The role of the KRAB zinc-finger protein ZFP57 in the maintenance of the methylation programme in mouse development
The role of the KRAB zinc-finger protein ZFP57 in the maintenance of the methylation programme in mouse development
批准号:
BB/G020930/1
负责人:
Anne Ferguson-Smith
金额:
$46.68万
依托单位:
依托单位国家:
英国
项目类别:
Research Grant
财政年份:
2009
资助国家:
英国
项目状态:
已结题
起止时间:
2009 至 --
中文摘要
点击翻译按钮获取中文摘要
英文摘要
DNA is packaged inside our cells into bundles called chromosomes. Chromosome packaging is a highly regulated process that ensures that the correct cell makes the correct genes available for proper regulation specific to that cell. We are interested in the factors that regulate DNA packaging into chromosomes and in particular we are interested in the changes that happen to chromosome packaging as stem cells develop into body cells. We have made a mutant where key factors required for proper gene regulation are not placed on the DNA and the chromosomes. These experiments are designed to learn more about this key factor and how it influences the chromosomes in early development.
期刊论文(10)
专著(0)
科研奖励(0)
会议论文
登录
查看更多内容
DOI:
10.1186/s13100-021-00235-1
发表时间:
2021-02-21
期刊:
Mobile DNA
影响因子:
4.9
作者:
[Elmer JL, Hay AD, Kessler NJ, Bertozzi TM, Ainscough EAC, Ferguson-Smith AC]
通讯作者:
Ferguson-Smith AC
DOI:
10.1038/s41588-021-00898-9
发表时间:
2021-08
期刊:
Nature genetics
影响因子:
30.8
作者:
[Bertozzi TM, Becker JL, Blake GET, Bansal A, Nguyen DK, Fernandez-Twinn DS, Ozanne SE, Bartolomei MS, Simmons RA, Watson ED, Ferguson-Smith AC]
通讯作者:
Ferguson-Smith AC
DOI:
10.1073/pnas.2017053117
发表时间:
2020-12-08
期刊:
Proceedings of the National Academy of Sciences of the United States of America
影响因子:
11.1
作者:
[Bertozzi TM, Elmer JL, Macfarlan TS, Ferguson-Smith AC]
通讯作者:
Ferguson-Smith AC
DOI:
10.7554/elife.65233
发表时间:
2021-03-23
期刊:
eLife
影响因子:
7.7
作者:
[Bertozzi TM, Takahashi N, Hanin G, Kazachenka A, Ferguson-Smith AC]
通讯作者:
Ferguson-Smith AC
Metastable epialleles and their contribution to epigenetic inheritance in mammals
亚稳态表观等位基因及其对哺乳动物表观遗传的贡献
DOI:
10.17863/cam.42457
发表时间:
2020
期刊:
影响因子:
--
作者:
[Bertozzi T]
通讯作者:
Bertozzi T
共 6 条
Genomic imprinting and the epigenetic control of genome function: regulation, redundancy and resilience
-
批准号:MR/X018407/1
-
项目类别:Research Grant
-
资助金额:$351.13万
-
财政年份:2023
-
负责人:Anne Ferguson-Smith
-
依托单位:
BBSRC IAA University of Cambridge
-
批准号:BB/X511092/1
-
项目类别:Research Grant
-
资助金额:$50.33万
-
财政年份:2022
-
负责人:Anne Ferguson-Smith
-
依托单位:
Landscape Regeneration Solutions to the Interlinked Extinction and Climate Crises that support Sustainable Development
-
批准号:NE/W00495X/1
-
项目类别:Research Grant
-
资助金额:$1301.45万
-
财政年份:2022
-
负责人:Anne Ferguson-Smith
-
依托单位:
University of Cambridge Impact Acceleration Account
-
批准号:AH/X003558/1
-
项目类别:Research Grant
-
资助金额:$63.37万
-
财政年份:2022
-
负责人:Anne Ferguson-Smith
-
依托单位:
Cross-disciplinary research for Discovery Science
-
批准号:NE/X018202/1
-
项目类别:Research Grant
-
资助金额:$12.85万
-
财政年份:2022
-
负责人:Anne Ferguson-Smith
-
依托单位:
Genomic Imprinting and the regulation of postnatal nutritional resources via breastmilk
-
批准号:MR/W003783/1
-
项目类别:Research Grant
-
资助金额:$109.72万
-
财政年份:2021
-
负责人:Anne Ferguson-Smith
-
依托单位:
Mechanisms targeting epigenetic states in mammals
-
批准号:BB/R009996/1
-
项目类别:Research Grant
-
资助金额:$66.57万
-
财政年份:2018
-
负责人:Anne Ferguson-Smith
-
依托单位:
Genomic imprinting and the epigenetic control of developmental processes
-
批准号:MR/R009791/1
-
项目类别:Research Grant
-
资助金额:$234.3万
-
财政年份:2018
-
负责人:Anne Ferguson-Smith
-
依托单位:
Genomic imprinting and the epigenetic control of developmental processes
-
批准号:MR/J001597/1
-
项目类别:Research Grant
-
资助金额:$189.09万
-
财政年份:2012
-
负责人:Anne Ferguson-Smith
-
依托单位:
The imprinted Dlk1 gene in development and metabolism: a model for epigenetic control of developmental programming
-
批准号:G0701196/1
-
项目类别:Research Grant
-
资助金额:$72.4万
-
财政年份:2008
-
负责人:Anne Ferguson-Smith
-
依托单位:
国内基金
海外基金
登录
查看更多内容
KRAB锌指蛋白调控tRNA引物结合位点抑制逆转录病毒元件的分子机制研究
-
批准号:32070652
-
项目类别:面上项目
-
资助金额:58.0万元
-
批准年份:2020
-
负责人:杨鹏
-
依托单位:
KRAB型锌指蛋白ZNF599对细胞核形态的影响及其机制研究
-
批准号:31701097
-
项目类别:青年科学基金项目
-
资助金额:24.0万元
-
批准年份:2017
-
负责人:刘楠
-
依托单位:
KRAB型锌指蛋白PITA和PISA与p53介导的细胞代谢调控关系研究
-
批准号:31571475
-
项目类别:面上项目
-
资助金额:65.0万元
-
批准年份:2015
-
负责人:宋珊珊
-
依托单位:
KRAB型锌指蛋白ZNF75D在基因转录调控及肿瘤发生发展中的作用
-
批准号:81372166
-
项目类别:面上项目
-
资助金额:75.0万元
-
批准年份:2013
-
负责人:易霞
-
依托单位:
候选抑癌基因KRAB-ZNF671启动子甲基化在鼻咽癌转移中调控E-cadherin表达的机制研究
-
批准号:81372409
-
项目类别:面上项目
-
资助金额:62.0万元
-
批准年份:2013
-
负责人:孙颖
-
依托单位:
KRAB型锌指蛋白Zfp445参与胚胎型-成熟型β珠蛋白基因表达转换的分子机制研究
-
批准号:81000192
-
项目类别:青年科学基金项目
-
资助金额:20.0万元
-
批准年份:2010
-
负责人:杨冬
-
依托单位:
KRAB型锌指蛋白家族中p53调控分子的筛选及功能研究
-
批准号:30871373
-
项目类别:面上项目
-
资助金额:30.0万元
-
批准年份:2008
-
负责人:郝冰涛
-
依托单位:
新型KRAB型锌指蛋白Krana:一种与ATM结合的p53负调控分子
-
批准号:30600310
-
项目类别:青年科学基金项目
-
资助金额:20.0万元
-
批准年份:2006
-
负责人:田春艳
-
依托单位: