400 MHz NMR Spectrometer for CSU Chemistry Facility

用于 CSU 化学设施的 400 MHz NMR 波谱仪

• 批准号: 7390018
• 负责人: Robert Michael Williams
• 金额: $ 25.08万
• 依托单位: COLORADO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7390018
• 关键词: 10 year old; Aging; Biological Factors; Chemistry; Colorado; Disease; Funding; Laboratories; Leprosy; Performance; Personal Satisfaction; Pharmaceutical Preparations; Resolution; System; Time; Tuberculosis; United States National Institutes of Health; Universities; Walking; Work; instrument; instrumentation

DESCRIPTION (provided by applicant): The Chemistry Department at Colorado State University is requesting funds to purchase a new 400 MHz NMR spectrometer that will replace our ten year old 300 NMR. The instrument will be managed within the Department's Central Instrumentation Facility (CIF). At the present time, we do the greatest portion of our NMR work on three heavily used instruments, one of which - the subject of this proposal - is well past its prime. This instrument is used for routine NMR studies in a walk-up mode. The new, 400 NMR is needed at this time to replace the aging and technically limited 300 NMR. It offers significantly better sensitivity, resolution and performance compared with the 300 NMR that it replaces. Indeed, the NMR performance is sufficiently good that we expect to do some kinds of NMR, e.g. C and fast 2D, on this new 400 NMR rather than on the more powerful 13 instruments in the CIF as we do at present. Finally, the actively shielded magnet provides for a much smaller overall system footprint and will allow us to make better use of valuable laboratory space. The 400 MHz NMR spectrometer requested provides analytical support to NIH funded projects that discover new synthetic strategies for producing pharmacologically important drug materials efficiently and in high purity. The instrument also supports NIH funded projects that discover new natural products that may be tomorrow's wonder drugs for some of the world's worst diseases including tuberculosis and leprosy.

描述（由申请人提供）：科罗拉多州立大学化学系正在申请资金购买一台新的 400 MHz NMR 波谱仪，以取代我们使用了 10 年的 300 NMR。该仪器将在该部门的中央仪器设施（CIF）内进行管理。目前，我们的 NMR 工作大部分是在三台常用仪器上完成的，其中一台（本提案的主题）已经过了鼎盛时期。该仪器用于以直接模式进行常规 NMR 研究。此时需要新的 400 NMR 来取代老化且技术有限的 300 NMR。与它所取代的 300 NMR 相比，它提供了明显更好的灵敏度、分辨率和性能。事实上，核磁共振性能足够好，我们期望进行某些类型的核磁共振，例如核磁共振。 C 和快速 2D，在这个新的 400 NMR 上，而不是像我们目前在 CIF 中更强大的 13 台仪器上。最后，主动屏蔽磁体提供了更小的整体系统占地面积，并使我们能够更好地利用宝贵的实验室空间。所需的 400 MHz NMR 波谱仪为 NIH 资助的项目提供分析支持，这些项目发现新的合成策略，以有效、高纯度地生产药理学上重要的药物材料。该仪器还支持 NIH 资助的项目，这些项目发现新的天然产品，这些产品可能成为明天治疗结核病和麻风病等世界上一些最严重疾病的神奇药物。