CELLULAR ION HOMEOSTASIS IN HYPERTENSION
CELLULAR ION HOMEOSTASIS IN HYPERTENSION
批准号:
3855121
负责人:
ROGER RICK
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
中文摘要
这个项目的目标是确定一种可能的
肾小管转运异常(肾脏固有的或
对调节性体液制剂的异常反应),导致
实验性高血压动物模型中不适当的钠滞留
高血压。这个项目背后的假设是,假设
膜缺陷表现为细胞内稳态的紊乱。
因此,应该可以被细胞内检测到
浓度测量。用于电解液的测定
在单个肾小管细胞,甚至亚细胞结构中的浓度,
我们将采用电子探针分析技术。这些分析
将在冷冻干燥的薄切片上进行,
电击冷冻的组织样本。最初,只有短暂的、未灌流的孤立
取肾单位段作为标本。稍后,我们将尝试
获得较长的节段,在冷冻之前可以在In
体外条件。为此,我们将开发一种技术,
允许在灌流时快速冻结小管。使用这些
方法,我们将首先研究细胞电解质的组成。
从两种不同模型获得的不同管段
基因固定的高血压。第二,我们将考察高利率的影响
以及在不同动物模型中正常的含NaCl日粮。第三,我们
将调查异常反应的可能性
肾小管钠转运的调节器。这个项目将密切关注
与项目2、3、4和8的运输研究相结合。
英文摘要
The goal of this project is to identify the cellular basis of a likely
tubular transport abnormality (either intrinsic to the kidney or an
abnormal response to regulatory humoral agents) which leads to
inappropriate sodium retention in experimental animal models of
hypertension. The assumption underlying this project is that the presumed
membrane defect is expressed in a disturbance of the cellular homeostasis
of renal cells and, therefore, should be detectable by intracellular
concentration measurements. For determination of electrolyte
concentrations in individual tubular cells, or even subcellular structures,
we will employ the technique of electron microprobe analysis. The analyses
will be performed on thin frozen-dried cryosections obtained from fresh,
shock-frozen tissue samples. Initially, only short, non-perfused isolated
nephron segments will be used as specimen. Later, we will attempt to
obtain longer segments which can be perfused prior to freezing under in
vitro conditions. For this purpose, we will develop a technique which
allows rapid freezing of the tubules while being perfused. Using these
methods, we will first study the cellular electrolytes composition of
different tubular segments obtained from two different models of
genetically fixed hypertension. Second, we will examine the effect of high
and normal NaC1-containing diets in different animal models. Third, we
will investigate the possibility of an abnormal responsiveness to
modulators of tubular Na transport. This project will be closely
integrated with the transport studies of Projects 2, 3, 4 and 8.
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会议论文
ELECTRON MICROPROBE ANALYSIS OF EPITHELIAL NA TRANSPORT
-
批准号:3233980
-
项目类别:
-
资助金额:$14.88万
-
财政年份:1986
-
负责人:ROGER RICK
-
依托单位:
ELECTRON MICROPROBE ANALYSIS OF EPITHELIAL NA TRANSPORT
-
批准号:3233979
-
项目类别:
-
资助金额:$14.65万
-
财政年份:1986
-
负责人:ROGER RICK
-
依托单位:
ELECTRON MICROPROBE ANALYSIS OF EPITHELIAL NA TRANSPORT
-
批准号:3233982
-
项目类别:
-
资助金额:$16.29万
-
财政年份:1986
-
负责人:ROGER RICK
-
依托单位:
ELECTRON MICROPROBE ANALYSIS OF EPITHELIAL NA TRANSPORT
-
批准号:3233981
-
项目类别:
-
资助金额:$15.23万
-
财政年份:1986
-
负责人:ROGER RICK
-
依托单位:
ELECTRON MICROPROBE ANALYSIS OF EPITHELIAL NA TRANSPORT
-
批准号:3233978
-
项目类别:
-
资助金额:$15.47万
-
财政年份:1986
-
负责人:ROGER RICK
-
依托单位:
MICRODROPLET ION ASSAY BY ELECTRON MICROPROBE--CORE
-
批准号:3897619
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:ROGER RICK
-
依托单位:
MICRODROPLET ION ASSAY BY ELECTRON MICROPROBE--CORE
-
批准号:3876198
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:ROGER RICK
-
依托单位:
MICRODROPLET ION ASSAY BY ELECTRON MICROPROBE--CORE
-
批准号:3941031
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:ROGER RICK
-
依托单位:
MICRODROPLET ION ASSAY BY ELECTRON MICROPROBE--CORE
-
批准号:3918156
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:ROGER RICK
-
依托单位:
MICRODROPLET ION ASSAY BY ELECTRON MICROPROBE--CORE
-
批准号:3855127
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:ROGER RICK
-
依托单位:
CELLULAR ION HOMEOSTASIS IN HYPERTENSION
-
批准号:3918150
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:ROGER RICK
-
依托单位:
CELLULAR ION HOMEOSTASIS IN HYPERTENSION
-
批准号:3941025
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:ROGER RICK
-
依托单位:
CELLULAR ION HOMEOSTASIS IN HYPERTENSION
-
批准号:3897613
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:ROGER RICK
-
依托单位:
CELLULAR ION HOMEOSTASIS IN HYPERTENSION
-
批准号:3876192
-
项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:ROGER RICK
-
依托单位:
海外基金