Regulation of the plant metabolic network during stress

胁迫期间植物代谢网络的调节

• 批准号: BB/E024742/1
• 负责人: Lee Sweetlove
• 金额: $ 39.71万
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2007
• 资助国家: 英国
• 起止时间: 2007 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FE024742%2F1
• 关键词: Regulation; plant; metabolic; network; during

In the field, plants have to cope with environmental fluctuations which at their extremes cause stress to the plant. Under such stress conditions, the growth and development of the plant can be severely retarded. In an agricultural context, such sub-optimal growth conditions cause significant lowering of yields and are a major cause of variations in agricultural productivity from year to year. Furthermore, global climate changes are likely to dramatically exacerbate this problem. There is thus a pressing need to develop new varieties of staple crops that are more tolerant of abiotic stress conditions. Many modern crop species are the product of extensive breeding designed to maximise the biomass of the harvested organs. However, traits such as stress tolerance that are present in the wild progenitor species are often lost during the breeding process. Successful reintroduction of such traits will be dependent upon a detailed understanding of their molecular basis. One fo the key components of the response of plants to stress conditions is adaptive change in their metabolism. Understanding the nature of these metabolic reconfigurations is vital if we are to successfully generate new stress-resistant varieties of crops. Accordingly, the aim of the proposed work is to dissect the regulation of the metabolic network during oxidative stress in the model plant, Arabidopsis thaliana. Particular attention will be paid to discriminating between changes that occur at the level of gene expression and those that operate directly on proteins (so-called post-translational changes).

在田间，植物必须科普极端情况下对植物造成压力的环境波动。在这种胁迫条件下，植物的生长和发育可能严重受阻。在农业方面，这种次优的生长条件导致产量显著下降，是农业生产率逐年变化的主要原因。此外，全球气候变化可能会大大加剧这一问题。因此，迫切需要开发更能耐受非生物胁迫条件的主食作物新品种。许多现代农作物品种是广泛育种的产物，旨在最大限度地提高收获器官的生物量。然而，在野生祖先物种中存在的诸如胁迫耐受性的特征通常在育种过程中丢失。成功地重新引入这些性状将取决于对其分子基础的详细理解。植物对胁迫条件的反应的一个关键组成部分是其代谢的适应性变化。如果我们要成功培育新的抗逆作物品种，了解这些代谢重组的性质至关重要。因此，所提出的工作的目的是解剖的模式植物，拟南芥中的氧化应激过程中的代谢网络的调节。将特别注意区分发生在基因表达水平上的变化和直接作用于蛋白质的变化（所谓的翻译后变化）。

项目成果

Metabolic recovery of Arabidopsis thaliana roots following cessation of oxidative stress.

• DOI: 10.1007/s11306-011-0296-1
• 发表时间: 2012-02
• 期刊: METABOLOMICS
• 影响因子: 3.6
• 作者: Lehmann, Martin;Laxa, Miriam;Sweetlove, Lee J.;Fernie, Alisdair R.;Obata, Toshihiro
• 通讯作者: Obata, Toshihiro

Alteration of mitochondrial protein complexes in relation to metabolic regulation under short-term oxidative stress in Arabidopsis seedlings.

• DOI: 10.1016/j.phytochem.2010.11.003
• 发表时间: 2011-07
• 期刊: Phytochemistry
• 影响因子: 3.8
• 作者: Toshihiro Obata;A. Matthes;Susanne Koszior;M. Lehmann;W. Araújo;R. Bock;L. Sweetlove;A. Fernie

Role of Lon1 protease in post-germinative growth and maintenance of mitochondrial function in Arabidopsis thaliana.

• DOI: 10.1111/j.1469-8137.2008.02701.x
• 发表时间: 2009-02
• 期刊: The New phytologist
• 作者: Stamatis Rigas;G. Daras;Miriam Laxa;Nikolas Marathias;C. Fasseas;L. Sweetlove;P. Hatzopoulos