BICYCLOMYCIN SYNTHESIS AND ANTIBIOTIC BIOMECHANISM

双环霉素的合成和抗生素生物机制

• 批准号: 3128346
• 负责人: Robert Michael Williams
• 金额: $ 8.96万
• 依托单位: COLORADO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1982
• 资助国家: 美国
• 起止时间: 1982-05-01 至 1988-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3128346
• 关键词: antineoplastic antibiotics; drug design /synthesis /production; drug metabolism; saturated /unsaturated bonds

The objective of the proposed research is the total synthesis of the novel antibiotic bicyclomycin in optically active form and of select bicyclomycin analogs to be used in evaluating the chemical mechanism of antibacterial action of bicyclomycin. New synthetic methods for constructing the bicyclomycin ring system will be investigated. The synthetic strategem is of sufficient bravity and versatility to allow the elaboration of bicyclomycin and all synthetic analogs from a few common intermediates. By these methods, the chemical structural and dynamic properties of the bicyclomycin ring system as a "latent" Alpha,Beta-unsaturated pryuvamide (Michael acceptor) will be investigated.

拟议研究的目标是小说的全综合 光学活性形式的抗生素双环霉素和精选双环霉素 用于评估抗菌化学机制的类似物 双环霉素的作用。 构建新的合成方法 将研究双环霉素环系统。 综合策略是 具有足够的勇气和多功能性，可以详细阐述 双环霉素和一些常见中间体的所有合成类似物。 经过 这些方法，化学结构和动态性质 双环霉素环系统作为“潜在”α、β-不饱和丙酮酰胺 （迈克尔·阿克特）将受到调查。