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INTERDISCIPLINARY RESEARCH--IMMUNOLOGIC DISEASE

跨学科研究--免疫疾病

基本信息

批准号：
3105099
负责人：
JOSEPH Alphonso BELLANTI
金额：
$ 65.42万
依托单位：
GEORGETOWN UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1988
资助国家：
美国
起止时间：
1988-09-01 至 1994-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/3105099
关键词：
growth /development immunity immunopathology

项目摘要

The proposed Center Grant is a request for continued CIRID funding of an ongoing Center for Interdisciplinary Studies of Immunology at Georgetown. The Center exists as a functionally recognized unit of the University and has integrated programs in research, education and patient care, as well as in community, outreach, technology transfer and education. The overall proposed program project consists of senior investigators representing basic science and clinical disciplines (pediatrics, medicine, neurology, biochemistry, microbiology, biostatistics, and community medicine) all of whom have pooled their expertise and resources in the present CIRID grant proposal. The present proposal has been significantly revised and has been prepared as a program project grant and includes five interrelated, interdependent research projects. Four of the project (1-4) interact around a central unifying theme of maturational immunologic processes in the developing host and their role in antimicrobial host defense. The broad hypothesis to be examined is that deficiency or impairment in development in any of a number of nonspecific and specific immunologic parameters can lead to immunologic compromise and predispose the developing host to severe infection and disease. The projects range from studies of the development of phagocytic function in the neonate (Project 1), structural and functional studies of the third component of complement (Project 2), developmental studies of the secretory IgA system (Project 3), studies of the developing immune system on responses to viral and myelin antigens (Project 4); a fifth project community outreach technology transfer and education includes a pediatric asthma patient education project utilizing self-management techniques.

拟议的中心赠款是对CIRID继续资助的请求免疫学跨学科研究中心在乔治城。该中心作为一个职能得到承认的单位存在该大学，并在研究，教育和病人护理，以及社区，外展，技术转让和教育。总体方案建议该项目由代表基础科学的高级研究人员组成和临床学科（儿科，内科，神经病学，生物化学、微生物学、生物统计学和社区医学）他们都汇集了他们的专业知识和资源，目前CIRID赠款提案。目前的建议是经过重大修订，并已准备作为一个方案项目资助，包括五个相互关联，相互依存的研究项目四个项目（1 - 4）围绕一个中心互动成熟免疫过程的统一主题，发展中的主机和他们的抗菌主机防御的作用。的一个有待检验的广泛假设是，在发展中的任何一个数量的非特异性和特异性免疫学参数可导致免疫学损害，使发育中的宿主易于受到严重的感染和疾病。这些项目的范围从研究吞噬细胞的发展，新生儿的功能（项目1），结构和功能补体第三成分的研究（项目2），分泌型IgA系统的发育研究（项目3），研究发育中的免疫系统对病毒和髓鞘抗原（项目4）;第五个项目社区外展技术转让和教育包括儿科哮喘利用自我管理技术的病人教育项目。