VITAMIN D SUPPLEMENTATION IN POSTMENOPAUSAL BLACK WOMEN
绝经后黑人女性补充维生素 D
基本信息
- 批准号:2769406
- 负责人:
- 金额:$ 10.28万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1997
- 资助国家:美国
- 起止时间:1997-09-01 至 2002-08-31
- 项目状态:已结题
- 来源:
- 关键词:1,25 dihydroxycholecalciferol 25 hydroxycholecalciferol African American aging blood chemistry bone density bone fracture bone metabolism calcium metabolism clinical research clinical trials dietary supplements female human middle age (35-64) human old age (65+) human subject human therapy evaluation interview longitudinal human study nutrition related tag osteoporosis outcomes research pathologic bone resorption photon absorptiometry placebos polymerase chain reaction postmenopause questionnaires statistics /biometry urinalysis vitamin D vitamin D deficiency vitamin D receptors vitamin receptor vitamin therapy women's health
项目摘要
Osteoporosis is a major public health problem throughout the world.
Although black women are believed to be at lower risk of osteoporotic
fracture than white women, the risk of fracture in postmenopausal
black women is still substantial. Blacks have consistently lower 25-
hydroxy-vitamin D levels and an elevation in parathyroid hormone
level compared to white women. These findings are consistent with
vitamin D insufficiency, or in some, true deficiency. Vitamin D
insufficiency has been implicated in bone loss with aging in the white
female population. furthermore, in white elderly women and men,
treatment with vitamin D has resulted in a lower rate of bone loss and
fractures. The effect of vitamin D supplementation has never been
evaluated in black women. We hypothesize that the presence of
relative 25(OH)D insufficiency that exists among black
postmenopausal women may exacerbate loss of bone among aging
black women. To test this hypothesis, we propose to conduct a
randomized clinical trial to compare vitamin D supplementation (1000
IU/ day) with placebo during a two year study in a population of 150
black postmenopausal (>5 years) women, who are shown to be
25(OH)D insufficient. We propose to determine whether supplemental
vitamin D (1000 IU) improves mineral metabolism, increases calcium
absorption, reduces bone turnover and reduces the rate of bone loss in
black postmenopausal women. In addition, we intend to determine
whether biochemical and bone density responses to vitamin D
supplementation in black women are related to allelic variation in the
vitamin D receptor. The fact that black women fracture less frequently
than white woman and tend to have higher bone mass has virtually
excluded this ethnic group from studies of osteoporosis treatment and
prevention. However, the fracture rate in black women is still
substantial. It is possible that a simple, safe nutritional supplement,
vitamin D, could reduce the rate of bone loss and risk of osteoporotic
fracture in black women.
骨质疏松症是全世界的一个主要公共卫生问题。
尽管黑人女性患骨质疏松症的风险较低
绝经后骨折风险高于白人女性
黑人女性的数量仍然很大。黑人的 25-
羟基维生素 D 水平和甲状旁腺激素升高
与白人女性相比。这些发现与
维生素 D 不足,或者在某些情况下,确实缺乏。维生素D
骨质缺乏与白种人衰老过程中的骨质流失有关
女性人口。此外,在白人老年妇女和男子中,
维生素 D 治疗可降低骨质流失率,
骨折。补充维生素D的效果从未有过
在黑人女性中进行了评估。我们假设存在
黑人中存在的 25(OH)D 相对不足
绝经后妇女可能会加剧衰老过程中的骨质流失
黑人妇女。为了检验这一假设,我们建议进行
比较维生素 D 补充剂的随机临床试验(1000
在一项针对 150 人的为期两年的研究中,使用安慰剂(IU/天)
黑人绝经后(>5 岁)女性,她们被证明
25(OH)D 不足。我们建议确定是否补充
维生素 D(1000 IU)改善矿物质代谢,增加钙含量
吸收,减少骨转换并降低骨丢失率
黑人绝经后妇女。 此外,我们打算确定
生化和骨密度是否对维生素 D 产生反应
黑人女性的补充与等位基因变异有关
维生素D受体。黑人女性骨折频率较低的事实
与白人女性相比,骨量往往更高
将这个种族排除在骨质疏松症治疗研究之外
预防。然而,黑人女性的骨折率仍然很高
重大的。一种简单、安全的营养补充剂可能
维生素D,可以降低骨质流失率和骨质疏松症的风险
黑人女性骨折。
项目成果
期刊论文数量(0)
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会议论文数量(0)
专利数量(0)
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JERI WANZOR NIEVES其他文献
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{{ truncateString('JERI WANZOR NIEVES', 18)}}的其他基金
PTH (1-34) and pelvic fracture healing: A randomized controlled trial
PTH (1-34) 和骨盆骨折愈合:一项随机对照试验
- 批准号:
10179318 - 财政年份:2019
- 资助金额:
$ 10.28万 - 项目类别:
PTH (1-34) and pelvic fracture healing: A randomized controlled trial
PTH (1-34) 和骨盆骨折愈合:一项随机对照试验
- 批准号:
9933509 - 财政年份:2019
- 资助金额:
$ 10.28万 - 项目类别:
PTH (1-34) and Pelvic Fracture Healing: A Randomized Controlled Trial
PTH (1-34) 和骨盆骨折愈合:随机对照试验
- 批准号:
9232321 - 财政年份:2017
- 资助金额:
$ 10.28万 - 项目类别:
Planning for PTH(1-34) and Pelvic Fracture Healing - Randomized Controlled Trial
PTH(1-34) 和骨盆骨折愈合规划 - 随机对照试验
- 批准号:
8627711 - 财政年份:2014
- 资助金额:
$ 10.28万 - 项目类别:
VITAMIN D SUPPLEMENTATION IN POSTMENOPAUSAL BLACK WOMEN
绝经后黑人女性补充维生素 D
- 批准号:
2395695 - 财政年份:1997
- 资助金额:
$ 10.28万 - 项目类别:
VITAMIN D SUPPLEMENTATION IN POSTMENOPAUSAL BLACK WOMEN
绝经后黑人女性补充维生素 D
- 批准号:
6372085 - 财政年份:1997
- 资助金额:
$ 10.28万 - 项目类别:
VITAMIN D SUPPLEMENTATION IN POSTMENOPAUSAL BLACK WOMEN
绝经后黑人女性补充维生素 D
- 批准号:
6055431 - 财政年份:1997
- 资助金额:
$ 10.28万 - 项目类别:
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