IL-2-anti-IL-2 complexes in immunity to blood stage malaria infection and prevention of cerebral immunopathology

IL-2-抗IL-2复合物对血期疟疾感染的免疫和脑免疫病理学的预防

• 批准号: nhmrc : 613702
• 负责人: A/Pr Ashraful Haque
• 金额: $ 39.1万
• 依托单位: Queensland Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/il-2-anti-cerebral-immunopathology/82405
• 关键词: IL; anti; complexes; immunity; blood

Cerebral malaria is a severe complication of malaria infection, which accounts for a large proportion of malaria-related deaths each year. There is no vaccine against malaria licensed for use in humans. Trial vaccines have been shown to protect poorly against cerebral malaria, and have on occasion, increased the its incidence amongst experimental animals. We aim to develop a safe malaria vaccine that controls malaria parasite numbers in the body, and also prevents cerebral malaria.

脑型疟疾是疟疾感染的一种严重并发症，每年占疟疾相关死亡的很大比例。目前还没有获得许可用于人类的疟疾疫苗。试验疫苗已被证明对脑型疟疾的保护效果不佳，有时会增加实验动物的发病率。我们的目标是开发一种安全的疟疾疫苗，控制体内疟疾寄生虫的数量，并预防脑型疟疾。