INTERDISCIPLINARY RESEARCH--IMMUNOLOGIC DISEASE

拟议的中心赠款是对CIRID持续资助的请求 正在进行的免疫学跨学科研究中心 在乔治敦大学。该中心作为一个功能公认的单位而存在 并在研究方面整合了各种计划， 教育和病人护理，以及在社区、外联、 技术转让和教育。总体建议的计划 该项目由代表基础科学的高级研究人员组成 和临床学科(儿科学、医学、神经病学、 生物化学、微生物学、生物统计学和社区医学) 他们都将自己的专业知识和资源集中在 提交CIRID拨款提案。目前的建议一直是 经过重大修订，并已作为计划项目编制 包括五个相互关联、相互依赖的研究 项目。其中四个项目(1-4)围绕中心 统一的主题成熟的免疫过程在 发育宿主及其在抗菌宿主防御中的作用。这个 需要检验的宽泛假设是缺陷或损害 在开发中的许多非特定的和特定的 免疫学参数可导致免疫妥协和 使发育中的宿主容易受到严重感染和疾病。 这些项目包括对吞噬细胞发育的研究。 新生儿的功能(项目1)，结构和功能 补语第三成分研究(方案2)， 分泌型IgA系统的发育研究(项目3)， 发育中的免疫系统对病毒和病毒反应的研究 髓鞘抗原(项目4)；第五个项目社区外联 技术转让和教育包括儿童哮喘 利用自我管理技术的病人教育项目。

The proposed Center Grant is a request for continued CIRID funding of an ongoing Center for Interdisciplinary Studies of Immunology at Georgetown. The Center exists as a functionally recognized unit of the University and has integrated programs in research, education and patient care, as well as in community, outreach, technology transfer and education. The overall proposed program project consists of senior investigators representing basic science and clinical disciplines (pediatrics, medicine, neurology, biochemistry, microbiology, biostatistics, and community medicine) all of whom have pooled their expertise and resources in the present CIRID grant proposal. The present proposal has been significantly revised and has been prepared as a program project grant and includes five interrelated, interdependent research projects. Four of the project (1-4) interact around a central unifying theme of maturational immunologic processes in the developing host and their role in antimicrobial host defense. The broad hypothesis to be examined is that deficiency or impairment in development in any of a number of nonspecific and specific immunologic parameters can lead to immunologic compromise and predispose the developing host to severe infection and disease. The projects range from studies of the development of phagocytic function in the neonate (Project 1), structural and functional studies of the third component of complement (Project 2), developmental studies of the secretory IgA system (Project 3), studies of the developing immune system on responses to viral and myelin antigens (Project 4); a fifth project community outreach technology transfer and education includes a pediatric asthma patient education project utilizing self-management techniques.