Pattern recognition receptors: discovery function and application in crops for durable disease control (PRR-CROP)

模式识别受体：发现功能及其在作物中持久疾病控制的应用（PRR-CROP）

• 批准号: BB/G024960/1
• 负责人: Christopher Ridout
• 金额: $ 47.41万
• 依托单位: John Innes Centre
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2009
• 资助国家: 英国
• 起止时间: 2009 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FG024960%2F1
• 关键词: Pattern; recognition; receptors; discovery; function

Plant diseases seriously limit the production of crops in European agriculture. The diseases can be controlled by chemicals, but ways to reduce chemical inputs are being sought. Sustainable agricultural methods are therefore placing increased emphasis on the genetic potential of plants to control pathogens. Resistance genes have been widely used in plant breeding to control diseases. However, pathogens readily evolve and mutate, which results in the 'break-down' of resistance genes in the field. Thus, an alternative, more durable form of resistance is required in sustainable agriculture. Recently, fundamental work with the model plant Arabidopsis thaliana has led to the discovery of a new class of proteins called Pattern Recognition Receptors (PRR's) which recognise essential conserved pathogen molecules that cannot be mutated or lost. These PRR's represent the first line of defence against potential pathogens, and offer the prospect of durable resistance to a broad range of diseases. This project advances our knowledge about PRR's so that it can be applied to crop plant species. We will concentrate on cereals, brassica and grapevine, and focus on PRR's that recognise the fungi and oomycetes which are the major pathogens of these crops. We will identify novel molecules from important crop pathogens that induce this first line of defence in plants. We will also look for new PRR's, both in Arabidopsis and crop plants, and investigate developmental and environmental effects on their performance. We will also test whether known PRR's function when transformed into crop plants. This is a joint project between European research groups in UK, Germany, Holland and France, and also involves collaboration with a seed company. The work will enable us to evaluate the potential of PRR's in breeding to provide durable disease control, so reducing the need for agrochemicals and benefitting the environment.

植物病害严重限制了欧洲农业的作物产量。这些疾病可以通过化学物质控制，但人们正在寻找减少化学物质投入的方法。因此，可持续农业方法越来越重视植物控制病原体的遗传潜力。抗性基因已被广泛应用于植物育种以控制病害。然而，病原体很容易进化和突变，这导致田间抗性基因的“分解”。因此，在可持续农业中需要一种替代的、更持久的抵抗形式。最近，对模式植物拟南芥的基础工作导致了一类新的蛋白质的发现，这种蛋白质称为模式识别受体(PRR)，它识别不能突变或丢失的基本保守的病原体分子。这些PRR代表了对潜在病原体的第一道防线，并提供了对广泛疾病的持久抵抗力的前景。这一项目增进了我们对PRR的认识，以便将其应用于农作物物种。我们将专注于谷物、甘蓝和葡萄，并专注于识别真菌和卵菌的PRR，这些真菌和卵菌是这些作物的主要病原体。我们将从重要的作物病原体中鉴定出诱导植物这第一道防线的新分子。我们还将在拟南芥和农作物中寻找新的PRR，并调查发育和环境对其性能的影响。我们还将测试是否已知PRR在转化作物时的功能。这是欧洲研究小组在英国、德国、荷兰和法国的联合项目，也涉及与一家种子公司的合作。这项工作将使我们能够评估PRR在育种中的潜力，以提供持久的疾病控制，从而减少对农用化学品的需求，并有利于环境。

项目成果

Anthocyanins double the shelf life of tomatoes by delaying overripening and reducing susceptibility to gray mold.

• DOI: 10.1016/j.cub.2013.04.072
• 发表时间: 2013-06-17
• 期刊: CURRENT BIOLOGY
• 影响因子: 9.2
• 作者: Zhang, Yang;Butelli, Eugenio;De Stefano, Rosalba;Schoonbeek, Henk-jan;Magusin, Andreas;Pagliarani, Chiara;Wellner, Nikolaus;Hill, Lionel;Orzaez, Diego;Granell, Antonio;Jones, Jonathan D. G.;Martin, Cathie
• 通讯作者: Martin, Cathie

Fungicide-driven evolution and molecular basis of multidrug resistance in field populations of the grey mould fungus Botrytis cinerea.

• DOI: 10.1371/journal.ppat.1000696
• 发表时间: 2009-12
• 期刊: PLoS pathogens
• 影响因子: 6.7
• 作者: Kretschmer M;Leroch M;Mosbach A;Walker AS;Fillinger S;Mernke D;Schoonbeek HJ;Pradier JM;Leroux P;De Waard MA;Hahn M
• 通讯作者: Hahn M

Detection of physically interacting proteins with the CC and NB-ARC domains of a putative yellow rust resistance protein, Yr10, in wheat

检测小麦中假定的黄锈病抗性蛋白 Yr10 的 CC 和 NB-ARC 结构域的物理相互作用蛋白

• DOI: 10.1007/bf03356391
• 发表时间: 2016
• 期刊: Journal of Plant Diseases and Protection
• 影响因子: 2
• 作者: Yildirim-Ersoy F