400 MHz NMR Spectrometer for CSU Chemistry Facility

用于 CSU 化学设施的 400 MHz NMR 波谱仪

• 批准号: 7390018
• 负责人: Robert Michael Williams
• 金额: $ 25.08万
• 依托单位: COLORADO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7390018
• 关键词: 10 year old; Aging; Biological Factors; Chemistry; Colorado; Disease; Funding; Laboratories; Leprosy; Performance; Personal Satisfaction; Pharmaceutical Preparations; Resolution; System; Time; Tuberculosis; United States National Institutes of Health; Universities; Walking; Work; instrument; instrumentation

DESCRIPTION (provided by applicant): The Chemistry Department at Colorado State University is requesting funds to purchase a new 400 MHz NMR spectrometer that will replace our ten year old 300 NMR. The instrument will be managed within the Department's Central Instrumentation Facility (CIF). At the present time, we do the greatest portion of our NMR work on three heavily used instruments, one of which - the subject of this proposal - is well past its prime. This instrument is used for routine NMR studies in a walk-up mode. The new, 400 NMR is needed at this time to replace the aging and technically limited 300 NMR. It offers significantly better sensitivity, resolution and performance compared with the 300 NMR that it replaces. Indeed, the NMR performance is sufficiently good that we expect to do some kinds of NMR, e.g. C and fast 2D, on this new 400 NMR rather than on the more powerful 13 instruments in the CIF as we do at present. Finally, the actively shielded magnet provides for a much smaller overall system footprint and will allow us to make better use of valuable laboratory space. The 400 MHz NMR spectrometer requested provides analytical support to NIH funded projects that discover new synthetic strategies for producing pharmacologically important drug materials efficiently and in high purity. The instrument also supports NIH funded projects that discover new natural products that may be tomorrow's wonder drugs for some of the world's worst diseases including tuberculosis and leprosy.

描述（由申请人提供）：科罗拉多州立大学化学系正在申请资金购买一台新的400 MHz核磁共振光谱仪，以取代我们10年的300核磁共振光谱仪。该仪器将在该部的中央仪器设施（CIF）内进行管理。目前，我们在三种被大量使用的仪器上完成了大部分的核磁共振工作，其中一种——本提案的主题——已经过了它的鼎盛时期。该仪器用于常规核磁共振研究在一个步行模式。目前需要新的400核磁共振来取代老化和技术上有限的300核磁共振。与它所取代的300 NMR相比，它提供了更好的灵敏度，分辨率和性能。事实上，核磁共振性能足够好，我们期望在这个新的400核磁共振上做一些核磁共振，例如C和快速2D，而不是像我们目前那样在CIF更强大的13仪器上做。最后，主动屏蔽磁铁提供了一个更小的整体系统的足迹，并将允许我们更好地利用宝贵的实验室空间。请求的400 MHz核磁共振光谱仪为NIH资助的项目提供分析支持，这些项目发现新的合成策略，以高效和高纯度生产药理学上重要的药物材料。该仪器还支持美国国立卫生研究院资助的项目，这些项目发现新的天然产品，这些产品可能成为未来治疗一些世界上最严重疾病（包括结核病和麻风病）的特效药物。