HUMAN AGING AND VITAMIN D NUTRITION

人类衰老与维生素 D 营养

• 批准号: 3114757
• 负责人: JOHN L OMDAHL
• 金额: $ 8.12万
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 财政年份: 1983
• 资助国家: 美国
• 起止时间: 1983-07-01 至 1987-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3114757
• 关键词: 25 hydroxycholecalciferol; aging; calcium metabolism; cyclic AMP; dietary constituent; dietary trace element; gastrointestinal nutrient absorption; homeostasis; human subject; hydroxylation; immunoelectrophoresis; nutrition related tag; phosphorus metabolism; radioimmunoassay; vitamin D deficiency

Due to the vitamin D fortification program in the United States, it has been assumed that abnormal vitamin D nutrition is not a problem in old people. However, from the analysis of plasma 25-OHD concentrations in a group of 268 healthy free-living elderly people in the United States, we observed a 13.5 percent incidence rate for biochemically evident subclinical vitamin D deficiency. This research plan is designed to determine why the population of old people has a decreased plasma 25-hydroxyvitamin D concentration. Studies have been formulated to reveal the basis of the lowered 25-hydroxy-vitamin D levels and determine if the vitamin abnormality co-developed with changes in other calcium-homeostatic parameters, or occurred as an independent process. Genesis of the marginal vitamin D deficiency will be delineated by determining: 1) vitamin D nutritional status (food records with analysis by computerized nutrient-base program); 2) vitamin D biochemical status (measurement of plasma concentration for vitamin D and its hydroxylated metabolites); 3) efficiency of intestinal vitamin D and calcium absorption (double isotope methodology with calculation of rate constants); 4) concentration of the vitamin D binding protein (quantitated by rocket immunoelectrophoresis); and 5) mineral-metabolism activity (radioimmunoassay for plasma parathyroid hormone and nephrogenic cyclic-AMP). It is suggested from our preliminary results that low-vitamin D nutritional status is currently an unrecognized health concern for a substantial number of old people in the United States. If this observation is substantiated, then information from this investigation will serve as a touchstone for intervention studies into the prevention and treatment of age-related calcium-homeostatic diseases. And most importantly, it does not appear that a controlled study has been conducted in the United States on the influence of aging on vitamin D nutritional status.

由于在美国的维生素D强化计划，它具有 假设异常维生素D营养不是旧的问题 人们。 但是，从A的血浆25-OHD浓度分析 在美国，由268个健康自由生活的老年人组成的小组，我们 观察到生化的13.5％的发病率 亚临床维生素D缺乏。 该研究计划旨在 确定为什么老年人的人口减少等离子体 25-羟基维生素D浓度。 已经提出了研究以揭示 降低的25-羟基 - 维生素D水平的基础，并确定是否是否 维生素异常与其他钙家庭静脉曲张的变化共同开发 参数或作为独立过程发生。 mar 维生素D缺乏症将通过确定：1）维生素D 营养状况（用计算机分析的食物记录 营养基础计划）； 2）维生素D生化状态（测量 维生素D及其羟基化代谢产物的血浆浓度）； 3） 肠道维生素D和钙吸收的效率（双同位素 计算速率常数的方法）； 4）浓度 维生素D结合蛋白（由火箭免疫电泳定量）； 5）矿物质代谢活性（血浆甲状旁腺的放射免疫测定 激素和肾病性环境AMP）。 从我们的初步提出了 结果表明，低维生素D营养状况当前是未被发现的 对曼联大量老年人的健康关注 国家。 如果对此观察得到证实，则从此信息中获取信息 调查将作为干预研究的试金石 预防和治疗与年龄相关的钙家庭疾病。 和 最重要的是，似乎没有对照研究 在美国进行衰老对维生素D的影响 营养状况。