Fruit Integrative Modelling (FRIM)

水果综合建模（FRIM）

• 批准号: BB/I004653/1
• 负责人: Lee Sweetlove
• 金额: $ 43.16万
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2010
• 资助国家: 英国
• 起止时间: 2010 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FI004653%2F1
• 关键词: Fruit; Integrative; Modelling; FRIM

Commercial fruit production is under significant pressure from environmental stresses, exacerbated by climate change, but also from changes in the consumer's demand for taste and nutritional value. One of the key goals of fruit biology is therefore to understand the factors that influence the contents of the ripe fruit that influence flavour and quality. Both genetic and environmental factors have a strong and multifaceted influence on fruit quality. They usually act and interact in such a complex way that it is extremely difficult to study their effects experimentally. It is possible to generate experimentally-derived models of fruit development in response to environmental conditions, but such models alone do not reveal how the genetic variation between different tomato cultivars, which acts on biochemical and cellular processes, affects the outcome. At a different level, it is also possible to make models of the metabolism inside the developing fruit which can predict how fast different components of the tomato are being made, but such models do not incorporate the cumulative effects of the environmental influences on the plant and fruit. The aim of this project is to combine these two modelling approaches so that it is possible to predict how the fruit of particular genetic variants will develop under a variety of environmental conditions, and in that way to select rationally tomato strains with desirable qualities.

商业水果生产受到环境压力的巨大压力，气候变化加剧了这种压力，而且消费者对口味和营养价值的需求也发生了变化。因此，水果生物学的关键目标之一是了解影响成熟水果风味和质量的因素。遗传和环境因素对果实品质有很强的多方面影响。它们通常以如此复杂的方式起作用和相互作用，以至于很难通过实验研究它们的影响。这是可能的，以实验为基础的水果发育模型，在环境条件下，但这样的模型本身并没有揭示不同的番茄品种之间的遗传变异，这对生物化学和细胞过程的作用，影响的结果。在不同的水平上，也可以制作发育中的果实内部的代谢模型，该模型可以预测番茄的不同成分的生成速度，但是这样的模型不包括环境对植物和果实的影响的累积效应。该项目的目的是将这两种建模方法联合收割机结合起来，以便能够预测特定遗传变异的果实在各种环境条件下将如何发育，并以这种方式合理选择具有理想品质的番茄品系。