Recovering from chronic brain damage by Transcranial Direct Current Stimulation

通过经颅直流电刺激从慢性脑损伤中恢复

基本信息

项目摘要

DESCRIPTION (provided by applicant): In the last three years, the biomedical community has seen an explosion in the use of invasive and non- invasive brain neuromodulation methods to increase recovery of function after localized brain damage. Such techniques operate on the principle that neural plasticity -the ability of a damaged brain to compensate for behavioral deficits- can be boosted and guided by techniques able to "sculpt" the functional patterns of excitability in spared or affected neural networks. Among the best known, Deep Brain Stimulation (DBS), Epidural Brain Stimulation (EDBS), and more recently Transcranial Magnetic Stimulation (TMS) have stood out in providing very encouraging preliminary results in chronic stroke patients. The mechanisms, real therapeutic potential, side effects and spectrum of neural "costs" of these stimulation methods remain to be fully explored in animal models and clinical applications. Nevertheless, they have provided behavioral neurology and psychiatry with new hopes of treatment in medical fields and conditions for which diagnosis was in many cases the ultimate and final step. In this emerging scenario, transcranial Direct Current Stimulation (tDCS), the effects of which were first studied during the early 1960s, has been recently "re-discovered" and is being re-evaluated for clinical and therapeutic use. Transcranial DC Stimulation provides a non-invasive, easy to apply and low cost method to stimulate or polarize brain tissue and has considerable potential to produce guided changes in neural activity and result in significant patterns of recovery after brain damage. Notwithstanding, not much is yet known on its ability to induce long lasting effects on intact and spared neural networks and particularly how such modulation can explain at the system's level the achievement of behavioral recovery. In order to fully assess its therapeutic potential and study its spatial network specificity we propose to test its effects in a well- studied feline model of unilateral parietal damage resulting into visual-spatial neglect. We plan on achieving long-lasting improvements in degraded visuo-spatial detection-localization abilities by means of two strategies both aimed at facilitating plastic take over of lost functions by spared cortical or subcortical regions. More importantly, by means of whole-brain metabolic glucose labeling techniques, we will try to develop a detailed understanding of the nature and extent of the mechanisms underlying such recovery, so that it can be optimally applied. PUBLIC HEALTH RELEVANCE: We will test the use of transcranial Direct Current Stimulation (tDCS) for improving function after chronic cerebral damage. We will study its underlying mechanisms of action and derive conclusions for future human therapeutic applications in clinical settings.
描述(由申请人提供):在过去三年中,生物医学界已经看到使用侵入性和非侵入性脑神经调节方法来增加局部脑损伤后的功能恢复的爆炸式增长。这些技术的原理是,神经可塑性--受损大脑补偿行为缺陷的能力--可以通过能够“雕刻”幸存或受影响神经网络的兴奋性功能模式的技术来增强和指导。其中最著名的,脑深部电刺激(DBS),硬膜外脑刺激(EDBS),以及最近的经颅磁刺激(TMS)在慢性中风患者中提供了非常令人鼓舞的初步结果。这些刺激方法的机制、真实的治疗潜力、副作用和神经“代价”谱仍有待在动物模型和临床应用中充分探索。尽管如此,他们为行为神经病学和精神病学提供了新的希望,在医学领域和条件下,诊断在许多情况下是最终的和最后的步骤。在这种新兴的情况下,经颅直流电刺激(tDCS),其效果在20世纪60年代初首次研究,最近已被“重新发现”,并正在重新评估临床和治疗用途。经颅直流电刺激提供了一种非侵入性、易于应用和低成本的方法来刺激或刺激脑组织,并且具有相当大的潜力来产生神经活动的引导变化,并导致脑损伤后的显著恢复模式。尽管如此,还没有太多的人知道它的能力,以诱导对完整的和备用的神经网络的长期持久的影响,特别是如何这种调制可以解释在系统的水平上的行为恢复的实现。为了充分评估其治疗潜力并研究其空间网络特异性,我们建议在一个研究充分的单侧顶叶损伤导致视觉空间忽视的猫模型中测试其效果。我们计划通过两种策略来实现退化的视觉空间检测定位能力的长期改善,这两种策略都旨在促进备用皮层或皮层下区域对失去的功能的塑性接管。更重要的是,通过全脑代谢葡萄糖标记技术,我们将试图详细了解这种恢复的机制的性质和程度,以便它可以最佳地应用。公共卫生相关性:我们将测试经颅直流电刺激(tDCS)用于改善慢性脑损伤后的功能。我们将研究其潜在的作用机制,并得出结论,为未来的人类临床治疗应用。

项目成果

期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Game theoretical mapping of white matter contributions to visuospatial attention in stroke patients with hemineglect.
偏侧忽视中风患者白质对视觉空间注意力贡献的博弈论映射。
  • DOI:
    10.1002/hbm.24987
  • 发表时间:
    2020
  • 期刊:
  • 影响因子:
    4.8
  • 作者:
    Toba,MonicaN;Zavaglia,Melissa;Malherbe,Caroline;Moreau,Tristan;Rastelli,Federica;Kaglik,Anna;Valabrègue,Romain;Pradat-Diehl,Pascale;Hilgetag,ClausC;Valero-Cabré,Antoni
  • 通讯作者:
    Valero-Cabré,Antoni
[Transcranial magnetic stimulation (TMS) in basic and clinical neuroscience research].
  • DOI:
    10.1016/j.neurol.2010.10.013
  • 发表时间:
    2011-04
  • 期刊:
  • 影响因子:
    3
  • 作者:
    Valero-Cabré A;Pascual-Leone A;Coubard OA
  • 通讯作者:
    Coubard OA
Multiple sessions of transcranial direct current stimulation to the intact hemisphere improves visual function after unilateral ablation of visual cortex.
单侧视觉皮层消融后,对完整半球进行多次经颅直流电刺激可改善视觉功能。
  • DOI:
    10.1111/ejn.12373
  • 发表时间:
    2013
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Rushmore,RJ;DeSimone,C;Valero-Cabré,A
  • 通讯作者:
    Valero-Cabré,A
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RICHARD Jarrett RUSHMORE其他文献

RICHARD Jarrett RUSHMORE的其他文献

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{{ truncateString('RICHARD Jarrett RUSHMORE', 18)}}的其他基金

Using transcranial brain stimulation to prevent cortical spreading depression
使用经颅脑刺激预防皮质扩散性抑郁
  • 批准号:
    8823034
  • 财政年份:
    2014
  • 资助金额:
    $ 20.31万
  • 项目类别:
Parietal and Temporal Circuits in Cognition
认知中的顶叶和颞叶回路
  • 批准号:
    6622312
  • 财政年份:
    2002
  • 资助金额:
    $ 20.31万
  • 项目类别:
Parietal and Temporal Circuits in Cognition
认知中的顶叶和颞叶回路
  • 批准号:
    6445153
  • 财政年份:
    2002
  • 资助金额:
    $ 20.31万
  • 项目类别:

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