MOLECULAR BIOLOGY OF INVASIVENESS OF CANDIDA ALBICANS

这项研究的目标是为以下方面提供分子基础： 了解念珠菌的侵袭机制 艾滋病患者中的白色念珠菌 研究将从 比较明确的事实是C.白色念珠菌，必须粘附并定植 细胞作为建立感染的阶段。 我们将使用两个 方法：（1）研究失去能力的突变体， 粘附于动物细胞，随后为非致病性的，和 (2)一项关于芽管特异性蛋白作为一种手段的研究， 了解芽管穿透在 侵略性 我们将使用基因克隆技术来研究 影响这些入侵特性的表达。

The goal of this research is to provide a molecular basis for understanding the mechanisms for invasiveness of Candida albicans in AIDS patients. The research will start with the relatively clear fact that C. albicans, must adhere to and colonize cells as a stage in establishing an infection. We will use two approaches: (1) a study of mutants that have lost the ability to adhere to animal cells and are subsequently non-pathogenic, and (2) a study of a germ tube-specific protein as a means of understanding the role germ tube penetration plays in invasiveness. We will use gene cloning techniques to study factors that affect the expression of these properties of invasiveness.