BICYCLOMYCIN SYNTHESIS AND ANTIBIOTIC BIOMECHANISM

双环霉素的合成和抗生素生物机制

• 批准号: 3128350
• 负责人: Robert Michael Williams
• 金额: $ 6.77万
• 依托单位: COLORADO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1982
• 资助国家: 美国
• 起止时间: 1982-05-01 至 1988-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3128350
• 关键词: antineoplastic antibiotics; drug design /synthesis /production; drug metabolism; saturated /unsaturated bonds

The objective of the proposed research is the total synthesis of the novel antibiotic bicyclomycin in optically active form and of select bicyclomycin analogs to be used in evaluating the chemical mechanism of antibacterial action of bicyclomycin. New synthetic methods for constructing the bicyclomycin ring system will be investigated. The synthetic strategem is of sufficient bravity and versatility to allow the elaboration of bicyclomycin and all synthetic analogs from a few common intermediates. By these methods, the chemical structural and dynamic properties of the bicyclomycin ring system as a "latent" Alpha,Beta-unsaturated pryuvamide (Michael acceptor) will be investigated.

建议的研究的目标是小说的全合成 光学活性形式的抗生素双环霉素和选择的双环霉素 类似物用于评价抗菌的化学机制 双环霉素的作用。 新的合成方法， 双环霉素环系统将被研究。 合成策略是 有足够的勇气和灵活性， 双环霉素和所有合成类似物从几个常见的中间体。 通过 这些方法，化学结构和动态性能的， 双环霉素环系统作为“潜在的”α，β-不饱和的普鲁夫酰胺 （迈克尔·接受者）将接受调查。