400 MHz NMR Spectrometer for CSU Chemistry Facility

用于 CSU 化学设施的 400 MHz NMR 波谱仪

• 批准号: 7390018
• 负责人: Robert Michael Williams
• 金额: $ 25.08万
• 依托单位: COLORADO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7390018
• 关键词: 10 year old; Aging; Biological Factors; Chemistry; Colorado; Disease; Funding; Laboratories; Leprosy; Performance; Personal Satisfaction; Pharmaceutical Preparations; Resolution; System; Time; Tuberculosis; United States National Institutes of Health; Universities; Walking; Work; instrument; instrumentation

DESCRIPTION (provided by applicant): The Chemistry Department at Colorado State University is requesting funds to purchase a new 400 MHz NMR spectrometer that will replace our ten year old 300 NMR. The instrument will be managed within the Department's Central Instrumentation Facility (CIF). At the present time, we do the greatest portion of our NMR work on three heavily used instruments, one of which - the subject of this proposal - is well past its prime. This instrument is used for routine NMR studies in a walk-up mode. The new, 400 NMR is needed at this time to replace the aging and technically limited 300 NMR. It offers significantly better sensitivity, resolution and performance compared with the 300 NMR that it replaces. Indeed, the NMR performance is sufficiently good that we expect to do some kinds of NMR, e.g. C and fast 2D, on this new 400 NMR rather than on the more powerful 13 instruments in the CIF as we do at present. Finally, the actively shielded magnet provides for a much smaller overall system footprint and will allow us to make better use of valuable laboratory space. The 400 MHz NMR spectrometer requested provides analytical support to NIH funded projects that discover new synthetic strategies for producing pharmacologically important drug materials efficiently and in high purity. The instrument also supports NIH funded projects that discover new natural products that may be tomorrow's wonder drugs for some of the world's worst diseases including tuberculosis and leprosy.

描述（由申请人提供）：科罗拉多州立大学的化学系要求资金购买新的400 MHz NMR光谱仪，该光谱仪将取代我们10岁的300 NMR。该工具将在该部门的中央仪器设施（CIF）内进行管理。目前，我们在NMR工作中最大的一部分在三种大量使用的仪器上进行，其中之一 - 该提案的主题 - 远远超过了它的素数。该仪器用于步行模式下的常规NMR研究。目前需要新的400 NMR来替换老化和技术限制300 NMR。与替代的300 NMR相比，它具有明显更好的灵敏度，分辨率和性能。确实，NMR性能足够好，我们期望做某种NMR，例如C和Fast 2d，在这个新的400 NMR上，而不是像我们目前一样在CIF中更强大的13个乐器上。最后，积极的屏蔽磁铁提供了更小的整体占地面积，并使我们能够更好地利用有价值的实验室空间。所需的400 MHz NMR光谱仪为NIH资助的项目提供了分析支持，这些项目发现新的合成策略有效地生产了具有药理学重要的药物材料，并且具有高度纯度。该乐器还支持NIH资助的项目，这些项目发现新的天然产品可能是明天的神奇药物，包括世界上一些最严重的疾病，包括结核病和麻风病。