MUSCLE METABOLISM AND MUSCLE FATIGUE IN FIBROMYALGIA SYNDROME

纤维肌痛综合征中的肌肉代谢和肌肉疲劳

• 批准号: 3804278
• 负责人: ROBERT SIMMS
• 金额: --
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3804278
• 关键词: electromyography; fatigue; fibromyalgia; muscle metabolism; noninvasive diagnosis; nuclear magnetic resonance spectroscopy

Fibromyalgia (FMS) is a common, poorly understood rheumatic disorder characterized by symptoms of chronic fatigue and musculoskeletal pain. Recent studies have suggested that muscle metabolism may be abnormal in FMS, although most of these studies to date have not adequately controlled the level of fitness. This study proposes to examine the hypothesis that abnormal muscle fatigue and metabolism are present in FMS, by utilizing a unique combination of two highly sensitive techniques: surface electromyography (EMG) and 31P-Nuclear Magnetic Resonance (NMR) spectroscopy. These two techniques will be used to simultaneously determine the precise electrophysiologic and metabolic characteristics of muscle in patients with FMS. The surface EMG data will provide an objective index that may have clinical applicability as an easily administered, non-invasive assessment procedure for muscle dysfunction associated with FMS. The proven capability and more direct methodology of NMR-spectroscopy will identify the phosphate components of muscle energetics and will validate the EMG methodology. Controls will be carefully matched for age, gender and level of activity. In addition, the level of aerobic fitness will be determined in both patients and control subjects. The electrophysiologic and high energy phosphate metabolite changes associated with muscle fatigue will be compared in patient and control populations at each muscle site. It is anticipated that these data will determine whether the metabolic and electrophysiologic properties of muscles in patients with FMS are abnormal.

纤维肌痛 (FMS) 是一种常见的、人们知之甚少的风湿性疾病 其特征是慢性疲劳和肌肉骨骼疼痛的症状。 最近的研究表明，肌肉代谢可能异常 FMS，尽管迄今为止大多数研究都没有充分控制 健身水平。 本研究旨在检验以下假设： FMS 中存在异常的肌肉疲劳和代谢，通过利用 两种高度敏感技术的独特组合：表面 肌电图 (EMG) 和 31P-核磁共振 (NMR) 光谱学。 这两种技术将同时用于 确定精确的电生理和代谢特征 FMS 患者的肌肉。 表面肌电图数据将提供 可能具有临床适用性的客观指标 针对肌肉功能障碍的管理、非侵入性评估程序 与 FMS 相关。 经过验证的能力和更直接的方法 核磁共振波谱学将鉴定肌肉的磷酸盐成分 能量学并将验证肌电图方法。 控制措施将是 仔细匹配年龄、性别和活动水平。 此外， 将确定患者和对照组的有氧健身水平 科目。 电生理和高能磷酸代谢物 将比较患者和患者与肌肉疲劳相关的变化 控制每个肌肉部位的数量。 预计这些数据 将决定是否代谢和电生理特性 FMS 患者的肌肉异常。