A cross-species investigation of individual differences in fear regulation

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This project aims to determine the utility of fibroblast growth factor 2 (FGF2), a naturally produced protein, as a biomarker of individual differences in fear responses, and as an enhancer of fear regulation. A cross-species translational approach will be employed, incorporating evidence from fear conditioning and extinction studies in rats, healthy humans, and clinical populations. The outcomes of this project are expected to show how natural variations in FGF2 levels are related to resilience following adversity, and how manipulations that increase FGF2 levels can augment resilience. The intended outcomes may lead to improved ways of identifying people who are at risk of developing anxiety, and novel ways of treating anxiety.