How do females overcome fear? New insights from the maternal brain

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This project aims to identify how the mechanisms underlying fear regulation shift as a function of pregnancy, a female-unique biological event that leads to profound and enduring changes within fear-relevant brain regions. The outcomes of this project will substantially advance current, male-based theories of fear regulation by generating new knowledge on fear regulation in females that is tailored to their reproductive status. This aligns with international priority calls to close the knowledge gap on fundamental processes in females. This new knowledge will provide a foundation to improve treatments for anxiety disorders in women, who are twice more prone to such conditions than men, particularly during the peripartum period.