INTERDISCIPLINARY RESEARCH--IMMUNOLOGIC DISEASE

跨学科研究--免疫疾病

• 批准号: 3105097
• 负责人: JOSEPH Alphonso BELLANTI
• 金额: $ 46.17万
• 依托单位: GEORGETOWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-09-01 至 1993-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3105097
• 关键词: growth /development; immunity; immunopathology

The proposed Center Grant is a request for continued CIRID funding of an ongoing Center for Interdisciplinary Studies of Immunology at Georgetown. The Center exists as a functionally recognized unit of the University and has integrated programs in research, education and patient care, as well as in community, outreach, technology transfer and education. The overall proposed program project consists of senior investigators representing basic science and clinical disciplines (pediatrics, medicine, neurology, biochemistry, microbiology, biostatistics, and community medicine) all of whom have pooled their expertise and resources in the present CIRID grant proposal. The present proposal has been significantly revised and has been prepared as a program project grant and includes five interrelated, interdependent research projects. Four of the project (1-4) interact around a central unifying theme of maturational immunologic processes in the developing host and their role in antimicrobial host defense. The broad hypothesis to be examined is that deficiency or impairment in development in any of a number of nonspecific and specific immunologic parameters can lead to immunologic compromise and predispose the developing host to severe infection and disease. The projects range from studies of the development of phagocytic function in the neonate (Project 1), structural and functional studies of the third component of complement (Project 2), developmental studies of the secretory IgA system (Project 3), studies of the developing immune system on responses to viral and myelin antigens (Project 4); a fifth project community outreach technology transfer and education includes a pediatric asthma patient education project utilizing self-management techniques.

拟议的中心拨款是对 CIRID 持续资助的请求 正在进行的免疫学跨学科研究中心 在乔治城。 该中心作为功能上得到认可的单位而存在 大学的综合课程， 教育和患者护理，以及社区、外展、 技术转让和教育。 总体拟议方案 项目由代表基础科学的高级研究人员组成 和临床学科（儿科、医学、神经病学、 生物化学、微生物学、生物统计学和社区医学） 所有这些人都集中了自己的专业知识和资源 提出 CIRID 拨款提案。 目前的提案已 进行了重大修改并已作为计划项目进行准备 拨款并包括五项相互关联、相互依赖的研究 项目。 四个项目（1-4）围绕一个中心相互作用 成熟免疫过程的统一主题 发育中的宿主及其在抗菌宿主防御中的作用。 这 要检验的广泛假设是缺陷或损害 正在开发中的任何非特定和特定的 免疫学参数可能导致免疫学损害 使发育中的宿主容易遭受严重感染和疾病。 这些项目包括吞噬细胞发育的研究 新生儿的功能（项目 1），结构和功能 补体第三成分的研究（项目2）， 分泌型 IgA 系统的发育研究（项目 3）， 研究发育中的免疫系统对病毒和病毒的反应 髓磷脂抗原（项目 4）；第五个项目社区外展 技术转让和教育包括小儿哮喘 利用自我管理技术的患者教育项目。