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The role of the KRAB zinc-finger protein ZFP57 in the maintenance of the methylation programme in mouse development

The role of the KRAB zinc-finger protein ZFP57 in the maintenance of the methylation programme in mouse development
KRAB 锌指蛋白 ZFP57 在维持小鼠发育中甲基化程序中的作用
批准号:
BB/G020930/1
负责人:
Anne Ferguson-Smith
金额:
$46.68万
依托单位:
依托单位国家:
英国
项目类别:
Research Grant
财政年份:
2009
资助国家:
英国
项目状态:
已结题
起止时间:
2009 至 --

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中文摘要
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英文摘要
DNA is packaged inside our cells into bundles called chromosomes. Chromosome packaging is a highly regulated process that ensures that the correct cell makes the correct genes available for proper regulation specific to that cell. We are interested in the factors that regulate DNA packaging into chromosomes and in particular we are interested in the changes that happen to chromosome packaging as stem cells develop into body cells. We have made a mutant where key factors required for proper gene regulation are not placed on the DNA and the chromosomes. These experiments are designed to learn more about this key factor and how it influences the chromosomes in early development.
期刊论文(10)
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会议论文
DOI: 10.1186/s13100-021-00235-1
发表时间: 2021-02-21
期刊: Mobile DNA
影响因子: 4.9
作者: [Elmer JL, Hay AD, Kessler NJ, Bertozzi TM, Ainscough EAC, Ferguson-Smith AC]
通讯作者: Ferguson-Smith AC
DOI: 10.1038/s41588-021-00898-9
发表时间: 2021-08
期刊: Nature genetics
影响因子: 30.8
作者: [Bertozzi TM, Becker JL, Blake GET, Bansal A, Nguyen DK, Fernandez-Twinn DS, Ozanne SE, Bartolomei MS, Simmons RA, Watson ED, Ferguson-Smith AC]
通讯作者: Ferguson-Smith AC
DOI: 10.1073/pnas.2017053117
发表时间: 2020-12-08
期刊: Proceedings of the National Academy of Sciences of the United States of America
影响因子: 11.1
作者: [Bertozzi TM, Elmer JL, Macfarlan TS, Ferguson-Smith AC]
通讯作者: Ferguson-Smith AC
DOI: 10.7554/elife.65233
发表时间: 2021-03-23
期刊: eLife
影响因子: 7.7
作者: [Bertozzi TM, Takahashi N, Hanin G, Kazachenka A, Ferguson-Smith AC]
通讯作者: Ferguson-Smith AC
6
    Genomic imprinting and the epigenetic control of genome function: regulation, redundancy and resilience
    • 批准号:
      MR/X018407/1
    • 项目类别:
      Research Grant
    • 资助金额:
      $351.13万
    • 财政年份:
      2023
    • 负责人:
      Anne Ferguson-Smith
    • 依托单位:
    BBSRC IAA University of Cambridge
    • 批准号:
      BB/X511092/1
    • 项目类别:
      Research Grant
    • 资助金额:
      $50.33万
    • 财政年份:
      2022
    • 负责人:
      Anne Ferguson-Smith
    • 依托单位:
    Landscape Regeneration Solutions to the Interlinked Extinction and Climate Crises that support Sustainable Development
    • 批准号:
      NE/W00495X/1
    • 项目类别:
      Research Grant
    • 资助金额:
      $1301.45万
    • 财政年份:
      2022
    • 负责人:
      Anne Ferguson-Smith
    • 依托单位:
    University of Cambridge Impact Acceleration Account
    • 批准号:
      AH/X003558/1
    • 项目类别:
      Research Grant
    • 资助金额:
      $63.37万
    • 财政年份:
      2022
    • 负责人:
      Anne Ferguson-Smith
    • 依托单位:
    国内基金
    海外基金
    KRAB锌指蛋白调控tRNA引物结合位点抑制逆转录病毒元件的分子机制研究
    • 批准号:
      32070652
    • 项目类别:
      面上项目
    • 资助金额:
      58.0万元
    • 批准年份:
      2020
    • 负责人:
      杨鹏
    • 依托单位:
    KRAB型锌指蛋白ZNF599对细胞核形态的影响及其机制研究
    • 批准号:
      31701097
    • 项目类别:
      青年科学基金项目
    • 资助金额:
      24.0万元
    • 批准年份:
      2017
    • 负责人:
      刘楠
    • 依托单位:
    KRAB型锌指蛋白PITA和PISA与p53介导的细胞代谢调控关系研究
    KRAB型锌指蛋白ZNF75D在基因转录调控及肿瘤发生发展中的作用
    • 批准号:
      81372166
    • 项目类别:
      面上项目
    • 资助金额:
      75.0万元
    • 批准年份:
      2013
    • 负责人:
      易霞
    • 依托单位: