CORE GRANT FOR VISION RESEARCH

一个由37名视觉科学家组成的小组要求资金支持 四个研究模块，将提供一个机制，以促进 并加强视觉科学家之间的互动， 眼科研究所的学科。 的 模块将扩展个人研究的研究努力 通过为项目提供合作机会， 调查人员没有专业知识，资金或技术 能力的 四个模块是：形态学，组织培养/单克隆 抗体、动物资源和实验室计算机 应用. 形态学模块将提供光线， 电子显微镜的能力，从而增加了 形态学技术对生物化学家的可用性， 药理学家和免疫学家需要相关的 为他们的研究提供形态数据。 组织 培养/单克隆抗体模块将协助PI选择 适当的组织培养技术和培养基， 表征眼源性组织培养物，并将 负责细胞融合和指定克隆的储存， 单克隆抗体生产。 这样的资源将增加 研究人员的主要专长在于其他方面， 技术. 动物资源模块将提供专业知识 动物外科技术和术后援助 护理、麻醉给药、给药和 药物，抗原注射和漂白所需的 多克隆抗体生产。 实验室计算机 应用模块将为个人和 通过协助与下列机构的联系， 微型计算机与实验室设备，并通过开发 用于收集、处理和分析实验数据的软件 数据由微机系统。 这些单元将配备受过专门培训的人员 在各自的领域。 每个模块都将在 由经验丰富的资深调查员监督 在那个地区。 单元负责人将构成核心补助金 行政委员会将负责 高级调查员委员会， ERI的研究单位。

Funds are requested by a group of 37 vision scientists to support four research modules that will provide a mechanism to facilitate and enhance interaction among the vision scientists in the various disciplines represented at the Eye Research Institute. The modules will extend research endeavors of individual research programs by providing collaborative opportunities for projects in which investigators do not have expertise, funding, or technical capabilities. The four module are: Morphology, Tissue Culture/Monoclonal Antibody, Animal Resource, and Laboratory Computer Applications. The Morphology Module will provide light and electron microscopy capabilities, thereby increasing the availability of morphological techniques to biochemists, pharmacologists, and immunologists who need correlative morphologic data for their research. The Tissue Culture/Monoclonal Antibody Module will assist PIs in selecting appropriate tissue culture techniques and media and in producing characterized tissue cultures of ocular origin, and will be responsible for cell fusions and storage of designated clones for monoclonal antibody production. Such a resource will augment the research of investigators who primary expertise lies in other technologies. The Animal Resource Module will provide expertise and assistance in animal surgical techniques and postoperative care, anesthesia administration, administration of drugs and medications, and antigen injections and bleedings required for polyclonal antibody production. The Laboratory Computer Applications Module will provide support to individual and collaborative efforts by assisting in the interfacing of microcomputers with laboratory equipment and by developing software for gathering, processing, and analyzing experimental data by microcomputer systems. The modules will be staffed by personnel with specialized training in the respective fields. Each module will be under the immediate supervision of a well-established investigator(s) have experience in that area. The module heads will constitute the Core Grant administrative committee, which will in turn be responsible for a committee of senior investigators comprising heads of the research units of ERI.