Contribution of local- and circuit-based mechanisms to adaptive coding in the auditory midbrain

对普遍存在的感觉信息进行准确编码的能力对动物的生存至关重要，而大脑机制已经进化到能够以最佳方式从环境中提取这些信息。作为这种能力的一部分，许多感觉神经元似乎能够“实时”调整它们的神经调谐，以考虑正在展开的感觉环境。这种所谓的“自适应编码”通常会提高周围感官环境编码的准确性。这是如何在大脑中实现的，还有待确定，无论是从细胞机制还是从大脑回路的角度来看，大脑回路对任何一个大脑中心的适应性编码都有贡献。我们的实验将研究自适应编码的三个具体方面。首先，他们将确定神经元内部的机制，这些机制有助于对声音中呈现的声音强度进行自适应编码。其次，他们将评估皮层反馈对低脑中心适应性编码的贡献。虽然感觉信息被认为是从耳朵的外围听觉传感器“流”到大脑皮层等更高的大脑中心，但我们也知道存在大量的皮层反馈回路。这些反馈回路的功能尚不清楚，但我实验室的初步证据表明，其中一个作用是修改听觉中脑的自适应编码，增加神经元在主要声音环境突然改变时优化其对声音强度的敏感性所需的时间。最后，实验还将检查当前听到的刺激特征的适应性编码是如何具体的，评估神经元对一个刺激参数（例如声强）的反应是否也意味着响应适应声源位置，例如。

The ability to code accurately the prevailing sensory information is critical to an animal's survival, and brain mechanisms have evolved that enable this information to be extracted from the environment in an optimal manner. As part of this ability, many sensory neurons appear able to adjust their neural tuning in 'real-time' to take account of the unfolding sensory environment. This so-called 'adaptive coding' often results in improved accuracy with which the ambient sensory environment is coded. How this is achieved in the brain remains to be determined, both in terms of cellular mechanisms and in terms of brain circuits that contribute to adaptive coding in any one brain centre. Our experiments will investigate three specific aspects of adaptive coding. First, they will determine mechanisms within neurons themselves that contribute to adaptive coding for the unfolding sound intensities present in a sound. Second, they will assess the contribution of cortical feedback on adaptive coding in lower brain centres. Although sensory information is thought to 'flow' from the peripheral hearing sensors in the ears towards higher brain centres such as the cortex, a substantial number of cortical feedback circuits are also known to exist. The function of these feddback circuits remains unclear, but preliminary evidence from my laboratory suggests that one role is to modify adaptive coding in the auditory midbrain, increasing the time taken by neurons to optimise their sensitivity to sound intensity when the prevailing sound enviroment suddenly changes. Finally, experiments will also examine how specific adaptive coding is for the stimulus feature currently being heard, assessing whether or not adapting a neuron's response to one stimulus parameter (e.g. sound intensity) also means that the responses are adapted to sound-source location, for example.