VITAMIN D SUPPLEMENTATION IN POSTMENOPAUSAL BLACK WOMEN
绝经后黑人女性补充维生素 D
基本信息
- 批准号:6372085
- 负责人:
- 金额:$ 4.29万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1997
- 资助国家:美国
- 起止时间:1997-09-01 至 2003-08-31
- 项目状态:已结题
- 来源:
- 关键词:1,25 dihydroxycholecalciferol 25 hydroxycholecalciferol African American aging blood chemistry bone density bone fracture bone metabolism calcium metabolism clinical research clinical trials dietary supplements female human middle age (35-64) human old age (65+) human subject human therapy evaluation interview longitudinal human study nutrition related tag osteoporosis outcomes research pathologic bone resorption photon absorptiometry placebos polymerase chain reaction postmenopause questionnaires statistics /biometry urinalysis vitamin D vitamin D deficiency vitamin D receptors vitamin receptor vitamin therapy women's health
项目摘要
Osteoporosis is a major public health problem throughout the world.
Although black women are believed to be at lower risk of osteoporotic
fracture than white women, the risk of fracture in postmenopausal
black women is still substantial. Blacks have consistently lower 25-
hydroxy-vitamin D levels and an elevation in parathyroid hormone
level compared to white women. These findings are consistent with
vitamin D insufficiency, or in some, true deficiency. Vitamin D
insufficiency has been implicated in bone loss with aging in the white
female population. furthermore, in white elderly women and men,
treatment with vitamin D has resulted in a lower rate of bone loss and
fractures. The effect of vitamin D supplementation has never been
evaluated in black women. We hypothesize that the presence of
relative 25(OH)D insufficiency that exists among black
postmenopausal women may exacerbate loss of bone among aging
black women. To test this hypothesis, we propose to conduct a
randomized clinical trial to compare vitamin D supplementation (1000
IU/ day) with placebo during a two year study in a population of 150
black postmenopausal (>5 years) women, who are shown to be
25(OH)D insufficient. We propose to determine whether supplemental
vitamin D (1000 IU) improves mineral metabolism, increases calcium
absorption, reduces bone turnover and reduces the rate of bone loss in
black postmenopausal women. In addition, we intend to determine
whether biochemical and bone density responses to vitamin D
supplementation in black women are related to allelic variation in the
vitamin D receptor. The fact that black women fracture less frequently
than white woman and tend to have higher bone mass has virtually
excluded this ethnic group from studies of osteoporosis treatment and
prevention. However, the fracture rate in black women is still
substantial. It is possible that a simple, safe nutritional supplement,
vitamin D, could reduce the rate of bone loss and risk of osteoporotic
fracture in black women.
骨质疏松症是世界范围内的一个主要公共卫生问题。
尽管黑人女性被认为患骨质疏松症的风险较低
骨折比白人女性绝经后骨折的风险大
黑人女性仍然占很大比例。黑人一直低于25%-
羟基维生素D水平与甲状旁腺激素的升高
与白人女性相比,这一水平更高。这些发现与
维生素D缺乏,在某些情况下,是真正的缺乏。维生素D
在白种人中,随着年龄的增长,骨量不足与骨质丢失有关。
女性人口。此外,在白人老年女性和男性中,
维生素D的治疗导致了较低的骨丢失率和
骨折。补充维生素D的效果从来没有
在黑人女性身上进行了评估。我们假设,
黑人中存在的相对25(OH)D不足
绝经后妇女在衰老过程中可能会加剧骨质流失
黑人女性。为了检验这一假设,我们建议进行一项
比较维生素D补充剂的随机临床试验(1000
国际单位/天)在一项为期两年的150人研究中使用安慰剂
绝经后(5岁)的黑人女性,她们被证明是
25(OH)D不足。我们建议确定补充方案是否
维生素D(1000IU)改善矿物质代谢,增加钙
吸收,减少骨转换,减少骨丢失的速度
绝经后的黑人女性。此外,我们打算确定
生化和骨密度对维生素D的反应
黑人女性的补充剂与等位基因变异有关
维生素D受体。黑人女性较少骨折的事实
与白人女性相比,往往有更高的骨量
将这一民族排除在骨质疏松症治疗和研究之外
预防。然而,黑人女性的骨折率仍然是
相当可观。一种简单、安全的营养补充剂,
维生素D,可以降低骨质流失和骨质疏松的风险
黑人女性的骨折。
项目成果
期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Calcium, vitamin D, and nutrition in elderly adults.
钙、维生素 D 和老年人的营养。
- DOI:10.1016/s0749-0690(02)00073-3
- 发表时间:2003
- 期刊:
- 影响因子:3.3
- 作者:Nieves,JeriW
- 通讯作者:Nieves,JeriW
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JERI WANZOR NIEVES其他文献
JERI WANZOR NIEVES的其他文献
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{{ truncateString('JERI WANZOR NIEVES', 18)}}的其他基金
PTH (1-34) and pelvic fracture healing: A randomized controlled trial
PTH (1-34) 和骨盆骨折愈合:一项随机对照试验
- 批准号:
10179318 - 财政年份:2019
- 资助金额:
$ 4.29万 - 项目类别:
PTH (1-34) and pelvic fracture healing: A randomized controlled trial
PTH (1-34) 和骨盆骨折愈合:一项随机对照试验
- 批准号:
9933509 - 财政年份:2019
- 资助金额:
$ 4.29万 - 项目类别:
PTH (1-34) and Pelvic Fracture Healing: A Randomized Controlled Trial
PTH (1-34) 和骨盆骨折愈合:随机对照试验
- 批准号:
9232321 - 财政年份:2017
- 资助金额:
$ 4.29万 - 项目类别:
Planning for PTH(1-34) and Pelvic Fracture Healing - Randomized Controlled Trial
PTH(1-34) 和骨盆骨折愈合规划 - 随机对照试验
- 批准号:
8627711 - 财政年份:2014
- 资助金额:
$ 4.29万 - 项目类别:
VITAMIN D SUPPLEMENTATION IN POSTMENOPAUSAL BLACK WOMEN
绝经后黑人女性补充维生素 D
- 批准号:
2395695 - 财政年份:1997
- 资助金额:
$ 4.29万 - 项目类别:
VITAMIN D SUPPLEMENTATION IN POSTMENOPAUSAL BLACK WOMEN
绝经后黑人女性补充维生素 D
- 批准号:
2769406 - 财政年份:1997
- 资助金额:
$ 4.29万 - 项目类别:
VITAMIN D SUPPLEMENTATION IN POSTMENOPAUSAL BLACK WOMEN
绝经后黑人女性补充维生素 D
- 批准号:
6169567 - 财政年份:1997
- 资助金额:
$ 4.29万 - 项目类别:
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