ANTIGEN RECOGNITITON BY CYTOTOXIC T LYMPHOCYTES
ANTIGEN RECOGNITITON BY CYTOTOXIC T LYMPHOCYTES
批准号:
3126005
负责人:
DAVID P FAN
金额:
$14.76万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1978
资助国家:
美国
项目状态:
已结题
起止时间:
1978-08-01 至 1987-06-30
中文摘要
这项工作涉及阐明被识别的抗原决定因素
细胞溶解胸腺依赖淋巴细胞(CTL)。我们已经发现了这种多肽
仙台病毒和流感病毒的糖蛋白片段都可以刺激这些
小鼠脾细胞体外CTL。一个主要目标是隔离和
对刺激片段的结构进行生化表征。我们会
进一步测试这些片段在体内的生理作用
抗体的诱导和CTL的形成。此外,我们还将表演
与Thomas Braciale博士在圣路易斯合作进行实验
我们的片段与克隆T细胞在长期培养中的相互作用
了解这些片段与单个T细胞的直接相互作用。我们
还将尝试将流感糖蛋白从脂质体转移到
以仙台HN和F蛋白为载体的CTL靶细胞。
英文摘要
This work concerns the elucidation of the antigenic determinants recognized by
cytolytic thymus-dependent lymphocytes (CTL). We have found that peptide
fragments of both Sendai and influenza viral glycoproteins can stimulate these
CTL in vitro from mouse spleen cells. One major goal is to isolate and
characterize biochemically the structure of the stimulatory fragments. We will
further test the physiological roles of these fragments in vivo with respect to
induction of antibody and CTL formation. We will, in addition, be performing
collaborative experiments together with Dr. Thomas Braciale in St. Louis to test
the interactions of our fragments with cloned T cells in long term culture to
understand the direct interaction of the fragments with individual T cells. We
will also attempt to transfer the influenza glycoproteins from a liposome to a
target cell for CTL using the Sendai HN and F proteins as carriers.
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Assessing Information Impact on Smoking Time Trends
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批准号:6724084
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项目类别:
-
资助金额:$12.52万
-
财政年份:2004
-
负责人:DAVID P FAN
-
依托单位:
MATHEMATICAL MODEL FOR THE EVOLUTION OF IDEAS
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批准号:3377501
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项目类别:
-
资助金额:$12.07万
-
财政年份:1987
-
负责人:DAVID P FAN
-
依托单位:
MATHEMATICAL MODEL FOR THE EVOLUTION OF IDEAS
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批准号:3377502
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项目类别:
-
资助金额:$13.1万
-
财政年份:1987
-
负责人:DAVID P FAN
-
依托单位:
MATHEMATICAL MODEL FOR THE EVOLUTION OF IDEAS
-
批准号:3377500
-
项目类别:
-
资助金额:$12.23万
-
财政年份:1987
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负责人:DAVID P FAN
-
依托单位:
CYTOLYTIC T LYMPHOCYTE HELPER FACTOR
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批准号:3172812
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项目类别:
-
资助金额:$18.06万
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财政年份:1984
-
负责人:DAVID P FAN
-
依托单位:
CYTOLYTIC T LYMPHOCYTE HELPER FACTOR
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批准号:3172814
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项目类别:
-
资助金额:$8.85万
-
财政年份:1984
-
负责人:DAVID P FAN
-
依托单位:
CYTOLYTIC T LYMPHOCYTE HELPER FACTOR
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批准号:3172816
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项目类别:
-
资助金额:$19.35万
-
财政年份:1984
-
负责人:DAVID P FAN
-
依托单位:
CYTOLYTIC T LYMPHOCYTE HELPER FACTOR
-
批准号:3172817
-
项目类别:
-
资助金额:$19.45万
-
财政年份:1984
-
负责人:DAVID P FAN
-
依托单位:
CYTOLYTIC T LYMPHOCYTE HELPER FACTOR
-
批准号:3172815
-
项目类别:
-
资助金额:$8.78万
-
财政年份:1984
-
负责人:DAVID P FAN
-
依托单位:
CYTOLYTIC T LYMPHOCYTE HELPER FACTOR
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批准号:3172813
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项目类别:
-
资助金额:$18.66万
-
财政年份:1984
-
负责人:DAVID P FAN
-
依托单位:
ANTIGEN RECOGNITION BY CYTOTOXIC T LYMPHOCYTES.
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批准号:3126006
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项目类别:
-
资助金额:$13.48万
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财政年份:1978
-
负责人:DAVID P FAN
-
依托单位:
海外基金