PERIODONTAL DISEASE RESEARCH CENTER

牙周疾病研究中心

• 批准号: 3105649
• 负责人: WILLIAM B CLARK
• 金额: $ 56.63万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-09-01 至 1988-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3105649
• 关键词: dental disorder diagnosis; oral bacteria; periodontium disorder

The major objectives of this Center are to develop modalities for diagnosis, treatment, and prevention of periodontal diseases. A series of related clinical, microbiological, and immunological studies have been designed to address these objectives. The clinical component is designed to detect early disease activity utilizing highly sensitive detection methods such as an electronic constant-force probe which has been shown to be highly sensitive and reproducible. Microbiologic and immunologic studies are designed to investigate the microbial etiologies of refractory and suppurative periodontal diseases and to define the interrelationship between specific microorganisms and the host's immune response. Clinical measurements will be performed to verify that individual sites are in an actively progressing state of disease prior to therapy and in a state of remission after therapy. The composition of the microbiota and the immune response will be examined longitudinally in each patient to determine the overall effects of different therapeutic regimens. Determination of the effect of different periodontal therapies on the clinical response, the host's microbiota, and the immune response, should lead to more rational approaches in the treatment of these diseases. By thoroughly investigating the multiplicity of interrelated factors associated with the periodontal disease process, it is hoped that bases for rational prevention and therapy will be established. The objective of the squirrel monkey (Saimiri sciureus) study is to develop an in vivo model for colonization with suspected periodontal pathogens (e.g., B. gingivalis, H. actinomycetemcomitans) and then to examine the effects of immunization on colonization. The specific aims are: (1) establish an association between one or more subgingival bacteria (e.g., B. gingivalis) and disease; (2) define the relationship of immunity to suspected periodontal pathogens; (3) investigate the mechanisms of infection and oral colonization of monkeys with pathogens; (4) identify and characterize the antigens from pathogenic bacteria against which normally infected and immunized monkeys make antibody; and (5) test the effect of immunization on colonization of subgingival plaque with pathogenic bacteria. From the studies, the microbiota involved in disease as well as the humoral immune response to these bacteria will be defined. A model of colonization of subgingival plaque by identified pathogens will be developed. This model will then be used to study the potential of the humoral immune response to modulate the oral colonization by suspected pathogens. Information of this type will provide valuable knowledge to our understanding of periodontal diseases and possibly provide a basis for a rational approach to immunologic prevention of periodontal diseases.

该中心的主要目标是开发模式 牙周病的诊断、治疗和预防。 一个 系列相关的临床、微生物学和免疫学 研究旨在实现这些目标。 这 临床部分旨在检测早期疾病活动 利用高度灵敏的检测方法，例如电子 恒力探头已被证明具有高灵敏度 并且可重复。 微生物学和免疫学研究是 旨在研究难治性和难治性的微生物病因 化脓性牙周病并定义 特定微生物与宿主之间的相互关系 免疫反应。 将进行临床测量 验证各个站点是否处于积极进展状态 治疗前疾病和治疗后疾病缓解状态。 微生物群的组成和免疫反应将 对每位患者进行纵向检查以确定 不同治疗方案的总体效果。 决心 不同牙周治疗方法对临床的影响 反应、宿主的微生物群和免疫反应，应该 导致治疗这些问题时采取更合理的方法 疾病。 通过彻底调查多样性 与牙周病相关的相关因素 过程中，希望能够合理预防和治疗 将成立。 松鼠猴（Saimiri sciureus）研究的目的是 开发疑似定植体内模型 牙周病原体（例如牙龈芽孢杆菌、幽门螺杆菌） actinomycetemcomitans），然后检查的影响 殖民化免疫。 具体目标是：（1） 建立一种或多种龈下细菌之间的关联 （例如牙龈芽孢杆菌）和疾病； (2) 定义关系 对可疑牙周病原体的免疫力； (3)调查 猴子的感染和口腔定植机制 病原体； (4) 鉴定和表征抗原 通常感染的致病菌和 免疫猴子产生抗体； (5) 测试效果 对龈下菌斑定植进行免疫 致病菌。 研究表明，与疾病相关的微生物群以及 对这些细菌的体液免疫反应将被定义。 一个 龈下菌斑定植模型 病原体将会产生。 然后该模型将用于 研究体液免疫反应调节的潜力 可疑病原体的口腔定植。 这个的信息 类型将为我们的理解提供有价值的知识 牙周病的防治并可能为合理治疗牙周病提供依据 牙周病的免疫学预防方法。