How hormones help to overcome fear: from rats to humans

该项目旨在确定性激素如何调节雄性和雌性大鼠克服恐惧的能力，并测试这些机制在人类中的翻译。目前关于我们如何克服恐惧的理论受到严重限制，因为它们是从压倒性地专注于男性的研究中得出的，而性激素的影响在两性中相对被忽视了。这个项目意义重大，因为它将导致开发出生态上有效的、针对性别的我们如何克服恐惧的模型。这些结果将说明男性和女性之间潜在的恐惧调节机制是如何不同的，并将为未来的研究提供一个基础，以此为基础开发针对性别的优化焦虑治疗方法。

This project aims to identify how sex hormones regulate the ability to overcome fear in male and female rats, and test the translation of these mechanisms in humans. Current theories of how we overcome fear are severely limited because they were derived from studies that overwhelmingly focused on males, and the impact of sex hormones has been relatively ignored in both sexes. This project is significant because it will lead to the development of ecologically valid, sex-specific models of how we overcome fear. The outcomes will illustrate how underlying mechanisms of fear regulation differ between males and females, and will provide a foundation from which future research can develop sex-specific means of optimising treatments for anxiety.