How do females overcome fear? New insights from the maternal brain

女性如何克服恐惧？

• 批准号: DP220103708
• 负责人: Prof Bronwyn Graham
• 金额: $ 30.1万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-12-30 至 2025-12-29
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP220103708
• 关键词: How; do; females; overcome; fear

This project aims to identify how the mechanisms underlying fear regulation shift as a function of pregnancy, a female-unique biological event that leads to profound and enduring changes within fear-relevant brain regions. The outcomes of this project will substantially advance current, male-based theories of fear regulation by generating new knowledge on fear regulation in females that is tailored to their reproductive status. This aligns with international priority calls to close the knowledge gap on fundamental processes in females. This new knowledge will provide a foundation to improve treatments for anxiety disorders in women, who are twice more prone to such conditions than men, particularly during the peripartum period.

该项目旨在确定恐惧调节机制如何随着怀孕而变化，怀孕是一种女性特有的生物事件，导致恐惧相关脑区发生深刻而持久的变化。该项目的成果将大大推进目前的，基于男性的恐惧调节理论，产生新的知识，恐惧调节女性，是适合他们的生殖状态。这符合国际优先呼吁，即缩小女性基本过程的知识差距。这一新知识将为改善妇女焦虑症的治疗提供基础，妇女患焦虑症的可能性是男子的两倍，特别是在围产期。