400 MHz NMR Spectrometer for CSU Chemistry Facility

描述（由申请人提供）：科罗拉多州立大学的化学系正在申请资金购买一台新的400 MHz NMR光谱仪，以取代我们使用了十年的300 MHz NMR。该仪器将在该部的中央仪器设施内管理。目前，我们的核磁共振工作的最大部分是在三种常用仪器上进行的，其中之一--本提案的主题--已经过了全盛时期。该仪器用于在步行模式下进行常规NMR研究。新的，400核磁共振是需要在这个时候，以取代老化和技术上有限的300核磁共振。与它所取代的300 NMR相比，它具有更高的灵敏度、分辨率和性能。事实上，NMR性能足够好，我们希望在这种新的400 NMR上进行某些类型的NMR，例如C和快速2D，而不是像我们目前所做的那样在CIF中更强大的13台仪器上。最后，主动屏蔽磁体提供了更小的整体系统占地面积，并将使我们能够更好地利用宝贵的实验室空间。所要求的400 MHz NMR光谱仪为NIH资助的项目提供分析支持，这些项目旨在发现新的合成策略，以有效和高纯度地生产非常重要的药物材料。该仪器还支持美国国立卫生研究院资助的项目，发现新的天然产品，这些产品可能是未来治疗世界上一些最严重疾病的神奇药物，包括结核病和麻风病。

DESCRIPTION (provided by applicant): The Chemistry Department at Colorado State University is requesting funds to purchase a new 400 MHz NMR spectrometer that will replace our ten year old 300 NMR. The instrument will be managed within the Department's Central Instrumentation Facility (CIF). At the present time, we do the greatest portion of our NMR work on three heavily used instruments, one of which - the subject of this proposal - is well past its prime. This instrument is used for routine NMR studies in a walk-up mode. The new, 400 NMR is needed at this time to replace the aging and technically limited 300 NMR. It offers significantly better sensitivity, resolution and performance compared with the 300 NMR that it replaces. Indeed, the NMR performance is sufficiently good that we expect to do some kinds of NMR, e.g. C and fast 2D, on this new 400 NMR rather than on the more powerful 13 instruments in the CIF as we do at present. Finally, the actively shielded magnet provides for a much smaller overall system footprint and will allow us to make better use of valuable laboratory space. The 400 MHz NMR spectrometer requested provides analytical support to NIH funded projects that discover new synthetic strategies for producing pharmacologically important drug materials efficiently and in high purity. The instrument also supports NIH funded projects that discover new natural products that may be tomorrow's wonder drugs for some of the world's worst diseases including tuberculosis and leprosy.