Cytosine methylation predicts diabetic nephropathy progression

胞嘧啶甲基化预测糖尿病肾病进展

• 批准号: nhmrc : 2003401
• 金额: $ 72.38万
• 依托单位国家: 澳大利亚
• 项目类别: Ideas Grants
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/cytosine-methylation-predicts-nephropathy-progression/1780134
• 关键词: Cytosine; methylation; predicts; diabetic; nephropathy

Over 2 million Australians have diabetes and up to one in three adults will develop diabetes or pre-diabetes in their lifetime with the associated burden of complications. It is not simply genetics, as the genetic variability cannot explain why some individuals and indeed some families appear to be programmed to have an inordinate burden of complications. Over the last decade we have developed state of the art technologies to characterise epigenetic changes in human clinical cohorts.

超过200万澳大利亚人患有糖尿病，多达三分之一的成年人将在其一生中患上糖尿病或糖尿病前期，并伴随并发症的相关负担。这不仅仅是遗传学的问题，因为遗传变异性不能解释为什么有些个体甚至有些家庭似乎被编程为具有过度的并发症负担。在过去的十年中，我们已经开发出最先进的技术来监测人类临床队列中的表观遗传变化。