体、动物 实验室计算机应用与生物统计学。 的 形态学模块将提供光学和电子显微镜功能 以及用于组织化学和原位杂交的组织制备， 从而增加形态学技术的可用性， 生物化学家、药理学家和免疫学家， 为他们的研究提供形态数据。 组织培养/单克隆 抗体模块将协助PI选择适当的培养技术 和培养基以及产生眼源的特征性组织培养物， 并负责细胞融合和指定克隆的储存 用于单克隆抗体生产。 这种资源将增加 研究人员的主要专长和援助，在动物 手术技术和术后护理，麻醉管理， 药物，药物，抗原注射和漂白所需的 多克隆抗体生产。 实验室计算机应用 该模块将通过以下方式为个人和协作努力提供支持： 协助微型计算机与实验室设备的接口， 开发用于采集、处理和分析实验数据的软件 数据由微机系统。 生物统计学模块将提供 支持个人和合作努力， 临床医生和基础研究人员在研究设计的统计方面， 数据分析;主要模块的使用将在规划，设计， 临床研究的执行和研究的统计分析 数据 .这些单元的工作人员受过专业培训， 各自领域 每个模块都在一个 经验丰富的研究者。 模块头构成了 核心补助金管理委员会，向一个委员会负责， ERI研究单位负责人的高级调查员。

Funds are requested by 43 vision scientists to support 5 research modules to facilitate and enhance interaction among the vision scientists in the various disciplines represented at the Eye Research Institute. The modules will extend endeavors of individual research programs by providing collaborative opportunities for projects in which investigators do not have expertise, funding, or technical capabilities. . The modules are: Morphology, Tissue Culture/Monoclonal Antibody, Animal Resource, Laboratory Computer Applications, and Biostatistics. The Morphology Module will provide light and electron microscopy capabilities and tissue preparation for histochemistry and in situ hybridization, thereby increasing the availability of morphologic techniques to biochemists, pharmacologists, and immunologists who need correlative morphologic data for their research. The Tissue Culture/Monoclonal Antibody Module will assist PIs in selecting appropriate culture techniques and media and in producing characterized tissue cultures of ocular origin, and will be responsible for cell fusions and storage of designated clones for monoclonal antibody production. Such a resource will augment the research of investigators whose primary expertise and assistance in animal surgical techniques and postoperative care, administration of anesthesia, drugs, and medications, and antigen injections and bleedings required for polyclonal antibody production. The Laboratory Computer Applications Module will provide support to individual and collaborative efforts by assisting in interfacing of microcomputers with lab equipment and by developing software for gathering, processing, and analyzing experimental data by microcomputer systems. The Biostatistics Module will provide support to individual and collaborative efforts by assisting both clinicians and basic researchers in statistical aspects of study design and data analysis; principal module utilization will be in planning, design, and execution of clinical studies and in statistical analysis of research data. . The modules are staffed by personnel with specialized training in the respective fields. Each module is under the immediate supervision of an established, experienced investigator(s). The module heads constitute the Core Grant administrative committee, which is responsible to a committee of senior investigators who are ERI research unit heads.