Understanding how the heart becomes more efficient

了解心脏如何变得更有效率

• 批准号: DP200103642
• 负责人: A/Prof Kelly Smith
• 金额: $ 33.01万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-05-05 至 2023-05-04
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP200103642
• 关键词: Understanding; how; heart; becomes; more

The body demands that the heart function at utmost efficiency. Trabeculae – folds within the heart lumen – maximise blood flow, contribute to chamber development and form the electrical conduction network of the heart. Problems with trabeculae formation cause cardiomyopathy and arrhythmia and yet we do not understand its basic development. The project will investigate the earliest stages of when this tissue develops its identity and examine the signalling, genetic, cellular and extracellular cues required to instruct trabeculae to form in the heart. Findings from this research will revise our understanding of when and how trabeculae form and provide key information about how to grow and repair this important tissue.

身体要求心脏以最高效率运转。小梁-在心腔内折叠-最大限度地增加血液流动，促进心腔发育并形成心脏的导电网络。小梁形成的问题会导致心肌病和心律失常，但我们对其基本发展尚不清楚。该项目将调查这种组织形成其身份的最早阶段，并检查指示小梁在心脏形成所需的信号、遗传、细胞和细胞外信号。这项研究的发现将修正我们对小梁形成时间和方式的理解，并为如何生长和修复这一重要组织提供关键信息。