BOSTON UNIVERSITY APHASIA RESEARCH CENTER

波士顿大学失语症研究中心

• 批准号: 3105494
• 负责人: HAROLD GOODGLASS
• 金额: $ 103.36万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 1977
• 资助国家: 美国
• 起止时间: 1977-12-01 至 1995-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3105494
• 关键词: aphasia; chronic brain damage; communication disorders; language disorders

This is a continuation of a program for the study of clinical, neurolinguistic and neuroanatomic aspects of aphasia. The long term objectives are to advance the understanding of the mechanisms of normal language and their neural basis so as to develop a coherent view of how the symptomatology of aphasia relates to the injury of particular brain structures and consequent modification of linguistic and cognitive capacities. A concurrent goal is apply developing theoretical insights to a rationally based diagnostic assessment and treatment of aphasia. Specific goals in the proposed project period and methods of accomplishing them are: 1. To investigate disorders of sentence comprehension and sentence production in terms of the explanatory power of specific cognitive and linguistic principles. 2. To study word production and word comprehension with techniques that probe the unfolding of these processes and their breakdown in real time. 3. To study the long term recovery of aphasics in terms of changes in neurological, linguistic, cognitive and social function. 4. To study the basis for perseveration in aphasia, and the basis for its improvement with therapy. 5. To investigate the neurochemical basis of nonfluency in aphasia and its pharmacological treatment, using bromocriptine. 6. To investigate the role of the right hemisphere in mediating language recovery in aphasia. 7. To study the CT and MRI scan lesion correlates of long term recovery in particular language skills and to compare the effectiveness of these two imaging techniques.

这是一个临床研究项目的延续， 失语症的神经语言学和神经解剖学方面。 长期 目标是促进正常的机制的理解， 语言和他们的神经基础，以便发展一个连贯的观点， 失语症的病理学与特定的脑损伤有关 语言和认知的结构和随之而来的修改 能力。 一个共同的目标是将发展理论见解应用于 失语症的合理诊断评估和治疗。 项目期间的具体目标和实现方法 他们是： 1.探讨句子理解障碍和句子 生产的解释力方面的具体认知和 语言原则。 2.学习单词产生和单词理解的技巧， 探索这些过程的展开和它们在真实的时间中的崩溃。 3.研究失语症患者长期康复后， 神经、语言、认知和社会功能。 4.研究失语症持续的基础， 通过治疗改善。 5.探讨失语症患者非流利性的神经化学基础， 药物治疗，使用溴隐亭。 6.探讨右半球在语言中介中的作用 失语症的康复 7.目的：研究脑梗死患者长期康复的CT和MRI扫描病变相关性， 特别是语言技能，并比较这两个有效性 成像技术。