The impact of motherhood on fear extinction in rats

母性对大鼠恐惧消退的影响

• 批准号: DP180101563
• 负责人: Prof Bronwyn Graham
• 金额: $ 22.99万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2022-12-29
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP180101563
• 关键词: impact; motherhood; fear; extinction; rats

This project aims to identify how motherhood, a time of significant hormonal flux, alters the mechanisms underlying fear regulation in female rats. Current theories of fear regulation are limited because they have been derived from studies that have focused on males but recent work suggests that sex hormones influence fear regulation. The expected outcomes of this project will help to develop a more ecologically valid model of fear regulation that accounts for fluctuations in female sex hormones and reproductive experience. This should provide unique insights into fear reduction and protection against anxiety.

这个项目的目的是确定如何母性，一个显着的激素流量的时间，改变机制的基础上的恐惧调节雌性大鼠。目前关于恐惧调节的理论是有限的，因为它们来自于专注于男性的研究，但最近的工作表明性激素影响恐惧调节。该项目的预期成果将有助于开发一个更生态有效的恐惧调节模型，该模型解释了女性性激素和生殖经验的波动。这应该为减少恐惧和防止焦虑提供独特的见解。