STRUCTURE OF ANTIBODY MOLECULES AND CELL MEMBRANES

这项研究计划规划了三个主要的研究领域。 A)细胞运动和趋化的分子机制将进一步 探索，特别注意插入新的膜 质量进入细胞前沿作为细胞的关键特征 分机。此外，针对关键细胞表面的单抗 将寻找与趋化和细胞运动有关的成分。 B)盖帽和相关细胞的分子机制 将研究表面-细胞骨架的相互作用，重点是 我们生产的单抗似乎是针对一种 与肌动蛋白微丝相关的完整蛋白质 细胞膜。 C)与自然杀伤细胞的细胞毒性有关的细胞内事件 而细胞毒性T淋巴细胞(CTL)将在一个系统中进一步探索 涉及对感染的靶细胞CTL的限制性识别 淋巴细胞性脉络膜脑膜炎病毒(LCMV)，与其细胞性质有关 从目标细胞到效应细胞的表面信令事件将是 探索过了。

Three major areas of study are projected in this research program. a) The molecular mechanisms of cell motility and chemotaxis will be further explored, with particular attention paid to the insertion of new membrane mass into the leading edge of a cell as a critical feature of cell extension. In addition, monoclonal antibodies directed to key cell surface components involved in chemotaxis and cell motility will be sought for. b) The molecular mechanisms involved in capping and related cell surface - cytoskeletal interactions will be investigated, focusing on a monoclonal antibody we have produced that appears to be directed to an integral protein that is associated with actin microfilaments underlying the cell membrane. c) The intracellular events involved in cytoxicity by natural killer cells and cytotoxic T lymphocytes (CTL) will be further explored in a system involving restricted recognition of CTL of target cells infected with lymphocytic choriomeningitis virus (LCMV), with which the nature of cell surface signalling events from the target cell to the effector cell will be explored.