ADAPTATION TO ANTIBIOTIC RESISTANCE IN MUCOR

本研究的目的是研究适应性抗生素 真菌毛霉的抗性。尽管最初对 放线菌素、霉菌素和两性霉素B，毛霉将“适应” 这些抗生素在几个小时后。这一适应涉及所有 种群中的细胞，并且不会导致 抑制剂。数据显示，适应的细胞将修饰C14-毛发蛋白， 想必是在制造不活跃的形态。这种抗生素的适应将是 通过研究考察：(1)改性的机理 适应细胞的抗生素，以及(2)辅助机制，包括 运输和封存毒品。这些研究将得到便利 通过改变对这三种基因的反应的突变体的可用性 抗生素。这些突变体分为两类：结构性的 对抗生素耐药和超敏感(即无适应性反应)。

The purpose of this research is to investigate the adaptive antibiotic resistance of the fungus Mucor. Although initially sensitive to the cycloheximide, trichodermin, and amphotericin B, Mucor will "adapt" to these antibiotics after several hours. This adaptation involves all the cells in the population, and does not result in the destruction of the inhibitors. Data show that adapted cells will modify C14-trichodermin, presumably producing inactive forms. This antibiotic adaptation will be investigated by studying: (1) mechanisms for the modification of antibiotics by adapted cells, and (2) subsidiary mechanisms, including the transport and sequestering of the drugs. These studies will be facilitated by the availability of mutants with altered responses to the three antibiotics. These mutants fall into two classes: constitutively resistant to antibiotics and super sensitive (i.e., no adaptive response).