VITAMIN D SUPPLEMENTATION IN POSTMENOPAUSAL BLACK WOMEN

绝经后黑人女性补充维生素 D

• 批准号: 2769406
• 负责人: JERI WANZOR NIEVES
• 金额: $ 10.28万
• 依托单位: HELEN HAYES HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-01 至 2002-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2769406
• 关键词: 1,25 dihydroxycholecalciferol; 25 hydroxycholecalciferol; African American; aging; blood chemistry; bone density; bone fracture; bone metabolism; calcium metabolism; clinical research; clinical trials; dietary supplements; female; human middle age (35-64); human old age (65+); human subject; human therapy evaluation; interview; longitudinal human study; nutrition related tag; osteoporosis; outcomes research; pathologic bone resorption; photon absorptiometry; placebos; polymerase chain reaction; postmenopause; questionnaires; statistics /biometry; urinalysis; vitamin D; vitamin D deficiency; vitamin D receptors; vitamin receptor; vitamin therapy; women's health

Osteoporosis is a major public health problem throughout the world. Although black women are believed to be at lower risk of osteoporotic fracture than white women, the risk of fracture in postmenopausal black women is still substantial. Blacks have consistently lower 25- hydroxy-vitamin D levels and an elevation in parathyroid hormone level compared to white women. These findings are consistent with vitamin D insufficiency, or in some, true deficiency. Vitamin D insufficiency has been implicated in bone loss with aging in the white female population. furthermore, in white elderly women and men, treatment with vitamin D has resulted in a lower rate of bone loss and fractures. The effect of vitamin D supplementation has never been evaluated in black women. We hypothesize that the presence of relative 25(OH)D insufficiency that exists among black postmenopausal women may exacerbate loss of bone among aging black women. To test this hypothesis, we propose to conduct a randomized clinical trial to compare vitamin D supplementation (1000 IU/ day) with placebo during a two year study in a population of 150 black postmenopausal (>5 years) women, who are shown to be 25(OH)D insufficient. We propose to determine whether supplemental vitamin D (1000 IU) improves mineral metabolism, increases calcium absorption, reduces bone turnover and reduces the rate of bone loss in black postmenopausal women. In addition, we intend to determine whether biochemical and bone density responses to vitamin D supplementation in black women are related to allelic variation in the vitamin D receptor. The fact that black women fracture less frequently than white woman and tend to have higher bone mass has virtually excluded this ethnic group from studies of osteoporosis treatment and prevention. However, the fracture rate in black women is still substantial. It is possible that a simple, safe nutritional supplement, vitamin D, could reduce the rate of bone loss and risk of osteoporotic fracture in black women.

骨质疏松症是全世界的一个主要公共卫生问题。 尽管黑人女性患骨质疏松症的风险较低 绝经后骨折风险高于白人女性 黑人女性的数量仍然很大。黑人的 25- 羟基维生素 D 水平和甲状旁腺激素升高 与白人女性相比。这些发现与 维生素 D 不足，或者在某些情况下，确实缺乏。维生素D 骨质缺乏与白种人衰老过程中的骨质流失有关 女性人口。此外，在白人老年妇女和男子中， 维生素 D 治疗可降低骨质流失率， 骨折。补充维生素D的效果从未有过 在黑人女性中进行了评估。我们假设存在 黑人中存在的 25(OH)D 相对不足 绝经后妇女可能会加剧衰老过程中的骨质流失 黑人妇女。为了检验这一假设，我们建议进行 比较维生素 D 补充剂的随机临床试验（1000 在一项针对 150 人的为期两年的研究中，使用安慰剂（IU/天） 黑人绝经后（>5 岁）女性，她们被证明 25(OH)D 不足。我们建议确定是否补充 维生素 D（1000 IU）改善矿物质代谢，增加钙含量 吸收，减少骨转换并降低骨丢失率 黑人绝经后妇女。 此外，我们打算确定 生化和骨密度是否对维生素 D 产生反应 黑人女性的补充与等位基因变异有关 维生素D受体。黑人女性骨折频率较低的事实 与白人女性相比，骨量往往更高 将这个种族排除在骨质疏松症治疗研究之外 预防。然而，黑人女性的骨折率仍然很高 重大的。一种简单、安全的营养补充剂可能 维生素D，可以降低骨质流失率和骨质疏松症的风险 黑人女性骨折。