MOLECULAR BIOLOGY OF INVASIVENESS OF CANDIDA ALBICANS

本研究的目的是为人类免疫缺陷的研究提供分子基础 对念珠菌侵袭机制的认识 艾滋病患者中的白念珠菌。这项研究将从 相对明确的事实是，白色念珠菌必须附着和定居 细胞作为建立感染的一个阶段。我们将使用两个 研究方法：(1)对已丧失 附着在动物细胞上，因此是非致病的，并且 (2)一种胚管特异性蛋白作为一种手段的研究 了解生殖管穿透在 侵犯性。我们将使用基因克隆技术来研究因素 会影响这些侵入性属性的表达。

The goal of this research is to provide a molecular basis for understanding the mechanisms for invasiveness of Candida albicans in AIDS patients. The research will start with the relatively clear fact that C. albicans, must adhere to and colonize cells as a stage in establishing an infection. We will use two approaches: (1) a study of mutants that have lost the ability to adhere to animal cells and are subsequently non-pathogenic, and (2) a study of a germ tube-specific protein as a means of understanding the role germ tube penetration plays in invasiveness. We will use gene cloning techniques to study factors that affect the expression of these properties of invasiveness.