ADAPTATION TO ANTIBIOTIC RESISTANCE IN MUCOR

本研究的目的是探索适应性抗生素 真菌毛霉的耐药性。 尽管最初对 放线菌酮、黄曲霉素和黄曲霉素B，毛霉将“适应” 几个小时后服用抗生素。 这种适应涉及所有的 细胞在人群中，并没有导致破坏的 抑制剂的 数据显示，适应细胞将修饰C14-脱表皮素， 可能产生不活跃的形式。 这种抗生素适应性将是 通过研究探讨：（1）改性的机制， 抗生素的适应细胞，和（2）辅助机制，包括 毒品的运输和封存 将促进这些研究 通过改变对三种突变体的反应， 抗生素 这些突变体分为两类： 对抗生素有抗性并且超敏感（即，无适应性反应）。

The purpose of this research is to investigate the adaptive antibiotic resistance of the fungus Mucor. Although initially sensitive to the cycloheximide, trichodermin, and amphotericin B, Mucor will "adapt" to these antibiotics after several hours. This adaptation involves all the cells in the population, and does not result in the destruction of the inhibitors. Data show that adapted cells will modify C14-trichodermin, presumably producing inactive forms. This antibiotic adaptation will be investigated by studying: (1) mechanisms for the modification of antibiotics by adapted cells, and (2) subsidiary mechanisms, including the transport and sequestering of the drugs. These studies will be facilitated by the availability of mutants with altered responses to the three antibiotics. These mutants fall into two classes: constitutively resistant to antibiotics and super sensitive (i.e., no adaptive response).