ANTIGEN RECOGNITITON BY CYTOTOXIC T LYMPHOCYTES
ANTIGEN RECOGNITITON BY CYTOTOXIC T LYMPHOCYTES
批准号:
3126005
负责人:
DAVID P FAN
金额:
$14.76万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1978
资助国家:
美国
项目状态:
已结题
起止时间:
1978-08-01 至 1987-06-30
中文摘要
这项工作涉及到的抗原决定因子的阐明
英文摘要
This work concerns the elucidation of the antigenic determinants recognized by
cytolytic thymus-dependent lymphocytes (CTL). We have found that peptide
fragments of both Sendai and influenza viral glycoproteins can stimulate these
CTL in vitro from mouse spleen cells. One major goal is to isolate and
characterize biochemically the structure of the stimulatory fragments. We will
further test the physiological roles of these fragments in vivo with respect to
induction of antibody and CTL formation. We will, in addition, be performing
collaborative experiments together with Dr. Thomas Braciale in St. Louis to test
the interactions of our fragments with cloned T cells in long term culture to
understand the direct interaction of the fragments with individual T cells. We
will also attempt to transfer the influenza glycoproteins from a liposome to a
target cell for CTL using the Sendai HN and F proteins as carriers.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Assessing Information Impact on Smoking Time Trends
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批准号:6724084
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项目类别:
-
资助金额:$12.52万
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财政年份:2004
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负责人:DAVID P FAN
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依托单位:
MATHEMATICAL MODEL FOR THE EVOLUTION OF IDEAS
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批准号:3377501
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项目类别:
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资助金额:$12.07万
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财政年份:1987
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负责人:DAVID P FAN
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依托单位:
MATHEMATICAL MODEL FOR THE EVOLUTION OF IDEAS
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批准号:3377500
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项目类别:
-
资助金额:$12.23万
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财政年份:1987
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负责人:DAVID P FAN
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依托单位:
MATHEMATICAL MODEL FOR THE EVOLUTION OF IDEAS
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批准号:3377502
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项目类别:
-
资助金额:$13.1万
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财政年份:1987
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负责人:DAVID P FAN
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依托单位:
CYTOLYTIC T LYMPHOCYTE HELPER FACTOR
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批准号:3172812
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项目类别:
-
资助金额:$18.06万
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财政年份:1984
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负责人:DAVID P FAN
-
依托单位:
CYTOLYTIC T LYMPHOCYTE HELPER FACTOR
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批准号:3172814
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项目类别:
-
资助金额:$8.85万
-
财政年份:1984
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负责人:DAVID P FAN
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依托单位:
CYTOLYTIC T LYMPHOCYTE HELPER FACTOR
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批准号:3172816
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项目类别:
-
资助金额:$19.35万
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财政年份:1984
-
负责人:DAVID P FAN
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依托单位:
CYTOLYTIC T LYMPHOCYTE HELPER FACTOR
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批准号:3172817
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项目类别:
-
资助金额:$19.45万
-
财政年份:1984
-
负责人:DAVID P FAN
-
依托单位:
CYTOLYTIC T LYMPHOCYTE HELPER FACTOR
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批准号:3172815
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项目类别:
-
资助金额:$8.78万
-
财政年份:1984
-
负责人:DAVID P FAN
-
依托单位:
CYTOLYTIC T LYMPHOCYTE HELPER FACTOR
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批准号:3172813
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项目类别:
-
资助金额:$18.66万
-
财政年份:1984
-
负责人:DAVID P FAN
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依托单位:
ANTIGEN RECOGNITION BY CYTOTOXIC T LYMPHOCYTES.
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批准号:3126006
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项目类别:
-
资助金额:$13.48万
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财政年份:1978
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负责人:DAVID P FAN
-
依托单位:
海外基金