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PERIODONTAL DISEASE RESEARCH CENTER

牙周疾病研究中心

基本信息

批准号：
2129538
负责人：
WILLIAM B CLARK
金额：
$ 75.92万
依托单位：
UNIVERSITY OF FLORIDA
依托单位国家：
美国
项目类别：
财政年份：
1985
资助国家：
美国
起止时间：
1985-09-01 至 1995-04-17
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/2129538
关键词：
dental disorder diagnosis human subject oral bacteria periodontitis periodontium disorder

项目摘要

The major objectives of this Center are to develop modalities for diagnosis, treatment, and prevention of periodontal diseases. A series of related clinical, microbiological, and immunological studies have been designed to address these objectives. The clinical component is designed to detect early disease activity utilizing highly sensitive detection methods such as an electronic constant-force probe which has been shown to be highly sensitive and reproducible. Microbiologic and immunologic studies are designed to investigate the microbial etiologies of refractory and suppurative periodontal diseases and to define the interrelationship between specific microorganisms and the host's immune response. Clinical measurements will be performed to verify that individual sites are in an actively progressing state of disease prior to therapy and in a state of remission after therapy. The composition of the microbiota and the immune response will be examined longitudinally in each patient to determine the overall effects of different therapeutic regimens. Determination of the effect of different periodontal therapies on the clinical response the host's microbiota, and the immune response, should lead to more rational approaches in the treatment of these diseases. By thoroughly investigating the multiplicity of interrelated factors associated with the periodontal disease process, it hoped that bases for rational prevention and therapy will be established. The objective of the squirrel monkey (Saimiri sciureus) study is to develop an in vivo model for colonization with suspected periodontal pathogens (e.g., B. gingivalis, H. actinomycetemcomitans) and then to examine the effects of immunization on colonization. The specific aims are: (1) establish an association between one or more subgingival bacteria (e.g., B. gingivalis) and disease; (2) define the relationship of immunity to suspected periodontal pathogens; (3) investigate the mechanisms of infection and oral colonization of monkeys with pathogens; (4) identify and characterize the antigens from pathogenic bacteria against which normally infected and immunized monkeys make antibody; and (5) test the effect of immunization on colonization of subgingival plaque with pathogenic bacteria. From these studies, the microbiota involved in disease as well as the humoral immune response to these bacteria will be defined. A model of colonization of subgingival plaque by identified pathogens will be developed. This model will then be used to study the potential of the humoral immune response to modulate the oral colonization by suspected pathogens. Information of this type will provide valuable knowledge to our understanding of periodontal diseases and possibly provide a basis for a rational approach to immunologic prevention of periodontal diseases.

该中心的主要目标是开发用于牙周病的诊断、治疗和预防。一个一系列相关的临床、微生物学和免疫学研究的目的就是为了实现这些目标。这个临床组件旨在检测早期疾病活动利用高度灵敏的检测方法，如电子恒力探头，已被证明是高度敏感的而且是可复制的。微生物学和免疫学研究旨在调查难治性和非霍奇金淋巴瘤的微生物病因化脓性牙周病和定义特定微生物与寄主之间的相互关系免疫反应。将进行临床测量以验证个别站点正处于积极发展的状态治疗前的疾病和治疗后的缓解状态。微生物区系的组成和免疫反应将是对每个患者进行纵向检查，以确定总体不同治疗方案的效果。确定了不同牙周治疗方法对临床疗效的影响宿主的微生物区系和免疫反应应该会导致更多治疗这些疾病的合理方法。通过深入调查相关因素的多样性与牙周病的过程有关，它希望为合理防治奠定基础。松鼠猴(Saimiri Scureus)研究的目的是建立疑似猪瘟的体内定植模型牙周病原菌(牙周炎、牙周炎、牙周炎)。伴生放线菌)，然后考察关于殖民的免疫。具体目标是：(1) 在一种或多种牙龈下细菌之间建立联系 (2)定义了对可疑牙周病原体的免疫力；(3)调查猴的感染和口腔定植机制的研究病原体；(4)鉴定和表征来自正常感染和免疫的病原菌猴子产生抗体；以及(5)检测免疫效果龈下菌斑的病原菌定植。从这些研究中，涉及疾病的微生物区系以及对这些细菌的体液免疫反应将被定义。一个已鉴定病原菌在龈下菌斑定植的模型将会被开发出来。然后这个模型将被用来研究体液免疫反应对口腔的调节作用疑似病原体的殖民。此类型的信息将为我们了解牙周组织提供有价值的知识疾病，并可能为采取合理的方法牙周病的免疫预防。