How hormones help to overcome fear: from rats to humans

激素如何帮助克服恐惧：从老鼠到人类

• 批准号: DP220101339
• 负责人: Prof Bronwyn Graham
• 金额: $ 31.74万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-04-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP220101339
• 关键词: How; hormones; help; overcome; fear

This project aims to identify how sex hormones regulate the ability to overcome fear in male and female rats, and test the translation of these mechanisms in humans. Current theories of how we overcome fear are severely limited because they were derived from studies that overwhelmingly focused on males, and the impact of sex hormones has been relatively ignored in both sexes. This project is significant because it will lead to the development of ecologically valid, sex-specific models of how we overcome fear. The outcomes will illustrate how underlying mechanisms of fear regulation differ between males and females, and will provide a foundation from which future research can develop sex-specific means of optimising treatments for anxiety.

该项目旨在确定性激素如何调节雄性和雌性大鼠克服恐惧的能力，并测试这些机制在人类中的翻译。目前关于我们如何克服恐惧的理论是非常有限的，因为它们来自于绝大多数集中在男性身上的研究，而性激素的影响在两性中相对被忽视。这个项目意义重大，因为它将导致我们如何克服恐惧的生态有效性，性别特异性模型的发展。这些结果将说明男性和女性之间恐惧调节的潜在机制是如何不同的，并将为未来的研究提供一个基础，可以开发出优化焦虑治疗的性别特异性方法。